SECOND AMENDMENT OF THE AERIE PHARMACEUTICALS, INC. 2005 STOCK OPTION PLAN

Exhibit 10.7

SECOND AMENDMENT

OF THE AERIE PHARMACEUTICALS, INC.

2005 STOCK OPTION PLAN

THIS SECOND AMENDMENT of the Aerie Pharmaceuticals, Inc. 2005 Stock Option Plan is dated as of December 3, 2009.

WHEREAS, the Board of Directors of Aerie Pharmaceuticals, Inc. (the “Company”) has adopted and the stockholders of the Company have approved the Aerie Pharmaceuticals, Inc. 2005 Stock Option Plan, as previously amended by that certain First Amendment of Aerie Pharmaceuticals, Inc. 2005 Stock Option Plan (collectively, the “Plan”); and

WHEREAS, the Board of Directors deems it to be in the best interest of the Company to amend the Plan as more particularly set forth below.

NOW, THEREFORE, the Plan shall be amended as follows:

The first sentence of Paragraph 4 of the Plan shall be deleted in its entirety and the following substituted in lieu thereof:

Subject to adjustment as provided in Paragraph 9 below, the maximum number of shares of Stock which may be issued pursuant to Options granted under the Plan shall be Five Million, Three Hundred Thousand (5,300,000) shares.

IN WITNESS WHEREOF, the undersigned Secretary of the Company certifies that the foregoing Second Amendment to the Plan was duly adopted by the Board of Directors.