Revised Letter of Payment Authorization

Exhibit 10.1

Revised Letter of Payment Authorization

June 17, 2008

Dr. Jay Lichter

Akesis Pharmaceuticals, Inc.

888 Prospect Street

Suite 320

La Jolla, CA 92037

E: ***@***

Dear Dr. Lichter,

We thank you for your interest in Charles River Laboratories and hope the attached proposal meets with your approval. For your convenience, we have provided the following summary of the titles and prices of the studies and/or study components under discussion. If you would like us to proceed with animal orders resource allocation, please initial the studies and components you wish to authorize at this time and sign and date the authorization line below. These prices are valid for 60 days, but may be modified by mutual agreement if changes to the scope of work are made.

In order to minimize the impact of study delays and cancellations for all sponsors, Charles River allocates resources at the time a signed Letter of Payment Authorization is received. Please note that scheduling is not considered confirmed until a signed copy of this document is received. By providing authorization via signature below, you will allow us to confirm a schedule for each authorized study. Your signature further constitutes acceptance of the price and payment schedule.

Price and Payment Schedule for Study LTC00013

The payment schedule and price of this study are as follows:

Price and Payment Schedule for Study LTC00014

The payment schedule and price of this study are as follows:

In the event Charles River does not receive comments pertaining to the draft report within 60 days after submission to the Sponsor, the final invoice will be due and payable.

We understand that occasionally you may request to delay or to cancel a study due to unforeseen circumstances. Charles River will make every reasonable effort to accommodate requested schedule changes. However, as significant costs are incurred related to study initiation, cancellation/delay fees will apply in proportion to the number of days’ notice given (please see attached Cancellation and Delay Policy). Cancellation/delay fees may be assessed separately for each postponement prior to the study being cancelled or initiated. The Cancellation and Delay Policy becomes effective upon execution of this Letter of Authorization.

Charles River shall perform these services in accordance with the Service Agreement (the “Agreement”) executed between Charles River Laboratories and Akesis Pharmaceuticals, Inc. Once fully executed, this Letter of Payment Authorization shall be incorporated into and made part of the Agreement.

REPEAT OF SAMPLE ANALYSIS. If applicable, the parties agree that as of commencement of work, in some instances, repeat of sample analysis will be required. If this arises, Charles River must notify the Sponsor as soon as possible and determine, between the parties, if these repeats are required by Sponsor. Consequently, the price per sample analysis/occasion will apply to any additional repeats requested by the Sponsor, as well as any samples above the analytical range, which require dilution. However, in the event that additional sample analysis/occasions are required, Charles River shall submit a written estimate to the Sponsor for the Sponsor’s written approval, and the Sponsor shall respond to Charles River within five (5) business days, or within the specified time period sanctioned by the Sponsor for receipt of such estimates. Once authorization is received, Charles River will endeavor, when possible, to proceed with current batches of sample analysis. Both parties acknowledge that Charles River will be reimbursed for any amount which relates to the repeats if the difference between the original result of the sample analysis and the repeat result of the sample analysis, is within a 30% range.

SHIPMENT OF TEST ARTICLES. Sponsor and Charles River agree that all costs associated with shipping test article to Charles River shall be the responsibility of the Sponsor. Charles River shall not be responsible for any direct or indirect damages sustained by the Sponsor resulting from any loss, destruction or damage to the test article(s).

In the event of a conflict between the terms set forth in this letter and the Master Service Agreement, the terms of the Master Service Agreement shall control, unless specifically agreed upon to the contrary in this letter.

Please sign and return this document via facsimile or email (contact information below). Should you have any questions or require any additional information, please do not hesitate to call me. We look forward to being of service.

Best Regards,
		/s/ Jay B. Lichter Ph.D.
		Authorized Sponsor Representative
		President and CEO
		Print (Name and Title)
Christina Fox		6/18/08
Account Manager Charles River Laboratories, Inc. Preclinical Services Phone:    ###-###-#### Fax:         ###-###-#### E-Mail: ***@***		Date

If a PO is required, please submit PO with Letter of Payment Authorization or fax to Corporate Finance at ###-###-####.

Modifications or alterations can be made to the study design to suit specific test article and client needs. Modifications may alter pricing and scheduling.

Modifications or alterations can be made to the study design to suit specific test article and client needs. Modifications may alter pricing and scheduling.

POSTPONEMENT/CANCELLATION POLICY

Upon receipt of the signed quote letter or correspondence from the Sponsor confirming formal authorization, Charles River Laboratories Preclinical Services, hereinafter referred to as (“Charles River”) will order or reserve animals and allocate other resources for the specified study.

If the study is initiated on the scheduled start date, the most current quoted price is valid (unless advised otherwise by any revised quote letter) and no postponement or cancellation charges are applicable.

There will be no charges if the study is rescheduled or cancelled as long as notice is provided to Charles River in advance of the defined period of time prior to the animal arrival date, as stipulated below:

Should any applicable fees be charged from the animal supplier before the above-mentioned timelines, these would be the responsibility of the Sponsor.

Postponement Terms:

Prior To and Following Animal arrival:

Notice of postponement of the study by the Sponsor for any study with a duration of 28 days or more, through no fault of Charles River, prior to or following Animal arrival, shall be charged to the Sponsor at a rate based on the calculation of the total value of the study divided by the total weeks of the study duration, including weeks of acclimation period. Should the study be less than 28 days, Sponsor shall be charged at a rate of $10,500 per week of delay (“Housing Fees”). If the delay exceeds more than four weeks, it would automatically be subject to the cancellation terms below.

In any cases, Housing Fees do not include any technical work such as surgical preparation or other scientific procedures required in order to maintain the integrity of the study, which will be at additional cost.

Cancellation Terms:

Cancellation of the study by the Sponsor, through no fault of Charles River, which falls within the defined period of time above, will be assessed as follows:

Cancellation Charges

If sponsor cancels study after animal arrival and before study start the following charges will apply:

50% of total study price plus animal costs plus husbandry ($10,500 room/week) until relocation of animals or disposal.

If the Sponsor requests postponement of a study start, we will make every effort to accommodate the requested change; however, due to resource constraints, Charles River may not be able to reschedule the study precisely as requested by the Sponsor. If the new schedule is not acceptable, the Sponsor may elect to cancel the study, in which case the applicable cancellation charge would apply.

In the event of postponement or cancellation of the study by the Sponsor, additional compensation may be requested for items procured specifically for the study (e.g., animal purchases¹, dedicated equipment, perishable or non-reusable supplies) and any non-recoverable expenses incurred by Charles River (e.g., equipment lease payments, subcontractor charges or consultant fees to which Charles is irrevocably committed).

In the event the Sponsor terminates an ongoing study (i.e. early termination following dosing initiation), the Sponsor will be responsible for all incurred costs, committed costs and lost opportunity charges.

Exceptions to the above terms may be made on a case-by-case basis at Charles River sole discretion, if the study cancellation or postponement has little or no financial impact on Charles River (e.g. if notice that the study is subsequently cancelled or postponed falls within the defined period of time above pre-study period but no resources have been expended or costs incurred in the preparation for the study, and the animals can be readily used in another study [or exchanged, in the case of postponement]).

In the event of a conflict between the terms set forth in this letter and the Master Service Agreement, the terms of the Master Service Agreement shall control, unless specifically agreed upon to the contrary in this letter.