Amendment No. 1 to the Cell Line License Agreement by and between WuXi Biologics Ireland Limited and Oruka Therapeutics, Inc., dated November 20, 2024

Exhibit 10.33

[***] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.

AMENDMENT NO. 1 TO THE CELL LICENSE AGREEMENT

THIS AMENDMENT NO. 1 TO THE CELL LINE LICENSE AGREEMENT (“Amendment”), effective as of November 20, 2024 (the “Amendment Effective Date”), is entered into and made by and between WuXi Biologics Ireland Limited, (“WuXi Biologics”), and Oruka Therapeutics, Inc. (“Licensee”). WuXi Biologics and Licensee may be referred to herein individually as a “Party” and collectively as the “Parties.”

WHEREAS, WuXi Biologics (and Licensee have entered into that certain Cell Line License Agreement, dated as of March 4, 2024, (the “License Agreement”); and

WHEREAS, the Parties now desire to amend the License Agreement;

NOW, THEREFORE, in consideration of the foregoing, of the mutual promises set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto, intending legally to be bound, hereby agree as follows:

Notwithstanding the foregoing, in lieu of Licensee paying WuXi Biologics the Royalty provided for in Section 5.1, Licensee, or its sublicensee or assignee may, at any time, in its sole discretion, pay to WuXi Biologics, on a Drug Product-by-Drug Product basis, a fixed non-creditable, non-refundable royalty buyout payment as set forth below (a “Royalty Buyout Payment”). Once WuXi Biologics has received the Royalty Buyout Payment from Licensee, or its sublicensee or assignee, all future royalty obligations with respect to such Drug Product will be extinguished and Licensee will no longer owe any Royalty with respect to such Drug Product. Upon the applicable Royalty Buyout Payment being fully paid with respect to a Drug Product, the rights and licenses granted with respect to such Drug Product under this Agreement (including for clarity in Section 2.1) shall become fully paid-up, royalty free, perpetual and irrevocable.

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IN WITNESS WHEREOF, the Parties hereto have caused this Amendment to be duly executed as of the Amendment Effective Date set forth above.