BICYCLE THERAPEUTICS Ltd Contracts & Agreements

Service Agreement, dated March 18, 2024, by and between BicycleTx Ltd. and Michael Charles Ferguson Hannay (Filed With SEC on August 6, 2024)

Form of Securities Purchase Agreement (Filed With SEC on May 23, 2024)

Amendment No. 4 to Collaboration and License Agreement, dated January 17, 2024, between BicycleTx Limited and Ionis Pharmaceuticals, Inc (Filed With SEC on May 2, 2024)

Registration Rights Agreement, dated April 18, 2024, by and among the Company and 667, L.P. and Baker Brothers Life Sciences, L.P (Filed With SEC on April 18, 2024)

Consulting Agreement, dated April 17, 2024, by and between the Company and Veronica Jordan (Filed With SEC on April 18, 2024)

Non-Employee Director Compensation Policy, as amended as of December 13, 2023 (Filed With SEC on February 20, 2024)

Description of Securities (Filed With SEC on February 20, 2024)

Amendment No.1 to Service Agreement, dated July 24, 2023, by and between BicycleTx Limited and Kevin Lee (Filed With SEC on November 2, 2023)

Employment Agreement, dated June 22, 2023, by and between Bicycle Therapeutics Inc. and Alethia Young (Filed With SEC on August 3, 2023)

Description of Non-Voting Ordinary Shares (Filed With SEC on July 13, 2023)

Underwriting Agreement, dated July 12, 2023, by and among the Company, Goldman Sachs & Co. LLC, Jefferies LLC and SVB Securities LLC, as the Representatives of the several... (Filed With SEC on July 13, 2023)

Amendment No. 2 to Service Agreement, dated February 20, 2023, by and between BicycleTx Limited and Michael Skynner (Filed With SEC on May 4, 2023)

Amendment No. 1 to Amended and Restated Employment Agreement, dated March 29, 2023, by and between Bicycle Therapeutics Inc. and Lee Kalowski (Filed With SEC on May 4, 2023)

Amendment No. 1 to Amended and Restated Employment Agreement, dated February 20, 2023, by and between Bicycle Therapeutics Inc. and Nicholas Keen (Filed With SEC on May 4, 2023)

Amendment No. 1 to Service Agreement, dated February 20, 2023, by and between BicycleTx Limited and Nigel Crockett (Filed With SEC on May 4, 2023)

Amendment No. 1 to Service Agreement, dated February 20, 2023, by and between BicycleTx Limited and Alistair Milnes (Filed With SEC on May 4, 2023)

Employment Agreement, dated March 31, 2023, by and between Bicycle Therapeutics Inc. and Santiago Arroyo (Filed With SEC on May 4, 2023)

Amendment No. 1 to Service Agreement, dated February 27, 2023, by and between BicycleTx Limited and Dominic Smethurst (Filed With SEC on May 4, 2023)

Collaboration and Licence Agreement, dated March 27, 2023, by and between BicycleTx Limited and Novartis Pharma AG (Filed With SEC on May 4, 2023)

Third Amendment to the Discovery Collaboration and License Agreement, dated October 26, 2022, by and between Genentech, Inc. and BicycleTx Limited (Filed With SEC on February 28, 2023)

Non-employee Director Compensation Policy, as amended as of December 8, 2022 (Filed With SEC on February 28, 2023)

Amended and Restated Bicycle Therapeutics plc 2020 Equity Incentive Plan and forms of award thereunder (Filed With SEC on February 28, 2023)

Amendment No. 2 to Collaboration and License Agreement, dated August 1, 2022, between BicycleTx Limited and Ionis Pharmaceuticals, Inc (Filed With SEC on November 3, 2022)

Second Amendment to the Discovery Collaboration and License Agreement, dated June 27, 2022, by and between Genentech, Inc. and BicycleTx Limited (Filed With SEC on August 4, 2022)

First Amendment to the Discovery Collaboration and License Agreement, dated November 5, 2021, by and between Genentech, Inc. and BicycleTx Limited (Filed With SEC on August 4, 2022)

Second Amendment to Loan and Security Agreement, dated as of July 15, 2022, by and among Bicycle Therapeutics plc and each of its Subsidiaries, the Lenders and Hercules Capital,... (Filed With SEC on July 15, 2022)

Amendment No. 1 to Collaboration and License Agreement, dated December 17, 2021, between BicycleTx Limited and Ionis Pharmaceuticals, Inc (Filed With SEC on March 1, 2022)

Non-employee Director Compensation Policy, amended as of December 14, 2021 (Filed With SEC on March 1, 2022)

Service Agreement, dated January 5, 2022, by and between BicycleTx Ltd. and Alistair Milnes (Filed With SEC on March 1, 2022)

Amendment to Amended and Restated Employment Agreement, dated January 6, 2022, by and between BicycleTx Ltd. and Michael Skynner, Ph.D (Filed With SEC on March 1, 2022)

Share Purchase Agreement, dated as of July 9, 2021, between Bicycle Therapeutics plc and Ionis Pharmaceuticals, Inc (Filed With SEC on November 4, 2021)

Collaboration and License Agreement, dated as of July 9, 2021, between BicycleTx Limited and Ionis Pharmaceuticals, Inc (Filed With SEC on November 4, 2021)

Underwriting Agreement, dated October 12, 2021, by and among the Company, Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC and SVB Leerink LLC, as the Representatives of the... (Filed With SEC on October 14, 2021)

Amendment to Letter Agreement, dated May 24, 2021, between Bicycle Therapeutics plc and Citibank, N.A (Filed With SEC on August 5, 2021)

Settlement Agreement, dated November 20, 2020, by and among Bicycle Therapeutics plc, Bicycle Therapeutics Inc., BicycleRD Limited, BicycleTx Limited and Pepscan Systems BV,... (Filed With SEC on March 11, 2021)

First Amendment to Loan and Security Agreement, dated March 10, 2021, by and among Bicycle Therapeutics plc, BicycleTx Limited, BicycleRD Limited and Bicycle Therapeutics, Inc.,... (Filed With SEC on March 11, 2021)

Form of letter agreement to amend Service Agreement by and between the BicycleTx Ltd. and its executive officers in the United Kingdom, effective January 1, 2021 (Filed With SEC on March 11, 2021)

Settlement and Licence Agreement, dated November 20, 2020, by and among Bicycle Therapeutics plc, Bicycle Therapeutics Inc., BicycleRD Limited, BicycleTx Limited and Pepscan... (Filed With SEC on March 11, 2021)

Non-employee Director Compensation Policy, amended as of December 16, 2020 (Filed With SEC on March 11, 2021)

Service Agreement, dated July 9, 2020, by and between BicycleTx Ltd. and Dominic Smethurst, MA, MBChB, MRCP, MFPM (Filed With SEC on March 11, 2021)

Amendment to Letter Agreement, dated October 27, 2020, between Bicycle Therapeutics plc and Citibank, N.A (Filed With SEC on March 11, 2021)

Letter Agreement, dated July 1, 2020, by and between Bicycle Therapeutics plc and Citibank, N.A (Filed With SEC on November 5, 2020)

Loan and Security Agreement, dated September 30, 2020, by and among Bicycle Therapeutics plc, BicycleTx Limited and BicycleRD Limited, the lenders party thereto, and Hercules... (Filed With SEC on October 1, 2020)

Bicycle Therapeutics plc 2020 Equity Incentive Plan and forms of award thereunder (Filed With SEC on August 5, 2020)

Form of letter agreement to amend Service Agreement by and between the BicycleTx Ltd. and its executive officers in the United Kingdom, effective January 1, 2020 (Filed With SEC on May 7, 2020)

Forms of award agreements under the Bicycle Therapeutics Share Option Plan, as amended (Filed With SEC on March 10, 2020)

Description of Securities (Filed With SEC on March 10, 2020)

Amended and Restated Employment Agreement, dated September 26, 2019, by and between BicycleTx Ltd. and Michael Skynner, Ph.D (Filed With SEC on March 10, 2020)

Amended and Restated Employment Agreement, dated September 26, 2019, by and between Bicycle Therapeutics Inc. and Nicholas Keen, Ph.D (Filed With SEC on March 10, 2020)

Service Agreement, dated September 26, 2019, by and between BicycleTx Ltd and Nigel Crockett (Filed With SEC on March 10, 2020)

Non-employee Director Compensation Policy (Filed With SEC on March 10, 2020)

Form of Indemnity Deed between the Company and its executive officers (Filed With SEC on November 12, 2019)

Form of Indemnity Deed between the Company and its directors (Filed With SEC on November 12, 2019)

Rules of the Bicycle Therapeutics Share Option Plan, as amended on September 12, 2019 (Filed With SEC on November 7, 2019)

Amended and Restated Employment Agreement, dated September 26, 2019, by and between Bicycle Therapeutics Inc. and Lee Kalowski (Filed With SEC on September 30, 2019)

Service Agreement, dated September 26, 2019, by and between BicycleTx Ltd. and Kevin Lee (Filed With SEC on September 30, 2019)

Employment Agreement between the registrant and Kevin Lee, Ph.D., MBA, to be in effect upon the closing of this offering (Filed With SEC on May 15, 2019)

Employment Agreement between the registrant and Lee Kalowski, MBA, to be in effect upon the closing of this offering (Filed With SEC on May 15, 2019)

Employment Agreement between the registrant and Michael Skynner, Ph.D., to be in effect upon the closing of this offering (Filed With SEC on May 15, 2019)

Employment Agreement between the registrant and Nicholas Keen, Ph.D., to be in effect upon the closing of this offering (Filed With SEC on May 15, 2019)

Employment Agreement between the registrant and Peter Leone, MBA, dated January 28, 2019 (Filed With SEC on May 15, 2019)

Contract for the Sale of Leasehold Land with Vacant Possession, by and between Convergence Pharmaceuticals Limited and BicycleRD Limited, dated October 31, 2017, which is pursuant... (Filed With SEC on May 13, 2019)

Senior Executive Cash Incentive Bonus Plan (Filed With SEC on May 13, 2019)

2019 Employee Share Purchase Plan (Filed With SEC on May 13, 2019)

2019 Share Option Plan and forms of award agreements thereunder (to be adopted prior to the effectiveness of this registration statement) (Filed With SEC on May 13, 2019)

Form of Deed of Indemnity between the registrant and each of its directors and executive officers (Filed With SEC on May 13, 2019)

Form of Underwriting Agreement (Filed With SEC on May 13, 2019)

Form of Deposit Agreement (Filed With SEC on May 13, 2019)

Registration Rights Agreement by and among Bicycle Therapeutics Limited and the Investors listed therein, dated December 21, 2018 (Filed With SEC on April 26, 2019)

Form of Share Option Contract of Bicycle Therapeutics Limited for employees in England (Filed With SEC on April 26, 2019)

Form of Share Option Contract of Bicycle Therapeutics Limited for employees in the United States (Filed With SEC on April 26, 2019)

Clinical Trial and License Agreement, by and between Bicycle Therapeutics Limited, Cancer Research Technology Limited, and Cancer Research UK, dated December 13, 2016, as amended... (Filed With SEC on April 26, 2019)

Lease Agreement, by and between Bicycle Therapeutics Inc. and King 4 Hartwell Place, LLC, dated September 26, 2017 (Filed With SEC on April 26, 2019)

Contract for the Sale of Leasehold Land with Vacant Possession, by and between Convergence Pharmaceuticals Limited and BicycleRD Limited, dated October 31, 2017, which is pursuant... (Filed With SEC on April 26, 2019)

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BICYCLE THERAPEUTICS Ltd Contracts & Agreements