FIFTH AMENDMENT OF THE AERIE PHARMACEUTICALS, INC. 2005 STOCK OPTION PLAN

Exhibit 10.10

FIFTH AMENDMENT

OF THE AERIE PHARMACEUTICALS, INC.

2005 STOCK OPTION PLAN

THIS FIFTH AMENDMENT of the Aerie Pharmaceuticals, Inc. 2005 Stock Option Plan is dated as of September 16, 2013.

WHEREAS, the Board of Directors of Aerie Pharmaceuticals, Inc. (the “Company”) has adopted and the stockholders of the Company have approved the Aerie Pharmaceuticals, Inc. 2005 Stock Option Plan, as previously amended (collectively, the “Plan”); and

WHEREAS, the Board of Directors deems it to be in the best interest of the Company to amend the Plan as more particularly set forth below.

NOW, THEREFORE, the Plan shall be amended as follows:

Subject to adjustment as provided in Paragraph 9 below, the maximum number of shares of Stock which may be issued pursuant to Options and awards of restricted stock granted under the Plan shall be eighteen million, eight hundred eighty-one thousand, one hundred thirty-seven (18,881,137) shares.

IN WITNESS WHEREOF, the undersigned representative of the Company certifies that the foregoing Fifth Amendment of the Plan was duly adopted by the Board of Directors.