ARDELYX, INC. | Business Contracts

First Amendment to the Manufacturing Services Agreement dated February 27, 2023, between Ardelyx, Inc. and Patheon Pharmaceuticals Inc (Filed With SEC on March 2, 2023)

Second Amendment to the Loan and Security Agreement dated February 9, 2023, by and between Ardelyx, Inc. and SLR Investment Corp (Filed With SEC on March 2, 2023)

Amendment Number 1 to License Agreement, dated as of November 27, 2017, by and among Ardelyx, Inc., and Kyowa Kirin Co., Ltd (Filed With SEC on March 2, 2023)

Fourth Amendment to Lease, dated May 25, 2021, by and between Ardelyx, Inc. and 34175 Ardenwood Venture, LLC (Filed With SEC on March 2, 2023)

Second Amended and Restated Non-Employee Director Compensation Program (Filed With SEC on August 4, 2022)

First Amendment to the Loan and Security Agreement dated August 1, 2022, by and between Ardelyx, Inc. and SLR Investment Corp (Filed With SEC on August 4, 2022)

Royalty and Sales Milestone Interest Acquisition Agreement (Filed With SEC on August 4, 2022)

Form of Executive Retention Agreement Version 2 (Filed With SEC on February 28, 2022)

Retention Agreement, dated October 25, 2021, by and between Ardelyx, Inc. and Mike Raab (Filed With SEC on February 28, 2022)

Retention Agreement, dated October 25, 2021 (Filed With SEC on February 28, 2022)

Retention Agreement, dated October 25, 2021, by and between Ardelyx, Inc. and Justin Renz (Filed With SEC on February 28, 2022)

Amendment Number One to Second Amended (Filed With SEC on February 28, 2022)

Form of Executive Retention Agreement Version 1 (Filed With SEC on February 28, 2022)

Open Market Sales Agreement dated August 13, 2021, by and between Ardelyx, Inc. and Jefferies LLC (Filed With SEC on August 17, 2021)

Fourth Amendment to the Loan and Security Agreement, dated as of July 29, 2021, by and among Ardelyx, Inc., Solar Capital Ltd. and the lenders party thereto (Filed With SEC on July 30, 2021)

Fifth Amendment to Lease, dated May 25, 2021, by and between Ardelyx, Inc. and 34175 Ardenwood Venture, LLC (Filed With SEC on June 1, 2021)

Third Amendment to the Loan and Security Agreement, dated May (Filed With SEC on May 6, 2021)

Description of the Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 8, 2021)

First Amendment to Loan and Security Agreement, dated as of October 9, 2020, by and among Ardelyx, Inc., Solar Capital Ltd. and the lenders party (Filed With SEC on October 14, 2020)

Change in Control Severance Agreement, dated June 2, 2020, by and between Ardelyx, Inc. and Susan Rodriquez (Filed With SEC on August 6, 2020)

Manufacturing Services Agreement, dated May 18, 2020, between Ardelyx, Inc., and Patheon Pharmaceuticals Inc (Filed With SEC on August 6, 2020)

Change in Control Severance Agreement, dated June 8, 2020, by and between Ardelyx, Inc. and Justin Renz (Filed With SEC on August 6, 2020)

Offer Letter, dated June 2, 2020, by and between Ardelyx, Inc. and Justin Renz (Filed With SEC on August 6, 2020)

Offer Letter, dated April 27, 2020, by and between Ardelyx, Inc. and Susan Rodriguez (Filed With SEC on August 6, 2020)

Transition and Separation Agreement dated November 25, 2019, by and between the Company and Mark Kaufmann (Filed With SEC on March 6, 2020)

Description of the Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 6, 2020)

Underwriting Agreement, dated as of December 4, 2019, among Ardelyx, Inc., Citigroup Global Markets Inc., Cowen and Company LLC, SVB Leerink LLC, and Piper Jaffray & Co., as... (Filed With SEC on December 5, 2019)

Amended and Restated Non-Employee Director Compensation Program (Filed With SEC on May 7, 2019)

Sales Agreement, dated as of August 9, 2018, between Ardelyx, Inc. and Leerink Partners LLC (Filed With SEC on August 10, 2018)

Loan and Security Agreement, dated May 16, 2018, by and between the Company and Solar Capital Ltd. and Western Alliance Bank (Filed With SEC on August 7, 2018)

Exit Fee Agreement, dated May 16, 2018, by and between the Company and Solar Capital Ltd. and Western Alliance Bank (Filed With SEC on August 7, 2018)

Transition and Separation Agreement dated July 8, 2018, by and between the Company and Reginald Seeto, MBBS (Filed With SEC on August 7, 2018)

Underwriting Agreement, dated as of May 22, 2018, among Ardelyx, Inc. and Jefferies LLC and Leerink Partners LLC, as representatives of the underwriters named therein (Filed With SEC on May 29, 2018)

Second Amended and Restated Change in Control and Severance Agreement by and between Ardelyx, Inc. and Elizabeth Grammer (Filed With SEC on May 8, 2018)

Second Amended and Restated Change in Control and Severance Agreement by and between Ardelyx, Inc. and David P. Rosenbaum, Ph.D (Filed With SEC on May 8, 2018)

License Agreement, dated November 27, 2017, by and between Kyowa Hakko Kirin Co., Ltd. and Ardelyx, Inc (Filed With SEC on March 14, 2018)

License Agreement, dated December 11, 2017, by and between Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. and Ardelyx, Inc (Filed With SEC on March 14, 2018)

Transition and Separation Agreement dated August 21, 2017, by and between the Company and Dr. Paul Korner (Filed With SEC on November 7, 2017)

ARDELYX, INC. CHANGEIN CONTROL SEVERANCE AGREEMENT (Filed With SEC on February 17, 2017)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on August 8, 2016)

THIRD AMENDMENT TO LEASE (Filed With SEC on August 8, 2016)

ARDELYX, INC. SECURITIES PURCHASE AGREEMENT (Filed With SEC on August 8, 2016)

AMENDMENT NUMBER ONE TO TERMINATION AGREEMENT AND TO MANUFACTURING AND SUPPLY AGREEMENT (Filed With SEC on March 4, 2016)

Ardelyx, Inc. 7,500,000 Shares Common Stock ($0.0001 parvalue) Underwriting Agreement (Filed With SEC on January 13, 2016)

ARDELYX, INC. SECURITIES PURCHASE AGREEMENT (Filed With SEC on August 12, 2015)

TERMINATION AGREEMENT (Filed With SEC on August 12, 2015)

ARDELYX, INC. CHANGE IN CONTROL SEVERANCE AGREEMENT (Filed With SEC on March 5, 2015)

TRANSITION AND SEPARATION AGREEMENT (Filed With SEC on September 9, 2014)

SECOND AMENDMENT TO LEASE (Filed With SEC on September 9, 2014)

Additional abbreviations may also be used though not in the above list. (Filed With SEC on June 18, 2014)

ARDELYX, INC. 2014EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE, SCOPE AND ADMINISTRATION OF THE PLAN (Filed With SEC on June 9, 2014)

Ardelyx, Inc. Shares Common Stock ($0.0001 parvalue) Underwriting Agreement (Filed With SEC on June 9, 2014)

ARDELYX, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM (Filed With SEC on June 9, 2014)

ARDELYX, INC. 2014EQUITY INCENTIVE AWARD PLAN ARTICLE 1. PURPOSE (Filed With SEC on June 9, 2014)

ARDELYX, INC. AMENDEDAND RESTATED CHANGE IN CONTROL SEVERANCE AGREEMENT (Filed With SEC on June 9, 2014)

[Page 1 of 2] (Filed With SEC on June 9, 2014)

ARDELYX, INC. 2014EQUITY INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE (Filed With SEC on June 9, 2014)

ARDELYX, INC. 2014EQUITY INCENTIVE AWARD PLAN RESTRICTED STOCK UNIT AWARD GRANT NOTICE (Filed With SEC on June 9, 2014)

ARDELYX, INC. INDEMNIFICATION AGREEMENT (Filed With SEC on June 9, 2014)

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on June 9, 2014)

[Page 1 of 2] (Filed With SEC on June 9, 2014)

ARDELYX, INC. CHANGEIN CONTROL SEVERANCE AGREEMENT (Filed With SEC on June 9, 2014)

LICENSE OPTION AND LICENSE AGREEMENT BY AND BETWEEN SANOFI AND ARDELYX,INC. DATED FEBRUARY 21, 2014 EXHIBITS (Filed With SEC on June 5, 2014)

AMENDMENT NUMBER ONE TO LICENSE AGREEMENT BY AND BETWEEN ASTRAZENECA AB AND ARDELYX, INC. DECEMBER 23, 2013 Page 1 of 9 Pages AMENDMENT NUMBER ONE TO LICENSE AGREEMENT (Filed With SEC on June 5, 2014)

LICENSE AGREEMENT BY AND BETWEEN ASTRAZENECA AB AND ARDELYX, INC. OCTOBER 4, 2012 CONTENTS (Filed With SEC on June 5, 2014)

LICENSE AGREEMENT BY AND BETWEEN ASTRAZENECA AB AND ARDELYX, INC. OCTOBER 4, 2012 CONTENTS (Filed With SEC on May 19, 2014)

AMENDMENT NUMBER ONE TO LICENSE AGREEMENT BY AND BETWEEN ASTRAZENECA AB AND ARDELYX, INC. DECEMBER 23, 2013 Page 1 of 9 Pages AMENDMENT NUMBER ONE TO LICENSE AGREEMENT (Filed With SEC on May 19, 2014)

LICENSE OPTION AND LICENSE AGREEMENT BY AND BETWEEN SANOFI AND ARDELYX,INC. DATED FEBRUARY 21, 2014 EXHIBITS (Filed With SEC on May 19, 2014)

ARDELYX, INC. AMENDEDAND RESTATED INVESTORS RIGHTS AGREEMENT Dated as of June 23, 2011 TABLE OF CONTENTS (Filed With SEC on May 19, 2014)

LEASE by and between 34175 ARDENWOOD VENTURE, LLC, aDelaware limited liability company and NTERYX, INC., a Delawarecorporation LEASE (Filed With SEC on May 19, 2014)

FIRST AMENDMENT TO LEASE (Filed With SEC on May 19, 2014)

ARDELYX, INC. 2008STOCK INCENTIVE PLAN (Filed With SEC on May 19, 2014)

ARDELYX, INC. 2008 STOCK INCENTIVE PLAN NOTICE OF STOCK OPTION AWARD (Filed With SEC on May 19, 2014)

ARDELYX, INC. 2008 STOCK INCENTIVE PLAN NOTICE OF RESTRICTED STOCK PURCHASE AWARD (Filed With SEC on May 19, 2014)

ARDELYX, INC. (84)