Amendment to Master Research and Collaboration Agreement, dated as of February 5, 2020, by and among the Registrant, Celgene Corporation and Celgene RIVOT Ltd

        This Amendment to Master Research and Collaboration Agreement (this “Amendment”) is entered into as of February 5, 2020 (the “Amendment Date”), by and among Agios Pharmaceuticals, Inc., a Delaware corporation (“Agios”), on the one hand, and Celgene Corporation, a Delaware corporation (“Celgene Corp.”), with respect to all rights and obligations under the Master Collaboration Agreement (as defined below) in the United States, and Celgene RIVOT Ltd., a Bermuda entity (“Celgene RIVOT”), with respect to all rights and obligations under the Master Collaboration Agreement outside of the United States (Celgene RIVOT and Celgene Corp. together, “Celgene”), on the other hand. Capitalized terms used herein and not defined herein shall have the meanings ascribed to them in the Master Collaboration Agreement.

        WHEREAS, the Parties entered into that certain Master Research and Collaboration Agreement, dated as of May 17, 2016 (the “Master Collaboration Agreement”), pursuant to which Celgene obtained exclusive options to obtain certain rights to participate in the development and commercialization of Compounds and Products arising out of activities conducted pursuant to certain research and development programs under the Master Collaboration Agreement and to share profits and losses arising from the development and commercialization of such Compounds and Products on a worldwide basis; and

        WHEREAS, the Parties previously entered into a certain Appendix Substitution Agreement dated as of January 29, 2019, relating to the Master Collaboration Agreement;

        NOW THEREFORE, the Parties are entering into this Amendment to provide for (i) a modification to the notice period for extensions of the Research Term and (ii) an extension of the Option Exercise Window solely with respect to the [**], in each case as set forth below.

1. Amendment Relating to Research Term.

Section 2.1.2(a) of the Master Collaboration Agreement is hereby deleted and replaced in its entirety with the following:

“2.1.2(a) Initial Extension Right. Celgene may, at its election, extend the Research Term for up to two (2) one (1) year extension periods (each to run consecutively after the end of the then-current Research Term) by giving notice to Agios of its election (i) in the case of the first one (1) year extension period, by no later than [**] and (ii) in the case of the second one (1) year extension period, at least [**] prior to the expiration of the then-current Research Term, and (in each case (i) and (ii)) by paying the Research Term Extension Fee as set forth in Section 6.3.”

2. Amendment Relating to the Option Exercise Window with respect to the [**].

(a) Prior to the Amendment Date, Agios provided to Celgene an Option Data Package for the [**]. Celgene acknowledges receipt of such Option Data Package.

(b) The Option Exercise Window applicable to the [**] is hereby amended to continue through [**] and to expire at the end of such day.

3. Continued Effectiveness of Master Collaboration Agreement. As amended hereby, the Master Collaboration Agreement remains in full force and effect.