Amendment No. 10 to Commercial Manufacturing Services Agreement between Atara Biotherapeutics, Inc. and Charles River Laboratories, Inc. dated May 31, 2024

AMENDMENT NO. 10 TO COMMERCIAL MANUFACTURING SERVICES AGREEMENT

This Amendment No. 10 to the Commercial Manufacturing Services Agreement (“Tenth Amendment”) is made, entered into and effective as of May 31, 2024 (the “Tenth Amendment Effective Date”) by and between ATARA BIOTHERAPEUTICS, INC., a Delaware corporation with offices at 2380 Conejo Spectrum Street, Suite 200, Thousand Oaks, CA 91320 (“Atara”); and CHARLES RIVER LABORATORIES, INC. (successor in interest to COGNATE BIOSERVICES INC.), a Delaware corporation with offices at 4600 East Shelby Drive, Suite 108, Memphis, TN 38118 (“Manufacturer”). Each of Atara and Manufacturer are referred to in this Tenth Amendment as a “Party” and together, the “Parties.” All capitalized terms used, but not otherwise defined herein, shall have the same meaning ascribed to them in the Commercial Services Agreement (as defined below).

BACKGROUND

WHEREAS, the Parties have entered into that certain Commercial Manufacturing Services Agreement, effective as of January 1, 2020 (as previously amended by that certain First Amendment, dated as of September 1, 2021; by that certain Second Amendment, dated as of May 25, 2022; by that certain Third Amendment, dated as of July 1, 2022 (the “Third Amendment”); by that certain Fourth Amendment, dated as of January 30, 2023; by that certain Fifth Amendment, dated as of September 27, 2023; by that certain Sixth Amendment, dated as of December 30, 2023; by that certain Seventh Amendment, dated as of January 31, 2024; by that certain Eighth Amendment, dated as of March 31, 2024 (the “Eighth Amendment”); and by that certain Ninth Amendment, dated as of April 30, 2024 (the “Ninth Amendment”), collectively, the “Commercial Services Agreement”), pursuant to which Atara engaged Manufacturer to perform certain commercial manufacturing services in relation to Atara’s products, as further described in individual work orders entered into thereunder;

WHEREAS, the Parties desire to amend the Commercial Services Agreement and certain Work Orders thereto as set forth in this Tenth Amendment; and

WHEREAS, Section 15.7 of the Commercial Services Agreement provides that the Commercial Services Agreement may only be modified by a writing signed by authorized representatives of each Party.

NOW, THEREFORE, the Parties desire, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, to amend the Commercial Services Agreement as set forth in this Tenth Amendment as of the Tenth Amendment Effective Date.

“14.1 Term. This Agreement will take effect as of the Effective Date and, unless earlier terminated pursuant to this Article 14, will expire on August 31, 2024 (the “Final Date” and such period between February 1, 2023 and the Final Date, the “Remaining Period”). Notwithstanding the termination or expiration of this Agreement, the terms and conditions of this Agreement shall continue to apply to any active or in progress Work Orders (including Delivery of the final Remaining Batches and any PBMC Batches ordered during the Remaining Period) until each such Work Order has been completed, expired or otherwise terminated in accordance with the terms herein or therein.”

“(iii) as of May 31, 2024, Sections 2 and 3 of Schedule 1 to Work Order 1 under this Agreement, as amended by the Third Amendment, are hereby deleted in their entirety and replaced by Exhibit C to the Tenth Amendment, dated May 31, 2024.”

“The parties agree to negotiate in good faith a new commercial manufacturing agreement by [[***]] and if the parties are unable to finalize such new agreement prior to [[***]], the parties shall mutually agree upon an extension of the Remaining Period, which will include payment of applicable Suite Fees and new Batch commitments to ensure continuity of supply of Product until such new agreement is executed.”

[SIGNATURE PAGE TO FOLLOW]

IN WITNESS WHEREOF, the undersigned have executed this Tenth Amendment as of the Tenth Amendment Effective Date.

EXHIBIT A

UPDATED PRODUCTION FORECAST STARTS

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EXHIBIT B

SUITE FEES

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EXHIBIT C

SECTIONS 2 AND 3 OF SCHEDULE 1 TO WORK ORDER 1

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