Amendment No. 2 to Registration Rights Agreement, dated May 3, 2023, between the Registrant and the Investors

THIS AMENDMENT No. 2 to the Registration Rights Agreement (this “Amendment”) is made as of May 3, 2023, by and among BeiGene, Ltd., a Cayman Islands exempted company (the “Company”) and the undersigned Investors. Capitalized terms used but not otherwise defined herein shall have the meanings given to such terms in the Registration Rights Agreement dated as of November 16, 2016, by and among the Company and the Investors thereto (the “Registration Rights Agreement”).

WHEREAS, the Company and the Investors are parties to the Registration Rights Agreement;

WHEREAS, in accordance with Section 3.2 of the Registration Rights Agreement, no amendment, alteration or modification of any of the provisions of the Registration Rights Agreement shall be binding unless made in writing and signed by each of the Company and the Investors; and

WHEREAS, the Company and the Investors desire to amend the Registration Rights Agreement, effective as of the date first written above, as set forth in this Amendment.

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the Investors hereby agree as follows:

1.Section 2.9 of the Registration Rights Agreement is deleted in its entirety and replaced with:

“Termination of Status as Registrable Securities. The Registrable Securities shall cease to be Registrable Securities upon the earliest to occur of the following events: (i) such Registrable Securities have been sold pursuant to an effective Registration Statement; (ii) such Registrable Securities have been sold by the Investors pursuant to Rule 144 (or other similar rule), (iii) such Registrable Securities may be resold by the Investor holding such Registrable Securities without limitations as to volume or manner of sale pursuant to Rule 144; or (iv) December 31, 2026.”

IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first written above.

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first written above.

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first written above.