Therapeutic Cooling or Induced Hypothermia

EX-4.3 6 a19030orexv4w3.txt EXHIBIT 4.3 Exhibit 4.3 AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT THIS AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this "Amendment"), entered into on April 13, 2006, among ALSIUS CORPORATION, a California corporation (the "Company"), and the undersigned investors in the Company (the "Investors"). RECITALS: A. Certain of the Investors hold shares of the Company's Common Stock, Series A, Series B, Series C-D, Series E and/or Series F Preferred Stock and possess registration rights, information rights, rights of first refusal, and other rights pursuant to that certain Tenth Amended and Restated Investor Rights Agreement, dated as of September 2, 2004, among the Company, such Investors and certain other shareholders of the Company (the "Tenth Restated Agreement"). B. On or about the date hereof, in connection with a bridge financing (the "Bridge Financing"), the Company is issuing a series of 8% Unsecured Convertible Promissory Notes (the "Bridge Notes") and warrants to purchase Common Stock of the Company (the "Warrants"). C. It is a condition to the closing of the Bridge Financing that this Amendment be executed by the parties hereto, and the parties are willing to execute, and to be bound by the provisions of, this Amendment. D. The undersigned Investors desire to amend the definition of "Registrable Securities" under Section 1.1 of the Tenth Restated Agreement to include the shares of stock issuable upon conversion of the Bridge Notes and exercise of the Warrants. E. The undersigned Investors desire to amend Section 1.2(a) of the Tenth Restated Agreement to amend the date upon which a demand registration may be requested. F. The Investors executing this Amendment hold a majority of the shares held by all Investors who are a party to the Tenth Restated Agreement and a majority of the shares of Series C-D, Series E and Series F Preferred Stock or Common Stock issuable upon conversion thereof, and therefore, have the power under Section 3.6 of the Tenth Restated Agreement to amend such agreement. NOW, THEREFORE, in consideration of the mutual promises and covenants set forth herein, the parties to the Tenth Restated Agreement hereby agree that the Tenth Restated Agreement shall be amended as follows: 1. Added Definition of 2006 Bridge Notes in Section 1.1. The undersigned Investors hereby agree that a new definition shall be added to Section 1.1 of the Tenth Restated Agreement to read as follows: "2006 Bridge Notes" means the convertible promissory notes made by the Company, dated April 13, 2006, in connection with a bridge financing of the Company of approximately $6,000,000." 2. Revised Definition of "Warrants." The undersigned Investors hereby agree that the definition of "Warrants" in Section 1.1 of the Tenth Restated Agreement shall be deleted in its entirety and replaced with the following: ""Warrants" means those certain warrants to purchase Common Stock of the Company (i) dated April 30, 2003, issued to the initial purchasers of the Bridge Notes and (ii) dated April 13, 2006, issued to the initial purchasers of the 2006 Bridge Notes." 3. Revised Definition of "Registrable Securities." The undersigned Investors hereby agree that the definition of "Registrable Securities" in Section 1.1 of the Tenth Restated Agreement shall be deleted in its entirety and replaced with the following: ""Registrable Securities" means (i) the Common Stock issued in exchange for the common stock issued by Retroperfusion Systems, Inc. ("RSI") upon conversion of the RSI Series B, Series C and Series D Preferred Stock and in exchange for the RSI Series E and Series F Preferred Stock, (ii) the Common Stock issued upon exercise of the warrants issued under the Loan and Warrant Subscription Agreements dated on or about August 17, 1993, (iii) the Common Stock issued under the Loan and Warrant Subscription Agreements dated October 1994, (iv) the Common Stock issued or issuable upon conversion of the Series A, Series B, Series C-D, Series E and Series F Preferred Stock, (v) the Common Stock issuable upon exercise of the Warrants issued in connection with the Bridge Notes, (vi) the Common Stock issued or issuable upon conversion of the 2006 Bridge Notes, (vii) the Common Stock issuable upon exercise of the Warrants issued in connection with the 2006 Bridge Notes and (viii) any Common Stock of the Company issued or issuable in respect of the above described securities upon any stock split, stock dividend, recapitalization, or similar event, or any Common Stock otherwise issued or issuable with respect to the above described securities; provided, however, that shares of Common Stock or other securities shall not be treated as Registrable Securities for purposes of Section 1 hereof if they have been sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction." 2. Revised Section 1.2(a). The undersigned Investors hereby agree that the lead-in sentence of Section 1.2(a) of the Tenth Restated Agreement shall be deleted in its entirety and replaced with the following: "(a) In case the Company shall receive at any time after the earlier of (i) June 30, 2007 and (ii) six (6) months after the effective date of the first registration statement filed by the Company covering an offering of any of its securities to the public, a written request from Holders ("Initiating Holders") that the Company effect any registration, qualification or compliance with respect to at -2- least forty percent (40%) of the Registrable Securities (or any lesser number of Registrable Securities if the anticipated aggregate offering price to the public from the proposed sale of such Registrable Securities, net of underwriting discounts and commissions, would exceed $8,000,000), the Company will:" 3. Remainder of Tenth Restated Agreement Unchanged. Except as amended by this Amendment, the Tenth Restated Agreement shall otherwise remain in full force and effect. 4. Governing Law. This Amendment shall be governed by and construed under the laws of the State of California, without regard to its conflicts of laws provisions. 5. Counterparts. This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 6. Facsimile Signatures. This Amendment may be executed and delivered by facsimile and upon such delivery, the facsimile signature will be deemed to have the same effect as if the original signature had been delivered to the other parties. The original signature copy shall be delivered to the other parties by mail. The failure to deliver the original signature copy and/or the non-receipt of the original signature copy shall have no effect upon the binding and enforceable nature of this Amendment. IN WITNESS WHEREOF, the undersigned Investors and the Company have executed this Amendment as of the day and year first above written. ALSIUS CORPORATION, a California corporation By /s/ William J. Worthen ------------------------------------- William J. Worthen President and Chief Executive Officer Address: 15770 Laguna Canyon Road Suite 150 Irvine, CA ###-###-#### -3- MAYFIELD VIII By: /s/ Kevin Fong ------------------------------- Name: Kevin Fong Title: Managing Director Address: 2800 Sand Hill Road Menlo Park, CA 94025 MAYFIELD ASSOCIATES FUND III By: /s/ Kevin Fong ------------------------------- Name: Kevin Fong Title: Managing Director Address: 2800 Sand Hill Road Menlo Park, CA 94025 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -4- FEVER TRUST By: /s/ James Beck ------------------------------- Name: James Beck Title: Administrative Trustee Address: 2800 Sand Hill Road Menlo Park, CA 94025 FEVER TRUST II By: /s/ James Beck ------------------------------- Name: James Beck Title: Administrative Trustee Address: 2800 Sand Hill Road Menlo Park, CA 94025 FEVER TRUST III By: /s/ James Beck ------------------------------- Name: James Beck Title: Administrative Trustee Address: 2800 Sand Hill Road Menlo Park, CA 94025 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -5- HUTTON LIVING TRUST By /s/ Wende Hutton --------------------------- Name: Wende S. Hutton Title: Trustee Address: 2 Santiago Avenue Atherton, CA 94027 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -6- NEW ENTERPRISE ASSOCIATES VII, L.P. By: NEA Partners VII, Limited Partnership Its General Partner By: /s/ Eugene A. Treinor III ------------------------------------ Name: Eugene A. Treinor III Title: Attorney-in-fact Address: 2800 Sand Hill Road Menlo Park, CA 94025 NEA PRESIDENTS FUND, L.P. By: NEA General Partners, L.P. Its General Partner By: /s/ Eugene A. Treinor III ------------------------------------ Name: Eugene A. Treinor III Title: Attorney-in-fact Address: 2800 Sand Hill Road Menlo Park, CA 94025 NEA VENTURES 1997, LIMITED PARTNERSHIP By: /s/ Louis B. Van Dyck ------------------------------------- Name: Louis B. Van Dyck Title: General Partner Address: 2800 Sand Hill Road Menlo Park, CA 94025 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -7- SIGHTLINE HEALTHCARE FUND II, L.P. By: /s/ Arch C. Smith ------------------------------------- Name: Arch C. Smith Title: Managing Director Address: 50 South Sixth Street, Suite 1390 Minneapolis, MN 55402 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -8- VERTICAL FUND I, L.P. By Vertical Group, L.P., General Partner By: x /s/ Stephen D. Baksa ------------------------------------- Name: Stephen D. Baksa Title: General Partner Address: 25 DeForest Avenue Summit, NJ 07901 VERTICAL FUND II, L.P. By Vertical Group, L.P., General Partner By: x /s/ Stephen D. Baksa ------------------------------------- Name: Stephen D. Baksa Title: General Partner Address: 25 DeForest Avenue Summit, NJ 07901 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -9- MPM BIOVENTURES II, L.P. By: MPM Asset Management II, L.P., its General Partner By: MPM Asset Management II LLC, its General Partner By: /s/ Kurt C. Wheeler ----------------------------------- Name: Kurt C. Wheeler Title: Investment Manager Address: 111 Huntington Avenue 31st Floor Boston, MA 02199 MPM BIOVENTURES II-QP, L.P. By: MPM Asset Management II, L.P., its General Partner By: MPM Asset Management II LLC, its General Partner By: /s/ Kurt C. Wheeler ----------------------------------- Name: Kurt C. Wheeler Title: Investment Manager Address: 111 Huntington Avenue 31st Floor Boston, MA 02199 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -10- MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG By: MPM Asset Management II, L.P., in its capacity as the Special Limited Partner By: MPM Asset Management II LLC, its General Partner By: /s/ Kurt C. Wheeler ----------------------------------- Name: Kurt C. Wheeler Title: Investment Manager Address: 111 Huntington Avenue 31st Floor Boston, MA 02199 MPM ASSET MANAGEMENT INVESTORS 2000 B LLC By: /s/ Kurt C. Wheeler ----------------------------------- Name: Kurt C. Wheeler Title: Investment Manager Address: 111 Huntington Avenue 31st Floor Boston, MA 02199 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -11- CHANNEL MEDICAL PARTNERS, L.P. By: /s/ Carol D. Winslow ----------------------------------- Name: Carol D. Winslow Title: Secretary Address: 5750 Old Orchard Road, Suite 310 Skokie, IL 60077 HUNT VENTURES, L.P. By: ___________________________________ Name: _________________________________ Title: ________________________________ Address: Fountain Place 1445 Ross at Field Dallas, TX ###-###-#### SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -12- CANAAN EQUITY II L.P. By: Canaan Equity Partners II LLC By: /s/ Illegible ----------------------------------- Member/Manager Address: 105 Rowayton Avenue Rowayton, CT 06853 CANAAN EQUITY II L.P. (QP) By: Canaan Equity Partners II LLC By: /s/ Illegible ----------------------------------- Member/Manager Address: 105 Rowayton Avenue Rowayton, CT 06853 CANAAN EQUITY II ENTREPRENEURS LLC By: Canaan Equity Partners II LLC By: /s/ Illegible ----------------------------------- Manager Address: 105 Rowayton Avenue Rowayton, CT 06853 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -13- CYCAD GROUP, LLC By: /s/ K. Leonard Judson ----------------------------------- Name: K. Leonard Judson Title: President and Manager Address: 6187 Carpinteria Ave., Suite 300 P.O. BOX 5010 Carpinteria, CA 93014 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -14- GUIDANT CORPORATION By: ___________________________________ Name: _________________________________ Title: ________________________________ Address: _______________________________ _______________________________ SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -15- UNICORN MEDICAL INCORPORATED By: ___________________________________ Name: _________________________________ Title: ________________________________ Address: c/o Pierre Gobin, M.D., Department of Radiology Cornell University 525 E. 68th Street Box 141 New York, NY 10021 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -16- MEDTRONIC, INC. By: /s/ Michael D. Ellwein ----------------------------------- Name: Michael D. Ellwein Title: VP & CDO Address: ______________________________ ______________________________ SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -17- ev3 INC. By: ___________________________________ Name: _________________________________ Title: ________________________________ Address: c/o Jim Corbett 1861 Buerkle Road White Bear, MN 55110 SIGNATURE PAGE TO AMENDMENT NO. 1 TO TENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT -18-