First Amendment to Lease, dated January 29, 2021, between the registrant and OPG MP Parcel Owner (DE) LLC, as successor in interest to Boston Harbor Industrial Development LLC

Exhibit 10.1

645 SUMMER STREET

Boston, MA

First Amendment to Lease

Akouos, Inc.

THIS FIRST AMENDMENT TO LEASE (“First Amendment”) is made as of January 29, 2021 (the “Effective Date”) by and between OPG mp parcel owner (de) llc, a Delaware limited liability company, as successor in interest to Boston Harbor Industrial Development LLC (“Landlord”), and AKOUOS, INC., a Delaware corporation (“Tenant”). 

Background

Agreement

NOW, THEREFORE, in consideration of the foregoing and mutual covenants and agreements contained herein, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to modify and amend the Lease as follows:

Except as otherwise provided herein or except to the extent inconsistent herewith, all terms and provisions of the Lease shall be applicable to Tenant’s leasing of the Premises, including both the Existing Premises and the Expansion Premises.  Notwithstanding anything to the contrary in the Lease, Tenant shall be permitted to use up to 2,000 rentable square feet in the Expansion Premises for vivarium use, subject to all other terms and provisions of the Lease pertaining to vivarium use.    

Notwithstanding anything to the contrary in the Lease, the Term of the Lease with respect to the Existing Premises (the “Existing Premises Term”) shall be extended to be coterminous with the Expansion Premises Term.  Accordingly, the Term of the Lease with respect to the Existing Premises is hereby extended beyond the scheduled expiration date of February 19, 2028, for the period commencing on February 20, 2028 and ending on the New Expiration Date (the “Extended Existing Premises Term”).  For the avoidance of doubt, such extension shall not be deemed an exercise of Tenant’s renewal option set forth in Section 3.3 of the Lease, and Tenant shall continue to have such option to renew the term for the entire Premises.  All terms and provisions of the Lease shall apply to Tenant’s leasing of the Premises, including both the Existing Premises and the Expansion Premises, for and during the Extended Existing Premises Term, except to the extent expressly provided herein. For the avoidance of doubt, from and after the Expansion Premises Commencement Date, the Existing Premises and Expansion Premises shall be one combined Premises with one term under one Lease, and the Lease cannot be extended or terminated with respect to less than all of the Premises.

As of the Expansion Premises Commencement Date, (i) all base Building systems serving the Premises, including, but not limited to, HVAC, electrical, life safety and plumbing systems will be in good working and condition, and (ii) the Expansion Premises will be in compliance with all applicable laws, codes, and regulations, including, without limitation, the Americans with Disabilities Act.  Landlord shall warranty the Landlord Expansion Premises Work for a period of one (1) year following the Expansion Premises Commencement Date, and shall repair any defects thereto, including latent defects, of which Tenant notifies Landlord within such one (1) year period, at Landlord’s sole cost and expense (which for the avoidance of doubt, shall not be included in Operating Costs or Building Operating Expenses). With respect to items of the Landlord Expansion Premises Work covered by any contractor warranty as to which Tenant has given adequate and timely notice to Landlord, Landlord shall cause such contractor to repair any such defects pursuant to such warranty.  

In the event the Expansion Premises Delivery Date fails to occur within ninety (90) days after the Estimated Expansion Premises Commencement Date (the “Delivery Delay Penalty Date”) (as the same may be extended on account of delays caused by Tenant or Acts of God (as provided in Section 11.5 of the Lease)), then Tenant shall receive credit equal to one day’s Fixed Rent (based on the Fixed Rent scheduled to be due and payable for the Expansion Premises for Month 22 following the Rent Commencement Date) for each day from and after the Delivery Delay Penalty Date until the earlier of (i) the Expansion Premises Commencement Date, or (ii) the Second Delivery Delay Penalty Date (as defined below), such credit to be applied, at Tenant’s election by written notice delivered within thirty (30) days after the Delivery Delay Penalty Date, to the first monthly installment of Fixed Rent for the Expansion Premises due hereunder (i.e., on the Expansion Premises Rent Commencement Date and after giving effect to the application of any free rent period and the application of any amounts prepaid by Tenant) or to the first monthly installment of Fixed Rent due for the Existing Premises after the date that is thirty (30) days following the Delivery Delay Penalty Date, and in all cases if the credit is not exhausted on one month, the balance shall be carried forward to the immediately succeeding months until utilized in full.  In the event the Expansion Premises Delivery Date fails to occur within twelve (12) months after the Estimated Expansion Premises Commencement Date (the “Second Delivery Delay Penalty Date”) (as the same may be extended on account of delays caused by Tenant or Acts of God, then Tenant shall have the right to terminate this Lease by delivering written notice thereof to Landlord at any time following the Second Delivery Delay Penalty Date until the Expansion Premises Commencement Date occurs.  To the extent practicable, Landlord shall use diligent efforts to mitigate any delays caused by Acts of God.        

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* Month 1 shall begin on the Expansion Premises Rent Commencement Date (provided that if the Expansion Premises Rent Commencement Date does not occur on the first day of a calendar month, then Month 1 shall mean the partial month in which the Expansion Premises Rent Commencement Date occurs plus the following full calendar month).  For the avoidance of doubt, there is no Fixed Rent due for the Expansion Premises from the period beginning on the Expansion Premises Commencement Date and ending on the Expansion Premises Rent Commencement Date; provided, however, Tenant shall be responsible for all utility charges for the Expansion Premises from and after the Expansion Premises Commencement Date.

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** Expressed on an annualized basis even though the applicable period may be longer or shorter than twelve months.

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For the avoidance of doubt, it is acknowledged that for Months 1 – 12, the Fixed Rent is determined based on 10,000 rentable square feet, and for Months 13 – 21, the Fixed Rent is determined based on 30,000 rentable square feet, even though the Expansion Premises at all times consists of 37,500 rentable square feet.

In addition, in lieu of separate calculations and payments for Tenant’s applicable share of Operating Costs (which relate to the shared operating expenses applicable to the entire Industrial Park; hereinafter, the “Industrial Park Operating Expenses”), Insurance and Building Operating Expenses under the Original Lease, effective as of the Effective Date, the Insurance and the Building’s fair and commercially reasonable allocation of the Industrial Park Operating Expenses shall be included in Building Operating Expenses (collectively, the “Consolidated Operating Expenses”), and Tenant shall pay Tenant’s Percentage, based on a ratio of the RSF of the applicable portion of the Expansion Premises to the RSF of the Building) of the Consolidated Operating Expenses; provided that in no event shall there be an increase in the amount payable by Tenant to Landlord as compared to the amount of Operating Costs, Insurance and Building Operating Expenses payable by Tenant prior to Landlord’s implementation of Consolidated Operating Expenses, solely by reason of the use of the Consolidated Operating Expenses calculation approach.  

In furtherance of the foregoing, Tenant’s Percentage for the Expansion Premises shall be as follows (as may be adjusted from time to time to reflect changes to the Expansion Premises or the Building):

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* Month 1 shall begin on the Expansion Premises Rent Commencement Date (provided that if the Expansion Premises Rent Commencement Date does not occur on the first day of a calendar month, then Month 1 shall mean the partial month in which the Expansion Premises Rent Commencement Date occurs plus the following full calendar month).  

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* Month 1 shall begin on the Expansion Premises Rent Commencement Date (provided that if the

Expansion Premises Rent Commencement Date does not occur on the first day of a calendar month, then Month 1 shall mean the partial month in which the Expansion Premises Rent Commencement Date occurs plus the following full calendar month).  

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In addition,  Tenant shall continue to be obligated to pay all Additional Rent (including without limitation, Tenant’s Percentage of Operating Costs, Real Estate Taxes, Insurance and Building Operating Expenses with respect to the Existing Premises, and utilities for the Existing Premises) for and during the Existing Premises Term and the Extended Existing Premises Term, in accordance with the terms and provisions of the Lease, except that, effective as of the Effective Date, the Building Operating Expenses shall include the Insurance and the Building’s allocation of the Industrial Park Operating Expenses as provided above, and Tenant shall pay Tenant’s Percentage, with respect to the Existing Premises, of the Consolidated Operating Expenses in lieu of separate payments for Tenant’s applicable share of Industrial Park Operating Expenses, Insurance and Building Operating Expenses under the  Lease.  

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“Landlord shall use reasonable efforts to deliver to Tenant Landlord’s annual reconciliation statement of all Real Estate Taxes and Consolidated Operating Expenses for the preceding calendar year (collectively, “Expenses”) within one hundred twenty (120) days after the end of each year (but in no event later than three hundred sixty-five (365) days after the end of each year), which statement shall include reasonable supporting explanation and documentation.  Within ninety (90) days after receipt of Landlord’s annual reconciliation statement (each such period is referred to as the “Review Notice Period”), Tenant may give Landlord written notice (“Review Notice”) that Tenant (including, without limitation, Tenant’s Auditors (as defined below)) intends to review Landlord’s records of the Expenses for the year to which the statement applies (the “Request for Information”).  Within a reasonable time after Landlord’s receipt of a timely Request for Information and executed Audit Confidentiality Agreement (referenced below), Landlord, as determined by Landlord, shall forward to Tenant (and Tenant’s Auditors), or make available for inspection on site at such location deemed reasonably appropriate by Landlord (which shall be within the Boston area), such records (or copies thereof) for the applicable year that are reasonably necessary for Tenant (including, Tenant’s Auditors) to conduct its audit of the information set forth

in the annual reconciliation statement.  Within ninety (90) days after all applicable records are made available to Tenant (such period is referred to as the “Objection Period”), Tenant shall have the right to give Landlord written notice (an “Objection Notice”) stating in reasonable detail any objection to Landlord’s statement of Expenses for that year which relates to the records that have been made available to Tenant.  If Tenant provides Landlord with a timely Objection Notice and the parties agree that Expenses for the calendar year are less than reported, then Landlord shall provide Tenant with a credit against the next installment of Rent in the amount of the overpayment by Tenant or refund such amount within thirty (30) days if the Term has then ended.  If the parties agree that Expenses for the calendar year are greater than reported, Tenant shall pay Landlord the amount of any underpayment within thirty (30) days.  In the event of a good faith disagreement with respect to whether Expenses for a calendar year are less than or more than that reported, Landlord and Tenant shall appoint a mutually acceptable independent auditor (the “Independent Auditor”) to resolve such disagreement, and the findings of the Independent Auditor shall be binding and conclusive on the parties and the fees of such independent auditor shall be shared equally by Landlord and Tenant.  If Landlord and Tenant cannot mutually agree as to the identity of the Independent Auditor, then the Independent Auditor shall be one of the "Big 4" accounting firms selected by Tenant which is not paid on a contingency basis.   If Tenant retains an agent to review Landlord’s records, the agent must be with a certified public accounting firm licensed to do business in the state or commonwealth where the Building is located.  Tenant shall be solely responsible for all costs, expenses and fees incurred for the audit, provided that if any such audit reveals an overstatement of Expenses in excess of five percent (5%), then Landlord shall reimburse Tenant on demand for all of the costs of such audit, and in addition, notwithstanding the above, Landlord shall be responsible for all costs of the Independent Auditor.  Tenant shall not directly or indirectly engage such agent or any other party in connection with such review whose compensation or fees are charged in whole or in part on a contingency basis.  The records and related information obtained by Tenant shall be treated as confidential (except as required by law or to the extent required to be disclosed to enforce Tenant’s rights hereunder) by Tenant and its auditors, consultants and other parties reviewing such records on behalf of Tenant (collectively, “Tenant’s Auditors”), and, prior to making any records available to Tenant or Tenant’s Auditors, Landlord may require Tenant and Tenant’s Auditors to each execute a commercially reasonably confidentiality agreement in a form reasonably provided by Landlord (“Audit Confidentiality Agreement”) in accordance with the foregoing.  In no event shall Tenant be permitted to examine Landlord’s records or to dispute any statement of Expenses unless Tenant has paid and continues to pay all Rent when due.”

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Notice Address

For Landlord:OPG MP Parcel Owner (DE) LLC

c/o Oxford Properties Group

125 Summer Street

Boston, MA 02110

Attention:  Leasing

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OPG MP Parcel Owner (DE) LLC

c/o Oxford Properties Group

125 Summer Street

Boston, Massachusetts 02110

Attention:  Legal”

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From the Expansion Premises Commencement Date through the New Expiration Date (as defined in the First Amendment), the ‘Premises’ shall consist of (a) the Existing Premises and (b) that portion of the Building containing 37,500 rentable square feet, consisting of the entire southern half of the first (1^st) floor of the Building, as shown on Exhibit A-1 to the First Amendment (the ‘Expansion Premises’).”

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“Tenant shall have, as appurtenant to the Premises, rights to use, and permit its invitees to use, in common with Landlord and other tenants and occupants of the Property, subject to reasonable rules and regulations from time to time made by Landlord of which Tenant is given notice: (a) the common lobbies, toilets and corridors of the Building and the pipes, ducts, conduits, wires and appurtenant fixtures serving the Premises as more particularly described in the Work Letter attached as Exhibit B hereto and Exhibit B to the First Amendment, (b) common walkways and driveways necessary for access to the Building, and (c) to the extent the Landlord, in its discretion, provides the following for the non-exclusive use of the tenants and occupants of the Property from time to time, the onsite cafe, Building showers and lockers, Building common mother's room, secured, covered bicycle storage, rooftop shuffleboard courts as in existence as of the date hereof, all of which, to the extent the same are provided for the non-exclusive use of the tenants and occupants of the Property from time to time, are hereinafter known as the “Common Areas.  

During the Term, Tenant shall lease from Landlord, and Landlord shall lease to Tenant, or cause the operator (the “Operator”) of the parking lots serving the Building (the “Parking Facilities”) to lease to Tenant, sixty-four (64) unreserved parking spaces in the locations designated by Landlord within the Parking Facilities (the “Spaces”) for the use of Tenant and its employees, agents and invitees.  Tenant shall not have the right to lease or otherwise use more than the number of unreserved Spaces set forth above.  The Spaces shall be leased at the then-current rate for unreserved spaces in the Parking Facilities, as such rate may be adjusted from time to time, reflecting the then-current rate charged to monthly parkers parking in the Parking Facilities (the “Parking Fee”), which shall be no more than the prevailing parking rate for comparable parking facilities in Boston’s Seaport District.  As of the Effective Date, the current Parking Fee is $200.00 per unreserved Space, per month.  Prior to any increase to the Parking Fee, Landlord shall provide Tenant with at least thirty (30) days prior written notice of such increase.  No deductions or allowances shall be made for days when Tenant or any of its employees, agents or invitees do not utilize the Parking Facilities or for Tenant utilizing less than all of the Spaces then leased by Tenant.  In addition to the lease of the Spaces, Tenant shall also have the right to lease additional unreserved parking spaces in the Parking Facilities on a month-to-month basis (“Month-to-Month Spaces”) for the use of Tenant and its employees, agents and invitees, subject to such Month-to-Month Spaces being available for lease as determined by Landlord in Landlord’s sole discretion.  Each Month-to-Month Space shall be leased at the Parking Fee, per month.  If requested by Landlord, Tenant shall execute and deliver to Landlord a commercially reasonable parking agreement for any such Month-to-Month Spaces.  As

used herein, the “Tenant Parking” shall collectively refer to (i) the Spaces and (ii) any Month-to-Month Space(s) during any time that Tenant is leasing any Month-to-Month Space(s).  Landlord reserves the right upon thirty (30) days prior written notice to Tenant to relocate any of the Month-to-Month Space(s) to other parking areas or facilities in the Industrial Park within reasonable proximity of the Building.  

Tenant shall have exclusive use of the loading dock shown on page 2 of Exhibit A-1 to the First Amendment (the “Tenant’s Exclusive Loading Dock”).  Tenant’s Exclusive Loading Dock shall be deemed a part of the Premises for all purposes herein.  Landlord shall be responsible for performing all maintenance, repair and replacements for Tenant’s Exclusive Loading Dock and Tenant’s Exclusive Freight Elevator (as defined below).  All costs of such maintenance and repair to Tenant’s Exclusive Loading Dock and Tenant’s Exclusive Freight Elevator that are not capital in nature shall be included within Building Operating Expenses subject to Section 5.2.4 of the Lease, provided that Tenant’s Percentage of such costs shall be 100%.  Capital repairs and replacements to the Tenant’s Exclusive Loading Dock and Tenant’s Exclusive Freight Elevator shall be made by Landlord at its sole cost and expense without reimbursement by Tenant, except for capital repairs or replacements required by any applicable laws not in existence as of the Expansion Premises Commencement Date (as defined in the First Amendment), which shall be included in the Building Operating Expenses pursuant to Section 5.2.4, provided that Tenant shall be 100% responsible for each annual portion as so amortized).  Landlord currently does not charge a fee for use of Tenant’s Exclusive Loading Dock or Tenant’s Exclusive Freight Elevator; however, if Landlord determines that Tenant is using such facilities in a manner that poses a security concern for the Building and/or the tenants and occupants thereof or in a manner that is not in compliance with Landlord’s reasonable rules, regulations and protocols, then Landlord reserves the right to employ security detail for any such use by Tenant, and in such event Landlord shall give Tenant written notice thereof and Tenant shall pay the actual reasonable cost charged by such security vendor within thirty (30) days of an invoice from time to time.  Tenant shall have exclusive use of the freight elevator shown on page 2 of Exhibit A-1 to the First Amendment (the “Tenant’s Exclusive Freight Elevator”), 24 hours per day, 7 days per week, 365 days per year.  Tenant shall have access to and use of the Premises, the Common Areas, and Tenant’s Exclusive Loading Dock 24 hours per day, 7 days per week, 365 days per year.  The normal business hours for the Building are 8:00am to 6:00pm Monday through Friday, except for holidays.  Landlord represents that, as of the Effective Date of the First Amendment, Verizon telecommunications and cabling services are available at the Building.”

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“Notwithstanding anything to the contrary contained in this Lease, (a) during the Existing Premises Term and Extended Existing Premises Term, Tenant shall be entitled to the allocation of 50.00% (37,500 divided by 75,000) of the maximum allowable chemical

quantities (both in use and in storage) permitted by MAQ Codes (defined below) for the second (2^nd) floor of the Building, which maximum allowable chemical quantities for the entire second (2^nd) floor is 240 liquid gallons, subject to Tenant maintaining all licenses, permits and approvals required therefor, and (b) during the Expansion Premises Term, Tenant shall be entitled to the allocation of 50.00% (37,500 divided by 75,000) of the maximum allowable chemical quantities (both in use and in storage) permitted by MAQ Codes for the first (1^st) floor of the Building, which maximum allowable chemical quantities for the entire first (1^st) floor is 240 liquid gallons, subject to Tenant maintaining all licenses, permits and approvals required therefor.  As used herein, “MAQ Codes” shall mean 780 CMR – Massachusetts State Building Code 9^th Edition, 527 CMR – Massachusetts Comprehensive Fire Safety Code, and NEPA 45 – Standard on Fire Protection for Laboratories Using Chemicals, 2011 Edition.”

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Landlord and Tenant acknowledge and agree that Tenant’s right to tie the Premises into the base building pH neutralization system (the “pH Neutralization System”) shall include the Expansion Premises, and the actual monitoring, repair and maintenance costs of the pH Neutralization System shall be passed through to Tenant on a pro-rata basis, based upon the proportion that the rentable square footage of the Premises (including the Existing Premises, and from and after the Expansion Premises Rent Commencement Date, the Expansion Premises) bears to the total rentable square footage of all tenant-occupied space tied into the pH Neutralization System.  

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“Without the consent of Landlord, Tenant’s use of electrical service shall not exceed the Building’s standard capacity, as reasonably determined by Landlord, based upon the Building standard electrical design load. Landlord represents and warrants to Tenant that the Building’s standard capacity is 4000 amp, 480/277 volt electrical service and can accommodate lab tenants with an approximate 50-50 split between office and laboratory use within each tenant premises located on the first floor of the Building.  The electrical load for lighting, receptacle and ventilation allocated in each tenant premises is 6 va per square foot for office space, and 12 va per square foot for laboratory space.”

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“Notwithstanding anything to the contrary, Landlord may, within ten (10) business days after submission of Tenant’s written request for Landlord’s consent to any assignment of this Lease or any sublease for more than fifty percent (50%) of the Premises for the remainder of the Term, elect to cancel this Lease as to the portion of the Premises proposed to be sublet or assigned as of the date the proposed transfer is to be effective by written notice to Tenant.  If Landlord exercises such right of recapture, then Tenant may within ten (10) business days after receipt of Landlord’s notice elect to withdraw its request for assignment or sublet, and in such event the Lease shall continue in full force and effect.  If Tenant does not timely elect to withdraw its request, this Lease shall automatically be

amended (or terminated if the entire Premises is being assigned or sublet) to delete the applicable portion of the Premises effective on the proposed effective date of the transfer, although Landlord may require Tenant to execute a reasonable amendment or other document reflecting such reduction or termination.  If Landlord elects to recapture any space, Landlord, at its sole cost and expense, shall construct or cause to be constructed a demising wall separating that portion of the Premises recaptured by Landlord from that portion of the Premises retained by Tenant. For the avoidance of doubt, Landlord’s recapture and profit sharing rights shall not apply with respect to Permitted Transfers or any other transaction not requiring Landlord’s consent.”  

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In addition, the second paragraph of Section 6.2.1 of the Lease is hereby deleted in its entirety and replaced with the following:

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“Notwithstanding anything to the contrary contained in this Lease, subject to the approval by Massport and provided that no event of Tenant default hereunder then exists beyond any applicable grace or cure period, Tenant may, without Landlord’s prior written consent, but upon prior notice to Landlord (or with notice to be provided as soon as possible thereafter if Tenant is prevented from disclosing as a result of applicable securities laws or regulations restricting disclosure or confidential agreements preventing any earlier notification), sublet all or any portion of the Premises or assign this Lease to: (a) a subsidiary, affiliate, parent or other entity to Tenant which controls, is controlled by, or is under common control with, Tenant; (b) a successor entity to Tenant resulting from merger, consolidation or non-bankruptcy reorganization; or (c) a purchaser of all or substantially all of Tenant’s assets or stock (each a “Permitted Transfer”); provided that, in order for any transfer described in the foregoing clause (b) or clause (c) to qualify as a Permitted Transfer, (i) the successor to Tenant must have a tangible net worth computed in accordance with generally accepted accounting principles at least equal to the tangible net worth of Tenant immediately prior to such transfer, and (ii) if requested by Landlord, proof satisfactory to Landlord of such tangible net worth shall have been delivered to Landlord.  Landlord shall not be entitled to any assignment/sublease profits or rights of recapture in connection with a Permitted Transfer or any other transaction not requiring Landlord’s consent.”

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Notwithstanding any provision herein to the contrary, so long as (A) Tenant shall not be, or have been, in monetary or material non-monetary default beyond applicable notice and cure periods under this Lease as of the applicable Reduction Date, (B) this Lease is still in full force and effect, and (C) Tenant provides Landlord with written notice requesting the same (requirements (A) through (C), collectively, the “Letter of Credit Reduction Conditions”), then Tenant shall be entitled to reduce the required amount of the Expansion Premises Letter of Credit to the amounts and at the times set forth below, and Tenant may thereafter deliver to Landlord a substitute or amended Expansion Premises Letter of Credit, conforming to the requirements hereof, in the sum of such reduced amount (Landlord agrees to reasonably cooperate with Tenant in connection with any amendment to the Expansion Premises Letter of Credit).  Upon Tenant complying with the Letter of Credit Reduction Conditions set forth above, the required amount of the Expansion Premises Letter of Credit shall be reduced in accordance with the following schedule:

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Upon and as a condition to each such reduction, Tenant shall deliver to Landlord a substitute or amended Expansion Premises Letter of Credit, conforming to the requirements hereof, in the sum of the reduced Expansion Letter of Credit amount. Whereupon, if a substitute Expansion Premises Letter of Credit is provided, Landlord shall surrender to Tenant the existing

Expansion Premises Letter of Credit being so replaced within ten (10) business days; provided, however, that in no event shall the amount of the Expansion Premises Letter of Credit hereunder ever be less than $693,750.00.  Upon Landlord’s receipt of a substitute Expansion Premises Letter of Credit in compliance with Exhibit C, Landlord agrees not to draw upon the Expansion Premises Letter of Credit being so replaced.  Notwithstanding anything to the contrary, Tenant acknowledges that upon the occurrence of any monetary or material non-monetary default beyond applicable notice and cure periods under the Lease (as amended hereby), Tenant shall not be entitled to any further reduction in the amount of the Letter of Credit, and Tenant’s Letter of Credit obligation shall not be reduced below its then current level.  

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(h)Massport Consent.  Landlord represents and warrants to Tenant that Landlord has received the prior written consent of Massachusetts Port Authority to this First Amendment, a copy of which has been provided to Tenant.

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(i)Mortgages.  As of the date of this First Amendment, Landlord represents and warrants to Tenant that there is no existing mortgage, trust deeds, or ground lease encumbering the Premises, the Building, the Property or the Industrial Park other than the ground lease with Massachusetts Port Authority and a mortgage with TD Bank, N.A.  Simultaneous with the full execution of this First Amendment, Landlord shall obtain and deliver to Tenant a fully executed non-disturbance agreement from TD Bank, N.A. in the form attached hereto as Exhibit E.  Notwithstanding anything to the contrary, if during the Term of this Lease, there is a future mortgage, trust deed, or ground lease encumbering all or any portion of the Premises, the Building, the Property or the Industrial Park Landlord agrees, as a condition to subordination of this Lease to such mortgage, trust, deed or ground lease, to cause the holder of such mortgage or trust deed, or ground lessor of such ground lease to enter into a commercially reasonable form of subordination, non-disturbance and attornment agreement with Tenant with respect to this Lease, the form of which shall be a commercially reasonable form provided by the mortgagee, trust deed holder or ground lessor (provided the same recognizes Tenant’s rights under this Lease, subject to such commercially reasonable terms and conditions as provided in such agreement), incorporating such commercially reasonable modifications requested by Tenant and reasonably approved by the holder of such mortgagee or trust deed or ground lessor.

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[signature page follows]

IN WITNESS WHEREOF, Landlord and Tenant have entered into this First Amendment as of the Effective Date set forth above. 

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Exhibit B

Expansion Premises Work Letter

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This Exhibit is attached to and made a part of the First Amendment to Lease (“First Amendment”) by and between OPG MP PARCEL OWNER (DE) LLC, a Delaware limited liability company (“Landlord”), and AKOUOS, INC., a Delaware corporation (“Tenant”), for space in the Building located at 645 Summer Street, Boston, MA 02210.  Capitalized terms used but not defined herein shall have the meanings given in the First Amendment.

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B.1General.  Any Tenant Expansion Premises Work (as hereinafter defined) shall be constructed by Tenant in accordance with, and subject to, the terms and conditions set forth in Section 6.2.4 of the Lease and this Exhibit B.  Except for Landlord’s Expansion Premises Work, Landlord shall not be responsible for any aspects of the design or construction of the Tenant Expansion Premises Work, the correction of any defects therein, or any delays in the completion thereof.  The “Tenant Expansion Premises Work” shall mean all alterations, repairs, additions, installations or improvements to be performed in or about the Expansion Premises that are required initially to put the Expansion Premises in condition suitable for Tenant’s use and occupancy.

B.2Landlord’s Work.  Landlord shall, at its sole cost and expense, perform the base building work for the Expansion Premises listed in the “Landlord” column on the Landlord / Tenant Responsibility Matrix attached hereto as Schedule B-1 (the “Landlord Expansion Premises Work”) in accordance with Landlord’s Construction Plans and otherwise in a good and workmanlike manner and in compliance with all applicable laws, codes, and regulations.  As of the Effective Date, the plans for Landlord’s Expansion Premises Work are described on Schedule B-3 (“Landlord’s Construction Plans”), a true, accurate and complete copy of which were provided to Tenant by Landlord via email on January 5, 2021.  Landlord shall not make any changes to the portions of Landlord’s Construction Plans pertaining to the air handler for the Expansion Premises or the size or location of the mechanical room within the Expansion Premises without Tenant’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed.   Landlord shall use reasonable efforts to substantially complete the Landlord Expansion Premises Work on or before the Estimated Expansion Premises Commencement Date.  Notwithstanding the foregoing or anything to the contrary, Landlord shall not furnish and install the blinds until after all other Landlord Expansion Premises Work by Landlord and all Tenant Expansion Premises Work by Tenant, is complete, and such furnishing and installation of blinds shall not be conditions of the Expansion Premises Delivery Date or Substantial Completion of the Landlord Expansion Premises Work or the Commencement Date (provided that Landlord agrees to furnish and install the blinds  promptly upon the completion of the Tenant Expansion Premises Work (not to exceed thirty (30) days following the completion of the Tenant Expansion Premises Work)).  

For purposes hereof, “Substantially Complete” and “Substantial Completion” shall mean that the Landlord Expansion Premises Work has been completed, other than minor punchlist-type items the completion of which will not unreasonably delay or interfere with Tenant’s performance of the Tenant Expansion Premises Work or (as applicable) Tenant’s occupancy and use of the Expansion Premises for the regular conduct of business, and other than the furnishing and installation of blinds, with Landlord’s receipt of any municipal approvals or sign-offs needed in order for Tenant to perform the Tenant Expansion Premises Work, if any (but, for the avoidance

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of doubt, excluding any permits that cannot be issued until the completion of the Tenant Expansion Premises Work, whereupon, Tenant shall obtain the certificate of occupancy (and Landlord agrees to cooperate with Tenant in obtaining same)).  For the avoidance of doubt, it shall be a condition to Substantial Completion that Landlord has properly completed all work necessary in order for Tenant, once Tenant completes the Tenant Expansion Premises Work, to obtain a certificate of occupancy.  Landlord and Tenant shall conduct a final walk-through of the Landlord’s Expansion Premises Work not earlier than ten (10) days prior to the expected date of Substantial Completion of the Landlord’s Expansion Premises Work, as specified by prior written notice from Landlord to Tenant (which notice shall be delivered at least ten (10) days prior to the expected walk-through), and shall each prepare a punch list.  Landlord and Tenant shall meet in good faith to create one unified list of punchlist-items.  Landlord shall use commercially reasonable efforts to complete all minor punchlist-type items within thirty (30) days after Substantial Completion of the Landlord Expansion Premises Work, and if any such minor punchlist-type item cannot reasonably be completed within such 30-day period, then as soon as is reasonably practicable thereafter (but not to exceed sixty (60) days after Substantial Completion of the Landlord Expansion Premises Work, except to the extent a longer period is reasonably needed due to seasonal conditions, Acts of God, or any delays caused by Tenant).  

B.3Tenant’s Construction Documents.  Tenant shall prepare, at Tenant’s expense (subject to reimbursement from the Expansion Premises Allowance), and deliver to Landlord the final construction documents for the Tenant Expansion Premises Work (including any electronic, fiber, phone and data cabling and related equipment to be installed by or for the exclusive benefit of Tenant) in accordance with Section 6.2.4 of the Lease and the requirements listed on Schedule B-2 attached hereto (the “Construction Documents”).  Tenant shall retain a qualified architect who is experienced in the design of comparable lab and office tenant space in comparable buildings and licensed in the state or commonwealth in which the Building is located, to prepare the Construction Documents for the Tenant Expansion Premises Work.  Tenant shall also retain, or cause its architect to retain, the services of the electrical and mechanical engineers engaged by Landlord for the Building or such other experienced engineers as are otherwise reasonably approved by Landlord (such approval not to be unreasonably withheld, conditioned or delayed), as well as Landlord’s structural engineer if any portion of Tenant Expansion Premises Work affects structural components of the Building.  Even if any such architect or engineers may have been otherwise engaged by Landlord in connection with the Building, Tenant shall be solely responsible for the liabilities and expenses of all architectural and engineering services relating to the Tenant Expansion Premises Work (subject to reimbursement from the Expansion Premises Allowance as provided below) and for the adequacy and completeness of the Construction Documents submitted to Landlord.  Except as otherwise provided herein, the Construction Documents shall comply with the Building’s construction rules and regulations (but only to the extent provided to Tenant), including without limitation those designed to maintain a uniform exterior appearance of the Building.  A true, correct complete copy of the Building’s current construction rules and regulations in effect as of the Effective Date has been provided to Tenant via email prior to the Effective Date.  In the event of any inconsistency between the terms and conditions of the Building’s construction rules and regulations and this Expansion Premises Work Letter, the terms and conditions of this Expansion Premises Work Letter shall control.  Tenant shall be solely responsible for the timely preparation and submission to Landlord of the Construction Documents.  Landlord shall review and approve (such approval not to be unreasonably withheld, except that

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items that affect the structural elements or systems of the Building shall be subject to Landlord’s approval in Landlord’s sole discretion, and non-customary office/laboratory installations that are visible from the exterior of the Premises shall be subject to Landlord’s reasonable approval in Landlord reasonable discretion) (or provide reasonable (to the extent provided in the foregoing parenthetical) comments on) the Construction Documents, in a written response, within ten (10) Business Days after the same are delivered to Landlord, provided that Landlord reserves the right to extend such review period for an additional five (5) Business Days if reasonably required to review, or to cause Landlord’s third-party engineer(s) to review, any structural elements or other special elements of the Tenant Expansion Premises Work.  In the event that Landlord fails to respond within the time periods above, Tenant may deliver a second written notice, which second written notice shall include the following language in bold, 14-point font and all caps, “ATTENTION:  FAILURE BY LANDLORD TO RESPOND WITHIN THREE (3) BUSINESS DAYS OF RECEIPT OF THIS NOTICE SHALL CONSTITUTE DEEMED APPROVAL BY LANDLORD OF THE SUBJECT OF THIS NOTICE” (any such second written notice with such required language in bold, 14-point font and all caps, a “Deemed Approval Reminder”), and if Landlord fails to respond within three (3) Business Days of delivery of such Deemed Approval Reminder, then Landlord’s approval of the subject of such Deemed Approval Reminder shall be deemed granted.  Tenant shall promptly cause the Construction Documents to be corrected or revised to address Landlord’s reasonable (to the extent provided herein) comments and resubmitted to Landlord for its review and approval as provided above (provided that such period for review shall be five (5) Business Days and Landlord shall have no right to object to any previously approved component of the Construction Documents that is not materially affected by a change shown in the revised Construction Documents).  

B.4Expansion Premises Allowance.  Landlord shall provide Tenant with an allowance in an amount not to exceed $7,125,000.00 (based on $190.00 per rentable square foot in the Expansion Premises) (such amount sometimes being referred to herein as the “Expansion Premises Allowance”) for the costs of constructing the Tenant Expansion Premises Work in the Expansion Premises for Tenant’s initial occupancy, provided that Tenant may apply up to twenty-five percent (25%) of the Expansion Premises Allowance (i.e., $1,781,250.00) (the “Existing Premises Costs Cap”) toward the costs of any improvement work to the Existing Premises (the “Tenant Existing Premises Work”), which Tenant Existing Premises Work shall be subject to the same terms and conditions hereunder with respect to the Tenant Expansion Premises Work.  The costs of the Tenant Expansion Premises Work and any Tenant Existing Premises Work (collectively, the “Tenant Work”), including, without limitation, the so-called soft costs of architectural and engineering fees and third-party project management fees with respect thereto, are collectively referred to herein as, the “Allowance Costs”.  All Tenant construction and design costs for the Premises in excess of the Expansion Premises Allowance, and all construction and design costs for the Existing Premises in excess of the Existing Premises Costs Cap, shall be paid for entirely by Tenant, and Landlord shall not provide any reimbursement therefor.  The Expansion Premises Allowance shall be disbursed as requisitioned by Tenant, but not more than one requisition per month.  Tenant may requisition not more than twenty percent (20%) of the Expansion Premises Allowance (i.e., $1,425,000.00) for the soft costs for the Tenant Work described above.  For each disbursement, Tenant shall submit a requisition package to Landlord prior to the first day of the month, with an itemization of the costs being requisitioned, a certificate by an officer of Tenant that all such costs are Allowance Costs and have been incurred and paid for by Tenant and stating

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the applicable phase of the Tenant Work for which such costs were incurred and the square footage of the portion of the Premises being improved in such phase, and appropriate back-up documentation including, without limitation, customary AIA forms of progress payment certifications and lien releases for contractors charging more than $10,000 (in a customary form provided or reasonably approved by Landlord), and copies of paid invoices and bills.  Prior to commencing the Tenant Work, Tenant shall provide Landlord with an itemized budget for the Allowance Costs for Landlord’s review (but not approval), and Tenant’s construction schedule, including any phasing plan, for the Tenant Work.  If the total Allowance Costs for the Tenant Work are reasonably estimated to exceed the Expansion Premises Allowance, Landlord reserves the right to make pro-rata disbursements of the Expansion Premises Allowance for each requisition, in the ratio that the Expansion Premises Allowance bears to the total estimated Allowance Costs, subject to a final reconciliation of the Expansion Premises Allowance upon completion of the work.  In addition, in the event that Tenant performs the Tenant Work in phases, then for each such phase, Tenant may only requisition from a pro-rata portion of the Expansion Premises Allowance based on the percentage of the cost of the Tenant Work being performed in such phase, provided that Tenant may not requisition more than $190.00 per rentable square foot of the portion of the Premises being improved in any particular phase, until final completion of all Tenant Work and subject to final reconciliation of the Expansion Premises Allowance (for illustration purposes only, if Tenant elects to perform the Tenant Work in four phases, with each phase consisting of twenty-five percent (25%) of the cost of the Tenant Work, with the first phase improving 7,500 square feet of the Expansion Premises and each of the subsequent three phases improvement 10,000 square feet of the Expansion Premises, then Tenant may requisition only up to $1,425,000.00 during the first phase, and up to $1,781,250.00 during each subsequent phase, until and subject to a final reconciliation of the Expansion Premises Allowance upon completion of all Tenant Work.  It being acknowledged that some portions of the Tenant Work may cost more or less than $190 per rentable square foot, and Tenant shall nevertheless be entitled to the full amount properly requisitioned hereunder upon the final reconciliation (without giving effect to the $190 per rentable square foot cap described above)).  Landlord further reserves the right to fund the final ten percent (10%) of the Expansion Premises Allowance for each phase within thirty (30) days after Tenant’s submission to Landlord of the Close-Out Materials for such phase.  The “Close-Out Materials” shall mean the requisition package for the final amount of the Expansion Premises Allowance for such phase as provided above, together with (i) a final AIA certificate from Tenant’s architect evidencing substantial completion of the Tenant Expansion Premises Work for such phase in accordance with the approved Construction Documents, (ii) a set of “as built” or final record plans for such work, (iii) final lien waivers for such work from all contractors, subcontractors, and other parties who would be entitled to a lien on the Building if not paid, (iv) a certificate of occupancy for the Premises after the performance of such work, and (v) any other items required under the Building’s construction rules and regulations for closing out the particular work in question.  Tenant may use any portion of Expansion Premises Allowance up to the Existing Premises Costs Cap, toward the cost of the Tenant Existing Premises Work until the date that is twelve (12) months after the Expansion Premises Rent Commencement Date.  Tenant shall not be entitled to any unused portion of the Expansion Premises Allowance that is not requisitioned within thirty (30) months after the Expansion Premises Rent Commencement Date.  Landlord shall have no obligation to disburse any portion of the Expansion Premises Allowance at any time when there exists a Default under the Lease (or for so long as an event or condition has occurred which with notice and the passage of time would constitute such a Default), until such time as the Default

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(or the event or condition) has been cured by Tenant, at which time the withheld disbursement for any valid requisition hereunder shall be made in accordance with the terms hereof.

B.5Tenant’s Performance of the Work.  The Tenant Work shall be performed and constructed by Tenant in accordance with the approved Construction Documents, in compliance with applicable laws, and the provisions of the Lease, including without limitation the terms and conditions of Section 6.2.4 thereof and the Building’s construction rules and regulations, using contractors reasonably acceptable to Landlord (provided that Landlord may reasonably designate specific contractors with respect to work affecting base building systems, and provided further that it shall be reasonable for Landlord to require any contractor or subcontractor performing work on or about the Premises or Building to employ union labor and any construction manager utilized by Tenant to be a union-associated construction manager).  Any structural work (to the extent, if any, required to reinforce portions of the floor of the Premises for Tenant’s filing rooms or similar uses requiring additional support) or other work affecting base building systems or areas outside the Premises shall be done only after obtaining Landlord’s reasonable prior approval of Construction Documents therefor and of the manner in which such work shall be performed, specifically including any Landlord requirements concerning access to adjacent tenant areas or Building core areas.  Landlord shall not be responsible for any aspects of the design or construction of the Tenant Expansion Premises Work, any Tenant Existing Premises Work or other Tenant installations in or about the Premises, the correction of any defects therein, or any delays in the completion thereof.  After the Construction Documents have been approved by Landlord, any change in the work shown thereon shall be made only after Tenant shall have submitted revised Construction Documents to Landlord for its review and approval in accordance with Paragraph B.3 above, provided that Landlord’s approval shall not be required for Minor Variations.   “Minor Variations” shall mean any modifications that are reasonably required: (i) to comply with all applicable legal requirements enacted after the date of this First Amendment and/or to obtain or to comply with any required permit, (ii) to comport with good design, engineering, and construction practices which are not material, or (iii) to make reasonable adjustments for field deviations or conditions encountered during the construction of the Tenant Work; provided that such modifications do not affect any structural elements or systems of the Buildings and are not visible from the exterior of the Premises.  Notwithstanding the foregoing, Landlord’s prior approval shall not be required for design modifications visible from the exterior of the Premises that would otherwise qualify as Minor Variations, so long as the same are consistent with the aesthetic, quality and standard of the Building, and are not unsightly, offensive, improper, untoward or obscene, and do not involve political or moral matters and are otherwise content-neutral; provided, however, that Landlord shall have the right to require that Tenant remove any such visible modifications in the event of any such removal request or complaint by governmental authority or community action, or in the event of more than one such removal request or complaint by other tenants or occupants of the Building or surrounding neighborhood. If the Tenant Expansion Premises Work or any Tenant Existing Premises Work includes any structural or other special items, Tenant shall reimburse Landlord for the reasonable third party out-of-pocket costs incurred by Landlord in reviewing such items.  Tenant shall pay to Landlord or its managing agent a fee for Landlord’s administrative oversight and coordination of the Tenant Work in an amount equal to 1.5% of the Expansion Premises Allowance; provided, however, that if Tenant elects for Landlord to manage the construction of the Tenant Work, then such fee shall instead be in an amount equal to 5% of the Expansion Premises Allowance.  In addition, Tenant shall pay to Landlord the costs of Building services or facilities (such as electricity, HVAC, fire alarm plug ins/outs, and cleaning) used by

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Tenant in connection with its performance of the Tenant Work, in each case at Building standard rates charged to tenants generally; provided that there shall be no charge for freight elevator service.  Any such costs shall constitute Allowance Costs that may be requisitioned from time to time from the Expansion Premises Allowance as provided in Paragraph B.4.  

B.6Construction Representatives.  Tenant hereby designates Dan Paquette to serve as Tenant’s Authorized Representative, who shall have full power and authority to act on behalf of Tenant on any matters relating to the Tenant Work.  Tenant may from time to time change the Tenant’s Authorized Representative or designate additional Tenant’s Authorized Representative(s) by written notice delivered to Landlord in accordance with the Lease.  Landlord hereby designates Nicole Looney to serve as Landlord’s Authorized Representative, who shall have full power and authority to act on behalf of Landlord on any matters relating to the Tenant Work.  Landlord may from time to time change the Landlord’s Authorized Representative or designate additional Landlord’s Authorized Representative(s) by written notice delivered to Tenant in accordance with the Lease.

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Schedule B-1

Landlord / Tenant Responsibility Matrix

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Schedule B-2

Requirements for Construction Documents for Tenant Work

1.Preparation of Construction Documents. The Construction Documents shall include all architectural, mechanical, electrical, fire protection, plumbing and structural drawings and detailed specifications for the Tenant Work, as applicable, and shall show and/or specify all work necessary to complete the Tenant Work including all cutting, fitting, and patching and all connections to the mechanical and electrical systems and other components of the Building as well as any re-balancing and re-commissioning scope that is necessary to address Base Building systems affected by the Tenant Work. Where the Tenant Work interfaces with Base Building, the Tenant Work design shall visually integrate with the Base Building in a manner and with materials and finishes that are compatible with the Base Building in that area. Landlord reserves the right to reject Construction Documents which in its reasonable opinion fail to comply with this provision. The Construction Documents shall include but not be limited to:

(a)Major Work Information: A list of any items or matters which might require structural modifications to the Building, including but not limited to the following:

(b)Plans Submission: Two (2) blackline drawings and one (1) CAD disk (subject to Tenant’s architect’s and its consultants’ and subconsultants’ reasonable conditions for re-use) showing all architectural, mechanical and electrical systems, including cutsheets (where reasonably requested by Landlord), specifications and the following:

CONSTRUCTION PLANS:

(1)All partitions shall be shown; indicate ratings of all partitions; indicate all non-standard construction and details referenced;

REFLECTED CEILING PLAN:

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down lights, special lighting fixtures, special return air registers, special supply air diffusers, and special wall switches.

TELECOMMUNICATIONS AND ELECTRICAL EQUIPMENT PLAN:

DOOR SCHEDULE:

HVAC:

ELECTRICAL:

PLUMBING:

ROOF:

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Detailed plan of any existing and proposed roof equipment, if any, showing location and elevations of all equipment.

SPECIAL SERVICES:

Equipment cuts (where reasonably requested by Landlord), power requirements, heat emissions, raised floor requirements, fire protection requirements, security requirements, and emergency power.

2.Plan Requirements. The Construction Documents shall be fully detailed and fully coordinated with each other and with the Base Building design, shall show complete dimensions, and shall have designated thereon all points of location and other matters, including special construction details and finish schedules. Tenant and its architect shall be solely responsible for ascertaining all existing field conditions; provided that Landlord agrees to provide any plans in Landlord’s files. Any plans in Landlord’s files, if any, that are provided to Tenant shall be without any representation or warranty. All drawings shall be uniform size, shall incorporate the standard electrical and plumbing symbols, and be at a scale of 1/8” = 1’0” or larger. Materials and/or installation shall be explicitly noted and adequately specified to allow for performing Landlord review, securing a building permit, pursuing construction pricing, and performing construction. All equipment and installations shall be made in accordance with standard materials and procedures unless a deviation outside of industry standards is shown on the Construction Documents and approved by Landlord. To the extent practicable, a concise description of products, acceptable substitutes (if any), and installation procedures and standards shall be provided to the extent customary. Product cuts (where reasonably requested by Landlord) must be provided and special mechanical or electrical loads noted. Landlord’s approval of the plans, drawings, specifications or other submissions in respect of any work, addition, alteration or improvement to be undertaken by or on behalf of Tenant shall create no liability or responsibility on the part of Landlord for their completeness, design sufficiency or compliance with requirements of any applicable laws, rules or regulations of any governmental or quasi-governmental agency, board or authority.

3.Change Orders. The Construction Documents shall not be changed or modified by Tenant after approval by Landlord (except for Minor Variations thereto) without the further approval in writing by Landlord, which approval shall not be unreasonably withheld or delayed as provided in the Lease.

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Schedule B-3

Landlord’s Construction Plans

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Those certain Construction Documents entitled “645 Summer Street Core & Shell Upgrade For Akuous”, dated December 4, 2020, prepared by Jacobs.

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EXHIBIT C

LETTER OF CREDIT REQUIREMENTS

This Exhibit is attached to and made a part of the First Amendment to Lease (“First Amendment”) by and between OPG MP PARCEL OWNER (DE) LLC, a Delaware limited liability company (“Landlord”), and AKOUOS, INC., a Delaware corporation (“Tenant”), for space in the Building located at 645 Summer Street, Boston, MA 02210.  Capitalized terms used but not defined herein shall have the meanings given in the First Amendment.

The Expansion Premises Letter of Credit (as defined in the First Amendment) shall be for the amount set forth in Section 10 of the First Amendment.  The Expansion Premises Letter of Credit (i) shall be irrevocable and shall be issued by a commercial bank that has a financial condition reasonably acceptable to Landlord and has an office in Boston, Massachusetts or New York, New York that accepts requests for draws on the Expansion Premises Letter of Credit, (ii) shall require only the presentation to the issuer of a certificate of the holder of the Expansion Premises Letter of Credit stating that the Landlord is entitled to draw on the Expansion Premises Letter of Credit pursuant to the terms of the Lease and a draw request in the bank’s form together with the original letter of credit, (iii) shall be payable to Landlord and shall be freely transferable to a successor landlord or mortgage lender without cost to any such successor or any lender holding a collateral assignment of Landlord’s interest in the Lease, (iv) shall be for an initial term of not less than one year and contain a provision that such term shall be automatically renewed for successive one-year periods unless the issuer shall, at least thirty (30) days prior to the scheduled expiration date, give Landlord notice of such nonrenewal, and (v) shall otherwise be in form and substance reasonably acceptable to Landlord.  Notwithstanding the foregoing, the term of the Expansion Premises Letter of Credit for the final period shall be for a term ending not earlier than the date thirty (30) days after the last day of the Term.  In the event that the issuer ceases to be reasonably acceptable to Landlord, due to a deterioration in its financial condition or change in status that threatens to compromise Landlord’s ability to draw on the Expansion Premises Letter of Credit as determined in good faith by Landlord, then Tenant shall provide a replacement Letter of Credit from an issuer satisfying the terms of this Exhibit within thirty (30) days after Landlord’s notice of such event.

Landlord shall be entitled to draw upon the Expansion Premises Letter of Credit for its full amount or any portion thereof if (a) Tenant shall fail to perform any of its obligations under the Lease after the expiration of any applicable notice and cure period, or fail to perform any of its obligations under the Lease and transmittal of a default notice or the running of any cure period is barred or tolled by applicable law, or fail to perform any of its obligations under the Lease and any applicable notice and cure period would expire after the expiration of the Expansion Premises Letter of Credit, or (b) not less than thirty (30) days before the scheduled expiration of the Expansion Premises Letter of Credit, Tenant has not delivered to Landlord a new Letter of Credit in accordance with this Exhibit.  Without limiting the generality of the foregoing, Landlord may, but shall not be obligated to, draw on the Expansion Premises Letter of Credit from time to time in the event of a bankruptcy filing by or against Tenant and/or to compensate Landlord, in such order as Landlord may determine, for all or any part of any unpaid rent, any damages arising from any termination of the Lease in accordance with the terms of the Lease, and/or any damages arising from any rejection of the Lease in a bankruptcy proceeding commenced by or against

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Tenant.  Landlord may, but shall not be obligated to, apply the amount so drawn to the extent necessary to cure Tenant’s failure. 

Any amount of the Expansion Premises Letter of Credit drawn in excess of the amount applied by Landlord to cure any default (beyond applicable notice and cure periods) of Tenant shall be held by Landlord as a cash security deposit for the performance by Tenant of its obligations under the Lease.  Any cash security deposit may be mingled with other funds of Landlord and no fiduciary relationship shall be created with respect to such deposit, nor shall Landlord be liable to pay Tenant interest thereon.  If Tenant shall fail to perform any of its obligations under the Lease beyond any applicable notice and cure periods, Landlord may, but shall not be obliged to, apply the cash security deposit to the extent necessary to cure Tenant’s failure.  After any such application by Landlord of the Expansion Premises Letter of Credit or cash security deposit, as the case may be, Tenant shall reinstate the Expansion Premises Letter of Credit to the amount originally required to be maintained under the Lease, upon demand (and if any excess amounts were drawn by Landlord, Landlord shall immediately return such amounts to Tenant following Tenant’s reinstatement of the Expansion Premises Letter of Credit).  Within thirty (30) days after the later to occur of (i) the payment of the final Rent due from Tenant or (ii) the later to occur of the New Expiration Date or the date on which Tenant surrenders the Premises to Landlord in compliance with the terms of the Lease, the Expansion Premises Letter of Credit and any cash security deposit, to the extent not applied, shall be returned to the Tenant, without interest, less any amounts necessary to cure any outstanding Tenant defaults.

In the event of a sale of the Building or lease, conveyance or transfer of the Building, Landlord shall transfer the Expansion Premises Letter of Credit and any cash security deposit to the transferee.  Upon such transfer and assumption of Landlord’s obligations by the transferee, the transferring Landlord shall be released by Tenant from all liability for the return of such security, and Tenant agrees to look to the transferee solely for the return of said security.  The provisions hereof shall apply to every transfer or assignment made of the security to such a transferee.  Tenant further covenants that it will not assign or encumber or attempt to assign or encumber the Expansion Premises Letter of Credit or the monies deposited herein as security, and that neither Landlord nor its successors or assigns shall be bound by any assignment, encumbrance, attempted assignment or attempted encumbrance.

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EXHIBIT D

FORM OF NOTICE OF LEASE

This Exhibit is attached to and made a part of the First Amendment to Lease (“First Amendment”) by and between OPG MP PARCEL OWNER (DE) LLC, a Delaware limited liability company (“Landlord”), and AKOUOS, INC., a Delaware corporation (“Tenant”), for space in the Building located at 645 Summer Street, Boston, MA 02210.  Capitalized terms used but not defined herein shall have the meanings given in the First Amendment.

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[See Attached]

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notice of lease

Notice is hereby given, pursuant to the provisions of Chapter 183, Section 4 of the General Laws of Massachusetts, of the following lease (the “Lease”).

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DATE OF LEASE EXECUTION:  December 28, 2018, as amended by that certain First Amendment to Lease with a  date of execution of ___________, 2021 (the “First Amendment”).

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TENANT:  AKOUOS, INC., a Delaware corporation

description of DEMISED premises:    The demised Premises consists of approximately 75,000 rentable square feet in the aggregate, consisting of (i) the entire southern half of the second (2^nd) floor of the building located at 645 Summer Street, Boston, Massachusetts (the “Building”), containing approximately 37,500 rentable square feet (the “Existing Premises”) and (ii) the entire southern half of the first (1^st) floor of the Building, containing approximately 37,500 rentable square feet (the “Expansion Premises”).  The demised Premises are located on parcels of land more particularly described in an assignment of ground lease recorded with the Suffolk Registry of Deeds on October 3, 2019, in Book 61844, Page 194, and filed for registration with the Suffolk Registry District of Land Court on October 3, 2019 as Document No. 899129, Certificate of Title No. 77533.

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term OF LEASE:  The term of the Lease commenced on November 20, 2019 with respect to the Existing Premises, and will commence on the Expansion Premises Commencement Date with respect to the Expansion Premises, and shall continue until the last day of the one hundred twentieth (120^th) full calendar month following the Expansion Premises Rent Commencement Date (as defined in the First Amendment, and which shall occur no later than nine (9) months after the Expansion Premises Commencement Date as provided therein) with respect to both the Existing Premises and the Expansion Premises (the “New Expiration Date”), plus any exercised extension period, as described below.  

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EXPANSION PREMISES COMMENCEMENT DATE:  Expansion Premises Commencement Date shall mean the later of (i) April 1, 2021 and (ii) the date on which Landlord delivers the Expansion Premises in the condition required under the First Amendment.  

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RIGHT OF EXTENSION OR RENEWAL: Tenant has the right to extend the Term of the Lease beyond the New Expiration Date for one additional five (5) year period, in accordance with the First Amendment.  

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RIGHT OF FIRST OFFER:  Tenant has a “right of first offer” for Available Space, as such right is more particularly described in Section 2.3 of the Lease.

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OTHER PROVISIONS: The Lease contains additional rights, terms and conditions not enumerated in this instrument.  This instrument is executed pursuant to the provisions of the Lease and shall not vary or increase the rights, terms and conditions of the Lease, or create any new rights, terms or conditions.  Any inconsistency between the terms of the Lease and this instrument shall be resolved in favor of the Lease.  Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease.

[page ends here – signature page to follow]

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EXECUTED under seal as of the ___th day of _____________, 2021.

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EXHIBIT E

FORM OF SNDA

This Exhibit is attached to and made a part of the First Amendment to Lease (“First Amendment”) by and between OPG MP PARCEL OWNER (DE) LLC, a Delaware limited liability company (“Landlord”), and AKOUOS, INC., a Delaware corporation (“Tenant”), for space in the Building located at 645 Summer Street, Boston, MA 02210.  Capitalized terms used but not defined herein shall have the meanings given in the First Amendment.

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[See Attached]

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RECORDING REQUESTED BY
AND WHEN RECORDED MAIL TO:

Wilmer Cutler Pickering Hale and Dorr LLP
60 State Street
Boston, MA 02109
Attention: Benjamin R. Unger, Esq.

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SUBORDINATION, NON-DISTURBANCE
     AND ATTORNMENT AGREEMENT

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This SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT (this “Agreement”), dated as of the _____ day of ___________, 2021, between TD BANK, N.A., a national banking association, having an office at 200 State Street, 8^th Floor, Boston, Massachusetts 02110 (the “Lender”), and AKOUOS, INC., a Delaware corporation, with offices at 645 Summer Street, Boston, MA 02210 (the “Tenant”).

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R E C I T A L S:

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WHEREAS, Tenant has entered into a Lease, dated as of December 28, 2018 (the “Original Lease”), with Boston Harbor Industrial Development LLC, a Delaware limited liability company (the “Original Landlord”).  The Lease has been assigned to OPG MP Parcel Owner (DE) LLC, a Delaware limited liability company, as successor landlord (the “Landlord”).  Landlord and Tenant entered into that certain First Amendment to Lease dated as of January ____, 2021 (the “First Amendment”; the First Amendment together with the Original Lease, collectively the “Lease”), notice of the Lease is being recorded herewith.  The Lease covers certain premises more fully described in the Lease (the “Premises”), which Premises are a part of that the real property known 645 Summer Street, Boston, Massachusetts (the “Property”), which Property is more fully described on Schedule A attached hereto; and

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WHEREAS, Lender has made a mortgage loan (the “Mortgage Loan”) to Landlord, as borrower, which Mortgage Loan is evidenced by a Mortgage Note dated as of the 2^nd day of October, 2019 (the “Mortgage Note”), and is secured by a Leasehold Mortgage and Security Agreement (the “Mortgage”) and an Assignment of Leases and Rents (the “Assignment”), each of which is dated as of the 2^nd day of October, 2019.  The Mortgage is recorded with the Suffolk County Registry of Deeds in Book 61844, Page 199 and filed with the Suffolk Registry District of Land Court as Document No. 899130, Certificate of Title Nos. 77533 and 77534, encumbering the Property.  

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WHEREAS, Tenant desires to be able to obtain the advantages of the Lease and the occupancy thereunder in the event of foreclosure of the Mortgage and Lender wishes to have Tenant confirm the priority of the Mortgage over the Lease.  

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NOW, THEREFORE, in consideration of the mutual promises, covenants and agreements herein contained, the parties hereto, intending to be legally bound hereby, promise, covenant and agree as follows:

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4.Although the foregoing provisions of this Agreement shall be self-operative, Tenant agrees to execute and deliver to Lender or to any person to whom Tenant herein agrees to attorn, such other commercially reasonable instrument or instruments as Lender or such other person shall from time to time request in order to confirm such provision.

5.Tenant hereby warrants and represents, covenants and agrees to and with Lender:

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6.This Agreement shall inure to the benefit of and be binding upon the parties hereto and their successors and assigns.

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7. This Agreement shall be governed by and construed in accordance with the laws of the jurisdiction in which the Property is located.

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8.Tenant agrees that:

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9. Lender’s address for notices shall be:

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TD Bank, N.A.

200 State Street, 8th Floor

Boston, MA 02109

Attention: Steven Fessenden

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with a copy to:

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Nutter, McClennen & Fish, LLP

Seaport West

155 Seaport Boulevard

Boston, MA ###-###-####

Attention: Matthew J. Gaughan, Esq.

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Tenants address for notices shall be:

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Akouos, Inc.

645 Summer Street

Boston, MA 02210

Attention: Karoline K. Shair, Chief Legal Officer

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[NO FURTHER TEXT ON THIS PAGE]

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IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above written.

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LENDER:

TD BANK, N.A.

By: _________________________

Name:

Title:

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TENANT:

AKOUOS, INC.,

a Delaware corporation

By: _________________________

Name: Emmanuel Simons, PhD, MBA

Title: Chief Executive Officer

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By: _________________________

Name: Karoline K. Shair, PhD, JD

Title: Corporate Secretary

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Landlord:

OPG MP Parcel Owner (DE) LLC,

a Delaware limited liability company
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By: _________________________

Name:

Title:

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ACKNOWLEDGMENTS

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COMMONWEALTH OF MASSACHUSETTS)

) ss.:

COUNTY OF SUFFOLK)

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On this ___ day of __________, 2021, before me, the undersigned notary public, personally appeared __________________________, in his/her capacity as a ________________________ of TD Bank, N.A., and not individually, who proved to me through satisfactory evidence of identification, which was _________________________________, to be the person whose name is signed on the preceding or attached document and acknowledged to me that he/she signed it voluntarily for its stated purpose as a ________________________ of TD Bank, N.A.

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Notary Public

My commission expires:

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STATE/COMMONWEALTH OF ______________________)
) ss.:
COUNTY OF _______________________)

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On this ___ day of __________, 2021, before me, the undersigned notary public, personally appeared __________________________, in his/her capacity as a ________________________ of _________________________, and not individually, who proved to me through satisfactory evidence of identification, which was _________________________________, to be the person whose name is signed on the preceding or attached document and acknowledged to me that he/she signed it voluntarily for its stated purpose as a ________________________ of OPG MP Parcel Owner (DE) LLC.

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Notary Public

My commission expires:

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STATE/COMMONWEALTH OF ______________________)
) ss.:
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COUNTY OF _______________________)

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On this ___ day of __________, 2021, before me, the undersigned notary public, personally appeared Emmanuel Simons, in his/her capacity as the President of Akouos Inc., and not individually, who proved to me through satisfactory evidence of identification, which was _________________________________, to be the person whose name is signed on the preceding or attached document and acknowledged to me that he/she signed it voluntarily for its stated purpose as the President of Akouos, Inc., as the voluntary act of said corporation.

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Notary Public

My commission expires:

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STATE/COMMONWEALTH OF ______________________)
) ss.:
COUNTY OF _______________________)

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On this ___ day of __________, 2021, before me, the undersigned notary public, personally appeared Karoline K. Shair, in his/her capacity as the Corporate Secretary of Akouos, Inc., and not individually, who proved to me through satisfactory evidence of identification, which was _________________________________, to be the person whose name is signed on the preceding or attached document and acknowledged to me that he/she signed it voluntarily for its stated purpose as the Corporate Secretary of Akouos, Inc., as the voluntary act of said corporation.

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Notary Public

My commission expires:

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SCHEDULE A

Legal Description

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