Share Purchase Agreement by and between Amphastar Pharmaceuticals, Inc., Nanjing Zhongpan Enterprise Management Consulting Center (LLP), Nanjing Zhanrun Enterprise Management Consulting Center (LLP), and Listening Dragon Investment Company Limited, dated May 6, 2021

Amphastar Pharmaceuticals，Inc., is a company established and existing in accordance with the laws of the State of Delaware, the United States of America (“Party A” or “AMPH”), which is the majority shareholder of Amphastar Nanjing Pharmaceuticals, Inc. (“ANP”);

Nanjing Zhongpan Enterprise Management Consulting Center (LLP), a limited liability partnership established and existing in accordance with the laws of the PRC, with unified social credit code [***************] (“Party B1” or “ZP”);

Nanjing Zhanrun Enterprise Management Consulting Center (LLP), a limited liability partnership established and existing in accordance with the laws of the PRC, with unified social credit code [***************]. (“Party B2” or “ZR”); and

Listening Dragon Investment Company Limited, a limited liability company established and existing in accordance with the laws of Hong Kong (“Party B3” or “LD”).

Amphastar Pharmaceuticals，Inc.，一家依据美国特拉华州法律设立并有效存续的公司（“甲方”或“AMPH”），该公司是美药星（南京）制药有限公司（“美药星”）的主要股东；

南京众盼企业管理咨询中心（有限合伙），一家依据中华人民共和国法律设立并有效存续的有限合伙企业，统一社会信用代码为[*****************]（“乙方1”或“众盼”）；

南京沾润企业管理咨询中心（有限合伙），一家依据中华人民共和国法律设立并有效存续的有限合伙企业，统一社会信用代码为[*****************]。（“乙方2”或“沾润”）；及

Listening Dragon Investment Company Limited，一家依据香港法律设立并有效存续的有限责任公司。（“乙方3”或“听龙”）

As of the date hereof (the “Execution Date”), the capitalization structure of ANP is as follows:

On May 4, 2021, the board of directors of ANP adopted resolutions to approve the Transaction (as defined below), and all shareholders of ANP waived any right of first refusal with respect to the Transaction.

截至本协议签署之日（“签署日”），美药星的股权结构如下所示：

2021年5月4日，美药星董事会通过了批准本次交易（定义见下文）的决议，美药星的所有股东同意放弃就本次交易享有的优先购买权。

The Transaction

本次交易

Consideration of the Transaction

According to the Appraisal Report, the appraised value of the equity interest of ANP corresponding to US$1 registered capital previously invested in ANP is US$1.583. The appraised value of the Target Equity based upon registered capital of B1, B2, and B3 respectively and the appraised value of an equity interest in ANP is as follows:

The Parties agree that the purchase price for the Target Equity (the “Purchase Price”) will be the appraised value of the Target Equity as set forth above.

Within five (5) days after the Closing Date, Party A shall pay Party B1 and Party B2 their respective Purchase Price to their Asset Sale Accounts (as defined below), and pay Party B3 its Purchase Price to the offshore bank account designated by Party B3. Each of Party B1, Party B2 and Party B3

本次交易的交易价款

根据资产评估报告，美药星此前投资的每1美元注册资本对应的股权评估价值为美元。基于乙方1、乙方2和乙方3各自的注册资本评估的标的股权的评估价值及美药星每一股权的评估价值如下所示：

各方同意，标的股权的转让价款（“转让价款”）为上述标的股权的评估价值。

甲方应于交割日后5日内向乙方1和乙方2各自的资产变现账户（定义见下文）支付乙方1和乙方2各自的转让价款，并向乙方3指定的境外银行账户支付乙方3的转让价款。乙方1、乙方2和乙方3均应在交割日前5个工作日内将银行账户信息书面通知甲方。

The Closing of the Transaction

The obligations of Party A to consummate the Transaction are subject to the fulfillment, or waiver by Party A, of the following conditions:

The boards of directors of ANP and AMPH shall have approved the Transaction;

All shareholders of ANP shall have waived any right of first refusal with respect to the Transaction;

The articles of association shall have been amended and duly adopted and executed by the board of directors of ANP;

The amendment registration with local branch of state administration for market regulation with respect to the Transaction (the “SAMR Registration”) has been completed;

The reporting to local branch of ministry of commerce with respect to the Transaction has been completed (if necessary);

The filing with local branch of state administration of foreign exchange (or its designated commercial banks) with respect to the Transaction has been completed; and

The asset sale accounts (the “Asset Sale Accounts”) of ZR and ZP have been set up.

The Parties agree that the date on which the conditions in Section 3.1 are completed or waived by Party A will be the closing date of the Transaction (the “Closing Date”). Party A will become the owner of the Target Equity as of the Closing Date and will enjoy and assume all the rights and obligations as a shareholder of ANP with respect to the Target Equity.

The Parties agree that all the profit and loss of the Target Equity, including but not limited to the profit and loss arising from operations, incurred during the period from the benchmark date of the appraisal report (i.e., December 31, 2020) to the Closing Date will be owned by Party B1, B2, and B3 respectively. The term “profit and loss” refers to the ownership interest in the financial statements during such period as confirmed by the Parties.

Each Party will bear their respective taxes arising out of or in connection with the execution and performance of this Agreement (including, without limitation, the enterprise income tax, individual income tax and stamp duty) in accordance with relevant laws and regulations of the PRC.

本次交易的交割

甲方履行本次交易的义务以下列条件得到满足或被甲方豁免为前提：

各方同意，第3.1条约定的条件得到满足之日或被甲方豁免之日为本次交易的交割日(“交割日”)。甲方将于交割日成为标的股权的所有人，并就标的股权享有和承担作为美药星股东的所有权利和义务。

各方同意，标的股权自资产评估报告基准日（即2020年12月31日）至交割日期间发生的全部损益，包括但不限于经营产生的损益，分别由乙方1、乙方2和乙方3所有。“损益”系指经各方确认的该期间财务报表中的所有者权益。

各方将根据相关中国法律法规承担各自因签署和履行本协议而产生的或与之相关的税收（包括但不限于企业所得税、个人所得税和印花税）。

Representations and Warranties of Party A

Party A is an enterprise legal person legally registered and validly existing in accordance with the laws of the State of Delaware, the United States of America and with the legal right to perform its obligations hereunder, and has obtained all authorizations or approvals necessary for the execution of this Agreement.

Execution and performance of this Agreement by Party A will neither violate relevant laws, regulations, or the articles of incorporation of Party A, nor contravene any agreements entered into by Party A previously, or any statements, representations, undertakings, or warranties made by Party A in favor of any third party.

甲方的陈述与保证

甲方为根据美国特拉华州法律合法设立并有效存续的企业法人，具有履行本协议项下义务的合法权利，并已获得签署本协议所需的一切授权或批准。

甲方签署和履行本协议不会违反有关法律法规以及甲方的公司章程，也不存在与甲方此前已签订的协议或已经向任何第三方作出的任何陈述、声明、承诺或保证相冲突之情形。

Representations and Warranties of Party B

Each of Party B1 and Party B2 is an enterprise legal person legally registered and validly existing in accordance with the laws of the PRC and to perform its obligations hereunder, and has obtained all authorizations or approvals necessary for the execution of this Agreement.

Party B3 is an enterprise legal person legally registered and validly existing in accordance with the laws of Hong Kong and to perform its obligations hereunder, and has obtained all authorizations or approvals necessary for the execution of this Agreement.

Execution and performance of this Agreement by each of Party B1, Party B2 and Party B3 will neither violate relevant laws, regulations, or the constitutional documents of either Party B1, Party B2 or Party B3, respectively, nor contravene any agreements entered into by each of Party B1, Party B2 and Party B3 previously, or any statements, representations,

Each of Party B1, Party B2 and Party B3 possess valid title to all its Target Equity and have the full and valid right to sell and transfer the Target Equity to Party A, free and clear from all liens, mortgagees, pledges, claims, or any third party’s interests.

乙方的陈述与保证

乙方1和乙方2均为依据中国法律合法设立并有效存续的企业法人，具有履行本协议项下义务的合法主体资格，并已获得签署本协议所需的一切授权或批准。

乙方3为根据香港法律合法设立并有效存续的企业法人，具有履行本协议项下义务的合法主体资格，并已取得执行本协议所需的一切授权或批准。

乙方1、乙方2和乙方3分别签署及履行本协议，不会违反有关法律、法规或乙方1、乙方2或乙方3的宪章性文件，也不存在与乙方1、乙方2和乙方3此前已签订的任何协议或乙方1、乙方2和乙方3各做作出的有利于任何第三方的任何陈述、声明、承诺或保证相冲突之情形。

乙方1、乙方2和乙方3各自拥有其全部标的股权的有效的所有权，并拥有向甲方出售和转让标的股权的完全和有效的权利，不受任何留置权、抵押权、质押权、请求权或任何第三方权利的影响。

Unless expressly stated otherwise in this Agreement, any notice or other communication (a “Notice”) sent by one Party to any of the other Parties in connection with this Agreement must be delivered by an internationally recognized courier, prepaid registered airmail, or other form of recorded delivery to the address set out in Section 6. The addresses of the Parties are as follows:

If to Party A:

If to Party B1:

If to Party B2:

If to Party B3:

除本协议另有明确规定外，一方向任一其他方发出的、与本协议相关的任何通知或其他通信（“通知”）必须以国际公认的快递、邮资付讫航空挂号信或其他有记录的交付形式交付至本第6条所列明的地址。各方通讯地址如下：

给甲方

给乙方1

给乙方2

给乙方3

Assignment

权利义务的转让

Entire Agreement

全部协议

Confidentiality

Unless otherwise required by PRC Laws, US Laws and Hong Kong Laws, no Party may disclose this Agreement or the transactions, arrangements or any other matters agreed upon or referred to in this Agreement, or disclose the information of the other Parties, without the prior written consent of the other Parties, which consent will not be unreasonably withheld or delayed. The provisions of this Section will not apply to the information which has entered into the public domain (unless the information enters into the public domain due to a Party’s breach of the confidentiality obligations under this Section).

Notwithstanding the provisions of Section 9.1, any Party may disclose this Agreement or the transactions, arrangements or any other matters agreed upon or referred to in this Agreement to its shareholders, employees, directors or professional advisors to the extent that such disclosure is reasonably required for the purposes of this Agreement; provided that that Party shall ensure that the relevant shareholders, employees, directors or

保密

除非中国法律、美国法律和香港法律另有规定，未经其他方事先书面同意（该同意不会被不当拒绝或延迟），任何一方不得披露本协议或本协议中约定或提及的交易、安排、任何其他事项或其他各方信息。本节的规定不适用于已进入公共领域的信息（除非该信息是由于一方违反本节规定的保密义务而进入公共领域）。

尽管有第9.1条的规定，任何一方均可向其股东、雇员、董事或专业顾问披露本协议或本协议中约定或提及的交易、安排或任何其他事项，并应以为本协议目的的合理要求为限；但该方应确保相关股东、雇员、董事或专业顾问了解并遵守本协议中提及的保密义务。如果法律或法院判决或其他适用的有管辖权的证券交易所要求任何一方披露本协议和本协议中约定或提及的交易、安排或任何其他事项，该方仅可以披露法律要求披露的部分，但必须先将该等披露的形式和条款通知其他方，且其他方有合理的机会就此发表意见；且该方必须采取一切措施，以便在适用法律和法规允许的范围内对该等相关信息进行保密处理。

Force Majeure

An event of force majeure referred to in this Agreement shall mean any unforeseen, unavoidable and insurmountable events which are beyond the control of a Party to this Agreement, and which arise after the Effective Date and as a result of which any Party is unable to perform its obligations under this Agreement. Such events shall include in particular earthquakes, typhoons, flood, fire, other acts of nature, epidemic, war, riots, hostility, public disturbance, acts of public enemies, prohibitions or acts of any governmental authority or public agency (“Force Majeure Event”).

The Party which claims to be affected by a Force Majeure Event shall promptly inform the other Parties in writing of said Force Majeure Event. The Party claiming that the Force Majeure Event makes its performance of this Agreement objectively impossible or impractical must use its best reasonable endeavors to resolve or mitigate the consequences of said Force Majeure Event.

Failure of any Party to perform its obligations under this Agreement in whole or in part, as a result of a Force Majeure Event as described in Section 10.1 shall not constitute a breach of this Agreement, and the performance of such obligations will suspend during the Force Majeure Event until resolved. The Parties shall immediately resume performance of their respective obligations under this Agreement upon resolution of the Force Majeure Event. Where the Force Majeure Event or its impact lasts for 60 days or more, any Party may terminate this Agreement by sending notice of such termination to the other Parties in writing.

不可抗力

本协议所称不可抗力事件是指在生效日之后发生的且导致任一方无法履行其在本协议项下的义务的、超出本协议一方控制范围的任何不可预见、不可避免且不可克服的事件。此类事件尤其应包括地震、台风、洪水、火灾、其他自然灾害、流行病、战争、暴动、敌意、公众骚乱、公敌行动、任何政府机关或公共机构的禁令或行为（“不可抗力事件”）。

主张受到不可抗力事件影响的一方应立即通过书面形式将该等不可抗力事件通知其他方。主张不可抗力事件导致其对本协议的履行在客观上成为不可能或不实际的一方，应尽最大合理努力消除或减轻此等不可抗力事件的影响。

第10.1条所述的不可抗力事件导致一方未能全部或部分履行其在本协议项下的义务不应构成对本协议的违约，该等义务的履行将在不可抗力事件期间中止，直至得到解决。不可抗力事件解决后，各方应立即恢复履行各自在本协议项下的义务。如果不可抗力事件或其影响持续六十（60）日或以上，任何一方均可向其他方发出书面通知终止本协议。

Liabilities for Breach

Where any Party violates its representations, warranties, obligations or responsibilities under this Agreement or otherwise breaches this Agreement (“Breaching Party”), the Breaching Party shall be liable for its breach of this Agreement. This Agreement shall not restrict, and is not intended to limit, a Party’s right to seek damages including economic losses, reasonable costs and fees incurred as a result of such breach including, but not limited to, reasonable attorneys’ fees, notarial fees, travel expenses, execution fees, appraisal fees, and arbitration fees.

If Party A fails to pay the Purchase Price to either Party B1, B2, or B3 respectively within the period of time specified in this Agreement, and Party B1, B2, or B3, as the case may be, has fulfilled all obligations under this Agreement and neither that Party, nor any entity acting on its behalf or for its benefit, nor the actions of any sovereign, is the cause of the delay in payment, then Party A shall pay Party B1, Party B2 and Party B3 liquidated damages in the amounts of 0.1% of their respective Purchase Price for each day of delay, but not to exceed 3% of their respective Purchase Price.

No failure of any Party to exercise, and no delay by it in exercising, any right, power or remedy in connection with this Agreement (each a “Right”) shall operate as a waiver thereof, nor shall any single or partial exercise of any Right preclude any other or further exercise of such Right or exercise of any other Right. The Rights provided in this Agreement are cumulative and not exclusive of any other Rights (whether provided by law or otherwise). Any express waiver of any breach of this Agreement shall not be deemed to be a waiver of any subsequent breach.

违约责任

任何一方违反其在本协议项下的陈述、保证、义务或责任或以其他方式违反本协议（“违约方”），则违约方应就其在本协议项下的违约承担违约责任。本协议不应限制，或旨在限制一方寻求因该等违约要求损害赔偿的权利，包括经济损失、因违约而产生的合理费用和开支，包括但不限于合理的律师费、公证费、差旅费、执行费、鉴定费和仲裁费等。

如甲方未能在本协议约定的期限内分别向乙方1、乙方2和乙方3支付转让价款，且乙方1、乙方2和乙方3（就其分别适用的情形而定）已履行了本协议项下的所有义务，且该方或代表为其利益所行事的任何实体或任何政府行为均非导致延迟支付的原因，则每延迟1日，甲方应当向乙方1、乙方2和乙方3按各自转让价款的0.1%支付违约金，但该等违约金总额说不应超过其各自转让价款的3%。

任何一方未行使或延迟行使与本协议有关的任何权利、权力或救济（“权利”），均不得视为对该权利的放弃，行使任何单一或部分权利，也不得妨碍任何其他或进一步行使该权利或行使其他任何权利。本协议规定的权利是累积的，不排除任何其他权利（不论是法律或其他规定）。对本协议的任何违约的任何明确放弃不应被视为对任何随后违约的放弃。

Effectiveness and Termination of the Agreement

This Agreement may be terminated upon unanimous agreement by the Parties through consultations. Such consultation must be requested by a Party in writing.

This Agreement may be terminated pursuant to Section 10.3 above.

协议的生效和终止

本协议可在各方通过协商一致后终止。该等协商须由一方以书面形式提出。

本协议可根据上述第10.3条终止。

Severability

可分割性

Applicable Law and Dispute Resolution

The formation, performance, validity and interpretation of, and resolution of disputes under this Agreement shall be governed by PRC laws.

In the event of any dispute arising out of the interpretation and performance of this Agreement, the Parties shall resolve such dispute through friendly consultations requested in writing. If any dispute is not resolved by friendly consultations within 30 days after the date such consultations were first requested in writing by a Party, either Party may submit the relevant dispute to the Shanghai International Arbitration Center (“SHIAC”) and resolved in accordance with the arbitration rules of SHIAC in force at the time of applying for arbitration. The place of arbitration shall be Shanghai, and the language used in arbitration shall be Chinese and English. The arbitration award shall be final and binding on the Parties.

适用法律及争议解决

本协议的订立、履行、效力、解释和争议的解决均受中国法律管辖。

如因本协议的解释和履行而产生任何争议，各方应通过书面请求进行友好协商解决。如果任何争议在一方首次以书面形式请求友好协商之日起30天内未能解决，任何一方均可将有关争议提交上海国际仲裁中心(“上海仲裁中心”)，并按照申请仲裁时有效的上海仲裁中心的仲裁规则解决。仲裁地点为上海仲裁语言为中文和英文。仲裁裁决为最终裁决，对各方具有约束力。

Short Form Equity Transfer Agreement

简版股权转让协议

Language

语言

Counterparts

副本