ALPINE IMMUNE SCIENCES, INC. | Business Contracts

Description of Capital Stock (Filed With SEC on March 23, 2023)

Letter Agreement, dated April 12, 2022, between Alpine Immune Sciences Inc. and AbbVie Global Enterprises Ltd. amending the Option and License Agreement, dated June 17, 2017, by... (Filed With SEC on August 11, 2022)

Executive Employment Agreement, dated as of May 27, 2022, by and between Alpine Immune Sciences, Inc. and Andrew Sandler (Filed With SEC on August 11, 2022)

License and Collaboration Agreement, dated December 15, 2021 by and between Alpine Immune Sciences, Inc. and Horizon Therapeutics Ireland DAC (Filed With SEC on March 17, 2022)

Lease Agreement, dated March 14, 2019, by and between the Company and ARE-Seattle No. 28, LLC (Filed With SEC on May 9, 2019)

Form of Stand-Alone Inducement Stock Option Grant between the Company and Andrew Sandler (Filed With SEC on November 14, 2022)

Underwriting Agreement, dated September 20, 2022, by and among Alpine Immune Sciences, Inc. and Morgan Stanley & Co. LLC, SVB Securities LLC and Cowen and Company, LLC, as... (Filed With SEC on September 21, 2022)

Separation Agreement, dated as of October 8, 2021, by and between the Registrant and Zelanna Goldberg (Filed With SEC on March 17, 2022)

Stock Purchase Agreement, dated December 15, 2021 by and between Alpine Immune Sciences, Inc. and Horizon Therapeutics Ireland DAC (Filed With SEC on March 17, 2022)

Exchange Agreement, dated September 14, 2021, by and between the Company and Frazier Life Sciences VIII, L.P (Filed With SEC on September 15, 2021)

Form of Prefunded Warrant to Purchase Common Stock (Filed With SEC on September 15, 2021)

Registration Rights Agreement, dated September (Filed With SEC on September 15, 2021)

Securities Purchase Agreement, dated September (Filed With SEC on September 15, 2021)

Executive Employment Agreement, dated June 1, 2021, by and between the Company and Zelanna Goldberg (Filed With SEC on August 10, 2021)

Form of Stand-Alone Inducement Stock Option Grant between the Company and Zelanna Goldberg (Filed With SEC on August 10, 2021)

Sales Agreement, dated as of July (Filed With SEC on July 2, 2021)

Description of Capital Stock (Filed With SEC on March 18, 2021)

Non-Employee Director Compensation Guidelines (Filed With SEC on March 18, 2021)

Option and License Agreement, dated June 17, 2020, by and between the Company and AbbVie Ireland Unlimited Company (Filed With SEC on August 11, 2020)

Form of Prefunded Warrant to Purchase Common Stock (Filed With SEC on July 24, 2020)

Form of Warrant to Purchase Common Stock (Filed With SEC on July 24, 2020)

Registration Rights Agreement, dated July 24, 2020, by and among the Company and the Purchasers (Filed With SEC on July 24, 2020)

Securities Purchase Agreement, dated July 24, 2020, by and among the Company and the Purchasers (Filed With SEC on July 24, 2020)

2018 Equity Incentive Plan, as amended (Filed With SEC on June 17, 2020)

Description of Capital Stock (Filed With SEC on March 30, 2020)

Form of Restricted Stock Unit Agreement under the 2018 Equity Incentive Plan (Filed With SEC on January 27, 2020)

Amended and Restated Loan and Security Agreement, dated August 26, 2019, by and among Alpine Immune Sciences, Inc., AIS Operating Co., Inc. and Silicon Valley Bank (Filed With SEC on August 28, 2019)

Warrant to Purchase Common Stock, dated August 26, 2019, by and between Alpine Immune Sciences, Inc. and Silicon Valley Bank (Filed With SEC on August 28, 2019)

Separation Agreement, dated April 24, 2019, by and between the Company and Mark Litton (Filed With SEC on August 13, 2019)

Alpine Immune Sciences, Inc. Executive Incentive Compensation Plan (Filed With SEC on April 1, 2019)

Alpine Immune Sciences, Inc. Non-Employee Director Compensation Guidelines (Filed With SEC on April 1, 2019)

License and Research Agreement Amendment No. 2 by and between AIS Operating Co., Inc. and Kite Pharma, Inc., effective as of October 17, 2018 (Filed With SEC on March 18, 2019)

Securities Purchase Agreement, dated January 15, 2019, by and among the Company and the Purchasers (Filed With SEC on January 16, 2019)

Form of Warrant to Purchase Common Stock (Filed With SEC on January 16, 2019)

Registration Rights Agreement, dated January 15, 2019, by and among the Company and the Purchasers (Filed With SEC on January 16, 2019)

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