Resignation Letter from Directors to Applied Molecular Evolution, Inc. CEO

Summary

Stanley T. Crooke, Peter K. Hilal, and Clive Meanwell have resigned as directors of Applied Molecular Evolution, Inc. due to serious concerns about the company's senior management and recent board actions. Their letter to CEO William D. Huse explains that their resignations are a result of these issues and expresses hope that the new board will address them.

EX-4.1 3 a84554exv4w1.txt EXHIBIT 4.1 EXHIBIT 4.1 September 13th, 2002 William D. Huse MD PhD Chief Executive Officer Applied Molecular Evolution, Inc 3520 Dunhill St San Diego, Ca 92121 Dear Bill, Given the events of today, we believe it important to make clear that our resignations as Directors arose from our serious concerns about how senior management was running the company. These concerns were exacerbated by the events of the last several days, including the manner in which a Director was added to the board. We hope, and trust, that these issues will be addressed by the new Board. Sincerely, /s/ STANLEY T. CROOKE /s/ PETER K. HILAL /s/ CLIVE MEANWELL Stanley T. Crooke, M.D. Ph.D. Peter K. Hilal, M.D. Clive Meanwell, M.D.