Amendment No. 6 to Contract Award issued by the Biomedical Advanced Research and Development Authority of the United States Department of Health and Human Services, dated December 23, 2020

Exhibit 10.22

CERTAIN INFORMATION IDENTIFIED BY BRACKETED ASTERISKS ([* * *]) HAS BEEN OMITTED FROM THIS EXHIBIT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

11.THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

☐ The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers                                                   ☐is extended,         ☐is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended , by one of the following methods: (a) By completing Items 8 and 15, and returning    copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted ; or (c) By separate letter or electronic communication which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted , such change may be made by letter or electronic communication, provided each letter or electronic communication makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12.ACCOUNTING AND APPROPRIATION DATA (If required)

See Schedule

13.THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

E. IMPORTANT:Contractor            ☐is not       ☒is required to sign this document and return1copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

Tax ID Number:20 ###-###-#### DUNS Number:082804936

The purpose of this modification is to:

1)Extend the period of performance end date of CLIN0001 without additional cost to the government from 12/31/2020 to 6/30/2021. 2)Revise Article B.2. Estimated Cost and Fixed Fee and Article B.5. Advance Understandings; 3)Revise Section F - Deliveries or Performance; Article F.2. Deliverables; 4)Revise Section G - Contract Administration Data; Article G.1. Replace Contracting Officer; Add Contract Specialist Article G.3. Key Personnel Article G.5. Invoice/Financing Request and Contract Financial Reporting

Continued ...

Except as provided herein, all terms and conditions of the document referenced in Item 9 A or 10A, as heretofore changed, remains unchanged and in full force and effect.

NAME OF OFFEROR OR CONTRACTOR

ALTIMMUNE, INC. 1305044

Beginning with the effective date of this modification, the Government and the Contractor mutually agree to the following:

ARTICLE B.2. ESTIMATED COST AND FIXED FEE – paragraph d. is revised as follows:

d. It is estimated that the amount currently allotted will cover performance of the contract through June 30, 2021.

ARTICLE B.5. ADVANCE UNDERSTANDINGS – paragraph c. is here by deleted in its entirety and replaced as follows:

c. Subcontracts

Prior written consent from the Contracting Officer in the form of Contracting Officer Authorization (COA) is required for any subcontract that:

•Is Fixed-Price and exceeds $[***]or [***]% of the total estimated cost of the Contract, whichever value is greater.

The Contracting Officer shall request appropriate supporting documentation in order to review and determine authorization, pursuant with FAR Clause 52.244-2, Subcontracts. After receiving written consent of the subcontract by the Contracting Officer, the Contractor shall provide a copy of the signed, executed subcontract and consulting agreement to the Contracting Officer within ten (10) calendar days.

Note: Consulting services are treated as subcontracts and subject to the ‘consent to subcontract’ provisions set forth in this Section.

SECTION F – DELIVERIES OR PERFORMANCE

ARTICLE F.2. DELIVERABLES – is hereby revised as follows:

ATTN: Kathleen Sears (Contracting Officer)

U.S. Department of Health & Human Services

Office of the Assistant Secretary for Preparedness and Response Biomedical Advanced Research & Development Authority

200 C Street, S.W. Washington, DC 20515

Email: ***@***

ATTN: Janet Alvanzo (Contract Specialist)

U.S. Department of Health & Human Services

Office of the Assistant Secretary for Preparedness and Response Biomedical Advanced Research & Development Authority

200 C Street, S.W. Washington, DC 20515

Email: ***@***

SECTION G - CONTRACT ADMINISTRATION DATA

ARTICLE G.1. CONTRACTING OFFICER - is hereby modified as follows:

The following Contracting Officer (CO) will represent the USG for the purpose of this contract:

Kathleen Sears (Contracting Officer) HHS/ASPR/BARDA

200 C Street, S.W. Washington, D.C. 20515

(202) 205-4521

Email: ***@***

Add Janet Alvanzo as Contract Specialist

Janet Alvanzo (Contract Specialist) HHS/ASPR/BARDA

200 C Street, S.W. Washington, D.C. 20515

(202) 205-5185

Email: ***@***

1)The Contracting Officer is the only individual who can legally commit the Government to the expenditure of public funds. No person other than the Contracting Officer can make any changes to the terms, conditions, general provisions, or other stipulations of this contract.

2)The Contracting Officer is the only person with the authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; change the delivery schedule; (4) authorize reimburse to the Contractor of any costs incurred during the performance of this contract; (5) otherwise change any terms and conditions of this contract.

ARTICLE G.3. KEY PERSONNEL – is hereby modified as follows:

Pursuant to the Key Personnel clause incorporated in Section I of this contract, the following individuals are considered to be essential to the work being performed hereunder:

The key personnel specified in this contract are considered to be essential to work performance. At least thirty (30) business days prior to diverting any of the specified individuals to other programs or contracts, including, where practicable, an instance when an individual must be replaced as a result of leaving the employ of the Contractor, the Contractor shall notify the Contracting Officer and shall submit comprehensive justification for the diversion or replacement request (including proposed substitutions for key personnel) to permit evaluation by the Government of the impact on performance under this contract. The Contractor shall not divert or otherwise replace any key personnel without the written consent of the Contracting Officer.

ARTICEL G.5. INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORTING – table, is hereby

deleted and replaced as follows:

Include Program Support Center (PSC) in Receipt of Invoices:

Documents shall be delivered electronically to the Contracting Officer (CO), the Contracting Specialist (CS), the Contracting Officer’s Representative (COR) and PSC. Unless otherwise specified by the Contracting Officer all deliverables and reports furnished to the Government under the resultant contract (including invoices) shall be addressed as follows:

End of Modification P00006

All other terms and conditions of the contract remain in full force and effect.