Sixth Amendment to Credit and Guaranty Agreement, by and among Athenex, Inc., the Lenders party thereto, and Oaktree Fund Administration, LLC, as administrative agent for the Lenders, dated as of August 14, 2022

Exhibit 10.2

SIXTH AMENDMENT TO CREDIT AND GUARANTY AGREEMENT

THIS SIXTH AMENDMENT TO CREDIT AND GUARANTY AGREEMENT (this “Amendment”), dated as of August 14, 2022, is made by and among ATHENEX, INC., a Delaware corporation (as applicable, the “Borrower”), the Lenders party hereto and OAKTREE FUND ADMINISTRATION, LLC, as administrative agent for the Lenders (in such capacity, the “Administrative Agent”).

WHEREAS, the parties hereto are party to that certain Credit and Guaranty Agreement, dated as of June 19, 2020 (as amended by that certain First Amendment and Limited Waiver to Credit and Guaranty Agreement, dated as of June 3, 2021, that certain Second Amendment to Credit and Guaranty Agreement, dated December 14, 2021, that certain Third Amendment to Credit and Guaranty Agreement and First Amendment to Warrants, dated as of January 19, 2022, that certain Fourth Amendment to Credit and Guaranty Agreement, Second Amendment to the Warrants and Partial Release of Collateral, dated as of June 21, 2022, that certain Fifth Amendment to Credit and Guaranty Agreement, dated as of June 29, 2022, and as further amended, restated or modified from time to time, the “Credit Agreement”) by and among the Borrower, the Guarantors party thereto from time to time, the Lenders party thereto from time to time, and the Administrative Agent;

WHEREAS, Section 3.03(b)(iv)(B) of the Credit Agreement requires that the Borrower make a mandatory prepayment in the principal amount equal to $7,500,000, plus accrued and unpaid interest in respect of the principal amount being prepaid, the Exit Fee in respect of the principal amount being prepaid and the Prepayment Fee in respect of the principal amount being prepaid (the “Specified Prepayment”) under certain circumstances; and

WHEREAS, the Borrower has requested that the Lenders and the Administrative Agent agree to (i) make certain amendments to the Credit Agreement and (ii) waive the requirement to make the Specified Prepayment, in each case, subject to the terms and conditions contained herein.

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows.

SECTION 1 Capitalized Terms. All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise defined herein shall have the meanings assigned to them in the Credit Agreement.

SECTION 2 Amendment to the Credit Agreement. Notwithstanding anything in the Credit Agreement or the other Loan Documents to the contrary, the Lenders and the Borrower hereby agree that on the Sixth Amendment Effective Date, Section 3.03(b)(iv)(B) is hereby amended and restated in its entirety to read as follows:

“(B) On or prior to September 30, 2022, the Borrower shall make a mandatory prepayment in a principal amount equal to the amount by which $6,875,000 exceeds any prepayments made by the Borrower on or prior to such date pursuant to Section 3.03(b)(i) from the Net Cash Proceeds from the sale of the China API business to TiHe Capital (Beijing) Co., Ltd. in accordance with the Equity Purchase Agreement, dated as of July 7, 2022 (the “China API Sale”), plus accrued and unpaid interest in respect of the principal amount being repaid, the Exit Fee in respect of the principal amount being repaid and the Prepayment Fee in respect of the principal amount being repaid. The principal amount of such prepayment shall reduce dollar-for-dollar the amount of any mandatory prepayment that would be required pursuant to Section 3.03(b)(i) from the Net Cash Proceeds of the China API Sale after September 30, 2022. By way of example, if the Borrower consummates the China API Sale prior to September 30, 2022 and makes a mandatory prepayment of the Loans pursuant to Section 3.03(b)(i) on or prior to such date in excess of $6,875,000, then no further mandatory prepayment shall be required pursuant to this Section 3.03(b)(iv)(B).”

SECTION 3 Limited Waiver. Subject to the satisfaction of the conditions precedent specified in Section 4 hereof, the Administrative Agent and the Lenders hereby waive any Default or Event of Default under Section 11.01(a) and Section 11.01(b) of the Credit Agreement arising out of the failure to make the Specified Prepayment (the “Payment Defaults”) and any Default or Event of Default under Section 11.01(d) of the Credit Agreement arising out of the failure to provide timely notice of the Payment Defaults pursuant to Section 8.02(a) of the Credit Agreement (together with the Payment Defaults, the “Specified Defaults”). For the avoidance of doubt, the Borrower shall be

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required to make the mandatory prepayment required pursuant to Section 3.03(b)(iv)(B) of the Credit Agreement as amended by this Amendment on the date set forth therein.

SECTION 4 Effectiveness. Sections 2 and 3 to this Amendment shall become effective only upon the satisfaction or waiver by the Lenders of the following conditions precedent (the date of such satisfaction or waiver of the following conditions being referred herein as the “Sixth Amendment Effective Date”):

(a) Each of the Borrower and the Lenders shall have executed this Amendment and the Administrative Agent shall have received a fully executed copy of this Amendment.

(b) The representations and warranties of the Borrower set out in Section 5 below shall be true and correct on and as of the Sixth Amendment Effective Date, except for any representation or warranty expressly stated to be made as of a specific date, in which case such representation or warranty shall be true and correct as of such specific date.

SECTION 5 Representations and Warranties.

The Borrower represents and warrants as of the date hereof and on the Sixth Amendment Effective Date that:

(a) Power and Authority. The Borrower has full power, authority and legal right to enter into and perform its obligations under this Amendment and the other Loan Documents to which it is a party.

(b) Authorization; Enforceability. The execution of this Amendment and performance hereunder are within the Borrower’s corporate or other organizational powers and have been duly authorized by all necessary corporate or other organizational action including, if required, approval by all necessary holders of Equity Interests. This Amendment has been duly executed and delivered by the Borrower and constitutes a legal, valid and binding obligation of the Borrower, enforceable against the Borrower in accordance with its terms, except as such enforceability may be limited by (i) bankruptcy, insolvency, reorganization, moratorium or similar laws of general applicability affecting the enforcement of creditors’ rights and (ii) the application of general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law).

(c) Governmental and Other Approvals; No Conflicts. None of the execution, delivery and performance by the Borrower of the Amendment (i) requires any Governmental Approval of, registration or filing with, or any other action by, any Governmental Authority or any other Person, except for such as have been obtained or made and are in full force and effect, (ii) will violate (1) any Law, (2) any Organic Document of the Borrower or (3) any order of any Governmental Authority, that in the case of clause (ii)(1) or clause (ii)(3), individually or in the aggregate, could reasonably be expected to result in a Material Adverse Effect, (iii) will violate or result in a default under any Material Agreement binding upon the Borrower that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Effect or (iv) will result in the creation or imposition of any Lien (other than Permitted Liens) on any asset of any Obligor or any of its Subsidiaries.

(d) No Default or Event of Default. No event has occurred and is continuing or would result after giving effect to this Amendment that would constitute an Event of Default or a Default (other than the Specified Defaults).

SECTION 6 Miscellaneous.

(a) References Within Loan Documents. Each reference in the Credit Agreement on and after the Sixth Amendment Effective Date to “this Agreement” and the words “hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a reference to the Credit Agreement as amended by Section 2 of this Amendment,.

(b) Binding Effect. This Amendment binds and is for the benefit of the successors and permitted assigns of each party.

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(c) Limited Waiver. Except as specifically modified above, (i) the Credit Agreement and all other Loan Documents shall remain in full force and effect, and are hereby ratified and confirmed and (ii) the execution, delivery and effectiveness of this Amendment shall not operate as a waiver of any right, power or remedy of the Administrative Agent or the Lenders nor constitute a waiver of any provision of the Credit Agreement or any of the Loan Documents. None of the Administrative Agent or any Lender is under any obligation to enter into this Amendment. The entering into this Amendment by such parties shall not be deemed to limit or hinder any rights of any such party under the Loan Documents, nor, except as provided in Section 2, as applicable, shall it be deemed to create or infer a course of dealing between any such party, on the one hand, and the Borrower, on the other hand, with regard to any provision of the Loan Documents.

(d) Governing Law. THIS AMENDMENT SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF NEW YORK.

(e) Severability of Provisions. Each provision of this Amendment is severable from every other provision in determining the enforceability of any provision.

(f) Counterparts. This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment. Delivery of an executed counterpart of a signature page of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission will be as effective as delivery of a manually executed counterpart hereof.

(g) Loan Documents. This Amendment and the documents related thereto shall constitute Loan Documents.

(h) Electronic Execution of Certain Other Documents. The words “execution,” “execute”, “signed,” “signature,” and words of like import in or related to any document to be signed in connection with this Amendment and the transactions contemplated hereby (including without limitation assignments, assumptions, amendments, waivers and consents) shall be deemed to include electronic signatures, the electronic matching of assignment terms and contract formations on electronic platforms approved by the Administrative Agent, or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other similar state laws based on the Uniform Electronic Transactions Act.

[Balance of Page Intentionally Left Blank; Signature Pages Follow]

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IN WITNESS WHEREOF, the parties hereto have duly executed this Amendment, as of the date first above written.

BORROWER AND ISSUER: