AMENDMENT #1 TO ETHICON-ADVANCED BIOHEALING SUPPLY AGREEMENT

Exhibit 10.25

CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

AMENDMENT #1 TO ETHICON-ADVANCED BIOHEALING SUPPLY AGREEMENT

The Ethicon-Advanced BioHealing Supply Agreement between Ethicon, Inc., a New Jersey corporation (acting by and through its Ethicon Products Worldwide Division) (“Ethicon”) and Advanced BioHealing, Inc. (the “Advanced BioHealing”) effective as of November 9, 2006, as amended, supplemented or modified from time to time (the “Agreement”), is hereby amended as provided below. All defined terms used but not defined in this amendment have the meaning given those terms in the Agreement.

The parties agree as follows:

1. Performance Rebate

Advanced BioHealing is entitled to a rebate of [***]% of its Net Purchases for calendar year 2008 if, in such year its Net Purchases exceeds $[***].

Advanced BioHealing is entitled to a rebate of [***]% of its Net Purchases for calendar year 2009 if, in such year its Net Purchases exceeds the [***].

For purposes of this Agreement, Net Purchases means the [***] of [***] Mesh [***] minus any [***] and excluding [***].

Ethicon shall pay Advanced BioHealing any rebate due for a given period no later than [***] days after the end of that period.

If the Agreement is terminated prior to its End Date for any reason, Advanced BioHealing shall earn no rebates on purchases during the period in which the Agreement was terminated.

The Company shall pay the Customer any Rebate due for a given period no later than [***] days after the end of that period.

2. Effect of Amendment. This amendment is effective as of 12/31/2008. Except as modified by this amendment, the Agreement remains in effect. This amendment is to be construed as part of the Agreement.

3. Date of Amendment. This amendment is dated as of the date this amendment is signed by the second of the two parties to sign this amendment (as indicated by the dates written under each party’s signature to this amendment). This amendment will be void unless Advanced BioHealing returns this amendment bearing its signature to Ethicon by 12/31/2008.

Confidential treatment has been requested with respect to the omitted portions.