FIRST AMENDMENT TO THENON-EMPLOYEE DIRECTOR COMPENSATION PLAN OF BAXALTA INCORPORATED

Exhibit 10.1

FIRST AMENDMENT TO

THE NON-EMPLOYEE DIRECTOR COMPENSATION PLAN

OF BAXALTA INCORPORATED

The Non-Employee Director Compensation Plan (the “Plan”), as adopted effective July 1, 2015, by the Board of Directors (the “Board”) of Baxalta Incorporated (“Baxalta”), is hereby amended as follows, pursuant to the authority retained by the Board under Section 8.1 of the Plan.

RECITALS:

A. The Plan was adopted by the Board effective July 1, 2015, to provide for payment of compensation to members of the Board who are not employees of Baxalta or its subsidiaries for their services as members of the Board and its committees (“Participants”).

B. The Plan provides for an automatic grant of stock options (“Options”) and restricted stock units (“Restricted Stock Units”) to each Participant, with such grants to occur on the date of each annual meeting of Baxalta’s shareholders (an “Annual Meeting”).

C. The Plan also provides that all grants of Options and Restricted Stock Units will vest and, in the case of Options, become exercisable, on the date of, and immediately prior to, the next Annual Meeting after the date of grant.

D. On January 11, 2016, Baxalta entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Shire plc and BearTracks, Inc., a wholly-owned subsidiary of Shire plc, pursuant to which Baxalta will merge with BearTracks, Inc., and become a wholly owned subsidiary of Shire plc (the “Merger”).

E. As a result of the Merger, Baxalta will not hold an Annual Meeting in 2016. Prior to announcement of the Merger, Baxalta’s 2016 Annual Meeting was scheduled to be held on May 10, 2016.

F. The Board has determined that it is appropriate to amend the Plan as set forth herein in order to reflect the effect of the Merger, and the cancellation of the 2016 Annual Meeting, on the Plan and awards previously granted under the Plan.

THEREFORE, the Plan is hereby amended as follows:

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