COLLABORATION AND LICENSE AGREEMENT By and Between PHARMACIA & UPJOHN COMPANY And NASTECH PHARMACEUTICAL COMPANY, INC. TABLE OF CONTENTS

EXHIBIT 10.1

[*Confidential treatment has been requested as to certain portions of this document. Each such portion, which has been omitted herein and replaced with an asterisk [*], has been filed separately with the Securities and Exchange Commission.]

COLLABORATION AND LICENSE AGREEMENT

By and Between

PHARMACIA & UPJOHN COMPANY

And

NASTECH PHARMACEUTICAL COMPANY, INC.

TABLE OF CONTENTS

SCHEDULE A
SCHEDULE B
SCHEDULE 2.4
SCHEDULE 4.3
SCHEDULE 4.5
SCHEDULE 9.1
SCHEDULE 12.5

COLLABORATION AND LICENSE AGREEMENT

     This Collaboration and License Agreement dated the 1st day of February, 2002 (the “Execution Date”) is by and between Pharmacia & Upjohn Company, a corporation organized and existing under the laws of the State of Delaware and having a place of business at 100 Route 206 North, Peapack, New Jersey 07977 (“Pharmacia”), and Nastech Pharmaceutical Company, Inc., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 45 Adams Avenue, Hauppauge, New York 11788 (“Nastech”).

RECITALS

     WHEREAS, Nastech is currently developing a product containing the Compound (as defined below) for the treatment of sexual dysfunction;

     WHEREAS, Pharmacia and/or its Affiliates are engaged in the research, development, production and sale of a wide range of pharmaceutical products;

     WHEREAS, Nastech and Pharmacia wish to enter into a licensing and collaboration arrangement regarding the development and commercialization of the Collaboration Product in the Field (as defined below), all on the terms and conditions set forth herein.

     NOW, THEREFORE, Nastech and Pharmacia, intending to be legally bound, hereby agree as follows:

ARTICLE 1

INTERPRETATION

When used in this Agreement, each of the following terms shall have the meanings set forth in this Article I:

“Affiliate” means any corporation, company, partnership, joint venture and/or firm which controls, is controlled by, or is under common control with a specified person or entity. For purposes of this definition, “control” shall be presumed to exist if one of the following conditions is met: (a) in the case of corporate entities, direct or indirect ownership of at least fifty percent (50%) of the stock or shares having the right to vote for the election of directors, and (b) in the case of non-corporate entities, direct or indirect ownership of at least fifty percent (50%) of the equity interest with the power to direct the management and policies of such non-corporate entities.

“Business Day” means a day on which banking institutions in New York, New York are open for business.

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“Change of Control” means (a) a merger or consolidation of a Party which results in the voting securities of such Party outstanding immediately prior thereto ceasing to represent at least fifty percent (50%) of the combined voting power of the surviving entity immediately after such merger or consolidation, (b) a Third Party becoming, directly or indirectly, the beneficial owner of fifty percent (50%) or more of the combined voting power of the outstanding securities of a Party or otherwise designating more than fifty percent (50%) of a Party’s board of directors, or (c) the sale or other transfer of all or substantially all of a Party’s assets which relate to this Agreement to a Third Party.

“Collaboration Product” means a Licensed Product that is Developed and/or Commercialized in the Field pursuant to the terms of this Agreement.

“Commercialization” or “Commercialize” means any and all activities directed to marketing, promoting, distributing, offering for sale and selling a product, importing a product for sale, conducting Phase IIIB Studies and Phase IV Studies, manufacturing for commercial sale, and interacting with Regulatory Authorities regarding the foregoing. When used as a verb, “Commercialize” means to engage in Commercialization.

“Commercialization Committee” means the committee formed pursuant to Section 5.2.

“Commercially Reasonable and Diligent Efforts” means (a) such diligent and conscientious endeavors as, consistent with standards of good faith and reasonableness under the attendant circumstances, are appropriate to attempt to accomplish the stated result and (b) with respect to the research, development, manufacture, regulatory approval, commercialization and other exploitation of the Collaboration Product, such efforts and resources as are commonly used in the pharmaceutical industry for an ethical drug of similar commercial potential at a similar stage in its lifecycle, taking into consideration its safety and efficacy, its cost to develop, the competitiveness of alternative products, its proprietary position, the likelihood of regulatory approval, its profitability and all other relevant factors. Commercially Reasonable and Diligent Efforts shall be determined on a market-by-market basis for each Collaborative Product, as applicable.

“Competitive Product” means any prescription pharmaceutical product, other than a Collaboration Product, which is delivered intranasally and is being Developed or Commercialized at any time following the Effective Date for the treatment of male erectile dysfunction (or if a Collaboration Product receives Regulatory Approval for the treatment of female sexual dysfunction, then for the treatment of female sexual dysfunction).

“Competitive PDE V Product” means any prescription pharmaceutical product that is determined to be an inhibitor of the human PDE-V enzyme subtype [*] compared to any other human receptor, enzyme or ion channel subtype. The Parties shall mutually agree upon the

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appropriate assay protocols for purposes of determining whether a particular compound is a Competitive PDE V Product.

“Compound” means apomorphine, including, without limitation, its salts, esters, metabolites, derivatives, isomers, hydrates, solvates, polymorphs and prodrugs thereof.

“Compulsory License” means a compulsory license under Nastech Technology obtained by a Third Party through the order, decree, or grant of a competent governmental authority or court, authorizing such Third Party to develop, make, have made, use, sell, offer to sell or import Collaboration Product in the Territory or in any portion thereof.

“Confidential Information” means all proprietary materials, know-how or other information (whether or not patentable) regarding a Party’s technology, products, business information or objectives relating to Licensed Product. Disclosures of Confidential Information may be made by written, graphic, oral, electronic or in any other form. The terms of this Agreement shall be considered Confidential Information of each Party.

“Control” or “Controlled” means with respect to any (a) material, item of information, method, data or other know-how, or (b) intellectual property right, in each case the possession (whether by ownership or license, other than pursuant to this Agreement) by a Party or its Affiliates of the ability to grant to the other Party access and/or a license as provided herein under such item or right without violating the terms of any agreement or other arrangement with any Third Party existing before or after the Execution Date.

“Development” or “Develop” means, preclinical and clinical drug development activities, including, among other things: test method development and stability testing, toxicology, formulation, process development, manufacturing scale-up, development-stage manufacturing, quality assurance/quality control development, statistical analysis and report writing, conducting clinical trials for the purpose of obtaining Regulatory Approval, product approval and registration, and regulatory affairs related to the foregoing. When used as a verb, “Develop” means to engage in Development. For clarity, Development does not include Phase IIIB Studies or Phase IV Studies.

“Development Oversight Committee” means the committee formed pursuant to Section 3.1.

“Development Cost” means all costs and expenses incurred in connection with all studies or activities performed following the Effective Date in accordance with the Global Development Plan for the Development of a Collaboration Product in the Field, including without limitation the cost of Collaboration Product for use in pre-clinical and clinical studies.

“Effective Date” means the HSR Clearance Date (as defined in Article 16) or, if the Parties mutually agree that an HSR Filing is not required, the date of such mutual written agreement.

“Execution Date” shall have the meaning set forth in the introduction paragraph of this Agreement.

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“FDA” means the United States Food and Drug Administration, or a successor agency thereto.

“Field” means the prevention, treatment, diagnosis or control of sexual dysfunction in humans, including, but not limited to, male erectile dysfunction and female sexual dysfunction.

“First Commercial Sale” means the first shipment of commercial quantities of the first Collaboration Product sold on arm’s length terms to a Third Party by Pharmacia or its Sublicensees in any country in the Territory after Regulatory Approval has been obtained for such Collaboration Product in such country. Sales for test marketing, sampling and promotional uses, clinical trial purposes or compassionate or similar use shall not be considered to constitute a First Commercial Sale.

“Fully Allocated Manufacturing Cost” or “FAMC” shall have the meaning provided such term in the Supply Agreement.

“GAAP” means the then current United States generally accepted accounting principles, consistently applied. All financial determinations made under this Agreement shall be made in accordance with GAAP.

“Global Commercialization Plan” means the plan and budget for the Commercialization of the Collaboration Product in the Field to be prepared pursuant to Section 5.6.

“Global Development Plan” means the plan for the Development of Collaboration Product to be prepared pursuant to Section 4.3.

“IND” means (a) (i) an Investigational New Drug Application, as defined in the U.S. Federal Food, Drug, and Cosmetic Act, as amended from time to time, and the regulations promulgated thereunder, that is required to be filed with the FDA before beginning clinical testing of a Collaboration Product in human subjects, or any successor application or procedure and (ii) any counterpart of a U.S. Investigational New Drug Application in any other country in the Territory, and (b) all supplements and amendments that may be filed with respect to the foregoing.

“Joint Know-How” means confidential information and materials, including, but not limited to, (i) pharmaceutical and chemical products, (ii) technical and non-technical data, and information relating to the results of tests, assays, methods and/or processes, and (iii) drawings, plans, diagrams, specifications and/or other documents containing said information and data, in each case which is made jointly by employees, consultants or agents of Nastech or its Affiliates and by employees, consultants or agents of Pharmacia or its Affiliates following the Execution Date and in the course of Development or Commercialization of Collaboration Product, but excluding the Joint Patents.

“Joint Patents” means all Patent Rights that claim Program Inventions and name as inventors one or more employees, consultants or agents of Nastech or its Affiliates together with one or more employees, consultants or agents of Pharmacia or its Affiliates.

“Joint Technology” means Joint Know-How and Joint Patents.

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“Laws” means all laws, statutes, rules, regulations, ordinances and other pronouncements having the effect of law or similar binding effect of any federal, national, multinational, state, provincial, county, city or other political subdivision, domestic or foreign.

“Licensed Product” means any product that contains the Compound delivered intranasally.

“Licenses” has the meaning provided such term in Section 2.1 hereof.

“Nastech Development Activities” means all of Nastech’s Development activities required to manufacture Collaboration Product, including without limitation test method development and stability testing, formulation, process development, manufacturing scale-up, development stage manufacturing, and quality assurance/quality control development, in each case in accordance with the Global Development Plan.

“Nastech Know-How” means confidential information and materials, which is Controlled by Nastech or its Affiliates, whether as of or after the Execution Date, to the extent such is useful or necessary for the manufacture, testing, use or sale in the Field of a Licensed Product or any component thereof, including, but not limited to, (i) pharmaceutical or chemical products, (ii) technical and non-technical data, and information relating to the results of tests, assays, methods and/or processes, and (iii) drawings, plans, diagrams, specifications and/or other documents containing said information and data. The Nastech Know-How shall include the Joint Know-How to the extent Controlled by Nastech.

“Nastech Owned Patents” means all Patent Rights, which are Controlled by Nastech or its Affiliates, whether as of or after the Execution Date, and which contain claims which would be infringed by the manufacture, use or sale of Licensed Product, or any component thereof, in the Field, in the absence of this Agreement. The Nastech Owned Patents as of the Execution Date are listed in Schedule A.

“Nastech Patents” means the Nastech Owned Patents and the Joint Patents to the extent Controlled by Nastech.

“Nastech Technology” means all Nastech Patents and Nastech Know-How.

“NDA” means (a) the single application or set of applications for approval and/or pre-market approval to make and sell commercially a pharmaceutical therapeutic product or delivery systems or device filed with the FDA, including all information included in drug master files related to such application(s), and any related registrations with or notifications to the FDA, and (b) any counterparts to such applications filed with any other national or supranational Regulatory Authority in the Territory.

“Net Sales” means, with respect to any Collaboration Product, the gross invoiced sales in the Territory of such Collaboration Product by Pharmacia and its Sublicensees beginning on the First Commercial Sale of such Collaboration Product, less the following deductions to the extent included in the gross invoiced sales or otherwise paid or incurred by Pharmacia or its Sublicensees:

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Use of Collaboration Product for promotional or sampling purposes and in clinical trials contemplated under this Agreement shall not be considered in determining Net Sales.

“Party” means Pharmacia or Nastech; “Parties” means Pharmacia and Nastech.

“Patent Rights” means all existing patents and patent applications and all patent applications hereafter filed, including any continuations, continuations-in-part, divisions, provisionals or any substitute applications, any patent issued with respect to any such patent applications, any reissue, reexamination, renewal or extension (including any supplementary protection certificate) of any such patent, and any confirmation patent or registration patent or patent of addition based on any such patent, and all foreign counterparts of any of the foregoing.

“Pharmacia Know-How” means confidential information and materials, which is Controlled by Pharmacia or its Affiliates, whether as of or after the Execution Date, to the extent such is useful or necessary for the manufacture, testing, use or sale of a Collaboration Product in the Field, or any component thereof, including but not limited to (i) pharmaceutical or chemical products, (ii) technical and non-technical data, and information relating to the results of tests, assays, methods and/or processes, and (iii) drawings, plans, diagrams, specifications and/or other documents containing said information and data. The Pharmacia Know-How shall include the Joint Know-How to the extent Controlled by Pharmacia.

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“Pharmacia Patents” means all Patent Rights which are Controlled by Pharmacia or its Affiliates as of or after the Execution Date and which contain claims which would be infringed by the manufacture, use or sale of Collaboration Product, or any component thereof, in the Field in the absence of this Agreement. Unless the context otherwise requires, Pharmacia Patents shall include the Joint Patents to the extent Controlled by Pharmacia.

“Pharmacia Technology” means the Pharmacia Know-How and the Pharmacia Patents.

“Phase IIIB Study” means a clinical trial intended to enhance the commercial profile of a product for a non-approved indication and not required or pivotal for Regulatory Approval for the initial indication.

“Phase IV Study” means clinical, preclinical, epidemiological modeling, and pharmacoeconomic studies that are designed to support marketing, publications, or future labeling changes within an approved indication.

“Program Invention” means all patentable inventions and discoveries that are conceived or reduced to practice by one or more employees, agents or consultants of Nastech and/or one or more employees, agents or consultants of Pharmacia under this Agreement in the course of performing the Development of a Collaboration Product.

“Promotional Expenditures” means all direct promotion and sales force costs and expenses incurred by Pharmacia in the Commercialization of Collaboration Product in the Territory. Promotional Expenditures include, without limitation, all costs related to (a) advertising, promotion, medical education and Collaboration Product publicity, (b) dissemination of scientific information to the healthcare community, (c) professional education services, (d) samples and field aids used in connection with Collaboration Product marketing and promotion, (e) clinical experience programs and market research activities, such as economic modeling, focus groups, studies and monitoring of market penetration and market share, (f) the costs of any Pharmacia sales forces utilized in the marketing and promotion of a Collaboration Product, as such costs are determined based on methodologies utilized by Pharmacia across all of its other products, (g) payments made to any Third Party for any Third Party sales forces utilized in the marketing and promotion of a Collaboration Product, (h) direct consumer advertising, (i) clinical trials conducted outside of the registration program for a particular indication (e.g., Phase IIIb and Phase IV clinical trials), and (j) training materials.

“Regulatory Approval” means any and all approvals, licenses, registrations, or authorizations of any federal, national, multinational, state, provincial or local regulatory agency, department, bureau or other governmental entity necessary for the manufacture, use, storage, import, export, transport, promotion, marketing and sale of a product in a country, together with any governmental price or reimbursement approvals.

“Regulatory Authority” means any governmental regulatory authority involved in granting Regulatory Approvals of any Collaboration Product, including, without limitation, the FDA and the European Commission.

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“Stock Exchange” means the New York Stock Exchange or any similar exchange upon which the securities of a Party or any of its Affiliates are traded.

“Sublicensee” means a Third Party, which has been granted sublicense rights pursuant to this Agreement, which rights include at least the rights to make and sell Collaboration Product. Third Parties that are permitted only to distribute and resell Finished Product or that manufacture or finish Collaboration Product for supply to Pharmacia or its Affiliates are not “Sublicensees.”

“Supply Agreement shall have the meaning provided such term in Section 6.5 hereof.

“Territory” means all the countries of the world.

“Third Party” means any person or entity other than a Party or any of its Affiliates.

“Third Party License Agreement” means any license or sublicense agreement between Nastech or its Affiliates and a Third Party relating to Nastech Technology existing before or after the Execution Date.

“TPP” means the target product profile of the Collaboration Product for the male erectile dysfunction indication as set forth in Schedule B hereto, as it may be amended from time to time by written agreement of the Parties.

“Triggering Event” means a Change in Control with respect to Pharmacia involving a Third Party which is actively Developing or Commercializing a Triggering Product as of the effective date of such Change in Control; provided, however, that in the case of a Triggering Product that is a Competitive PDE V Product and which is not yet being Commercialized as of the effective date of such Change in Control, such product is then at a more advanced stage of Development than the first Collaboration Product being Developed pursuant to this Agreement.

“Triggering Product” means (i) any Competitive Product, or any (ii) Competitive PDE V Product that is being Developed or Commercialized for the treatment of male erectile dysfunction (or if a Collaboration Product receives Regulatory Approval for the treatment of female sexual dysfunction, then for the treatment of female sexual dysfunction).“Unit” shall have the meaning provided such term in the Supply Agreement.

“Unit” shall have the meaning provided such term in the Supply Agreement.

“Valid Claim” means a claim of any issued, unexpired Patent Right which has not been revoked or held unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction from which no appeal can be taken, or with respect to which an appeal is not taken within the time allowed for appeal, and which has not been disclaimed, denied or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise.

Additional Definitions. Each of the following definitions is set forth in the section of this Agreement indicated below:

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Additional Definitions. Each of the following definitions is set forth in the section of this Agreement indicated below:

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ARTICLE 2

SCOPE OF RELATIONSHIP AND GRANT OF RIGHTS

     2.1) Scope of Relationship and Grant of Rights. Nastech hereby grants to Pharmacia an exclusive right and license under the Nastech Technology to Develop, make, have made, use, offer for sale, sell and import Licensed Product for use in the Field in the Territory, subject to the terms and conditions in this Agreement(the “Licenses”). The Licenses shall be effective as of the Effective Date and shall remain in effect on a country-by-country basis during the Term applicable thereto, as set forth in Section 12.1 hereof.

     2.2) Sublicense Rights. Pharmacia may grant sublicenses to its Affiliates and Third Parties under the Licenses; provided, however, Pharmacia may not grant any sublicense to a Third Party with respect to the United States, Japan, Germany, France, United Kingdom, Spain or Italy without the prior written consent of Nastech, such consent not to be unreasonably withheld or delayed.

     2.3) Nastech Reserved Rights. Notwithstanding the rights granted under Section 2.1, and in furtherance and not limitation of the provisions of Section 10.9, Nastech reserves the rights under the Nastech Technology (a) to make, have made, use, import and sell to Pharmacia active pharmaceutical ingredient of Collaboration Product and the Finished Products as set forth in this Agreement, (b) subject to Section 2.4, to research and Develop, make, have made, use, offer for sale, sell and import Licensed Product solely for use outside the Field, and (c) subject to Sections 2.4 and 2.5, to grant licenses to Third Parties under Sections 2.3(a) and 2.3(b).

     2.4) Development and Commercialization Outside the Field.

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     2.5) ROFN Outside Field. If Nastech intends to grant any rights or licenses to one or more Third Parties during the Term for the Development or Commercialization of any Licensed Product for an indication outside the Field, then the following provisions shall apply.

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     2.6) Certain Covenants of Nastech. Nastech covenants to Pharmacia that commencing on the Effective Date and until the expiration of the Term neither it nor any of its Affiliates or licensees will (A) conduct, cause any Third Party to conduct, or permit any licensee of Nastech to conduct, a human clinical trial within the Field with respect to any Licensed Product, (B) publish or permit any licensee to publish any data from any human clinical trial which would promote a Licensed Product for use in the Field or otherwise promote a Licensed Product for use in the Field through publications, symposia, advertising or the like, or (C) knowingly furnish a Licensed Product or Compound to any Third Party for any such purpose. As of the Execution Date, Nastech represents that neither it nor any of its Affiliates has authorized any licensees to conduct any of the aforementioned activities. Nastech covenants that following the Effective Date, Nastech and its Affiliates will include a covenant regarding all of the foregoing in any agreement with any Third Party licensing any of Nastech’s or its Affiliates’ rights to a Licensed Product or the use of any Nastech Technology outside the Field, and such license agreement shall expressly provide that Pharmacia shall be a third party beneficiary of such covenant.

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     2.7) Certain Covenants of Pharmacia. Pharmacia covenants to Nastech that commencing on the Effective Date and until the expiration of the Term that neither it nor any of its Affiliates or Sublicensees (A) will Develop, market, promote or sell a Licensed Product in the Field in the Territory except as a Collaboration Product pursuant to this Agreement, (B) conduct, cause any Third Party to conduct, or permit any Sublicensee to conduct, a human clinical trial outside the Field with respect to any Licensed Product, (C) publish or permit any Sublicensee to publish any data from any human clinical trial which would promote a Licensed Product for use outside the Field or otherwise promote a Licensed Product for use outside the Field through publications, symposia, advertising or the like, or (D) knowingly furnish a Licensed Product or Compound to any Third Party for any such purpose. Pharmacia covenants that following the Effective Date and until the expiration of the Term, Pharmacia will include a covenant regarding all of the foregoing in any license agreement with any Third Party regarding a Licensed Product or the use of any Nastech Technology in the Field, and such agreement shall expressly provide that Nastech shall be a third party beneficiary of such covenant.

     2.8) Section 365(n) of the Bankruptcy Code. All rights and licenses granted under or pursuant to any section of this Agreement are, and shall otherwise be deemed to be, for purposes of Section 365(n) of the Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101(35A) of the Bankruptcy Code. Each Party shall retain and may fully exercise all of its rights and elections under the Bankruptcy Code or equivalent legislation in any other jurisdiction. Upon the bankruptcy of either Party, the other Party shall further be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property, and such, if not already in its possession, shall be promptly delivered to such other Party, unless the Party in bankruptcy elects to continue, and continues, to perform all of its obligations under this Agreement.

     2.9) Nastech’s Right to Use Certain Pharmacia Data Outside the Field. Subject to the provisions of Sections 2.4, 2.5 and 2.6, Pharmacia grants Nastech the right to utilize any data developed by Pharmacia in the course of the Development of a Collaboration Product for the sole purpose of enabling Nastech to Develop Licensed Product for use outside the Field.

     2.10) Pharmacia’s Right to Use Certain Nastech Data in the Field. Subject to the provisions of Section 2.7, Nastech grants Pharmacia the right to utilize any data developed by Nastech in the course of the Development of a Licensed Product outside the Field for the sole purpose of enabling Pharmacia to Develop Collaboration Product for use in the Field.

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ARTICLE 3

DEVELOPMENT OVERSIGHT COMMITTEE

     3.1) Development Oversight Committee.

     3.2) Development Oversight Committee Responsibilities. The Development Oversight Committee shall be responsible for:

     3.3) Decision Making; Administrative Matters.

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ARTICLE 4

DEVELOPMENT OF LICENSED PRODUCTS

     4.1) Cooperation Regarding Development. Each Party shall reasonably cooperate with the other in order to enable the other Party to discharge its obligations and exercise its rights under this Agreement. Nastech shall use Commercially Reasonable and Diligent Efforts to complete its obligations under this Agreement, including without limitation provision of Nastech

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Know-How to Pharmacia, and its manufacture and supply of Collaboration Product. Pharmacia shall use Commercially Reasonable and Diligent Efforts to complete the Development of Collaboration Product, and file for and obtain Regulatory Approvals for and bring to market Collaboration Product for use in the Field in the US, Japan and major EU markets, all in accordance with its responsibilities as set out in the Global Development Plan adopted pursuant to Section 4.3.

     4.2) Development Responsibilities. Subject to the general oversight of the Development Oversight Committee and the provisions of Section 4.5, Pharmacia shall be responsible for performing all Development of Collaboration Product following the Effective Date that is required in order to obtain Regulatory Approval for Collaboration Product in the Field, except Nastech shall be responsible for the Nastech Development Activities. Pharmacia shall perform all of its Development activities in accordance with the INDs for the Collaboration Product and the Global Development Plan. Without limiting the generality of the foregoing, Pharmacia shall be responsible for:

     4.3) Global Development Plan. All Development of Collaboration Product shall be conducted by Pharmacia in accordance with the Global Development Plan, as it may be amended by the Development Oversight Committee from time to time. Attached hereto as Schedule 4.3 is a preliminary outline of the initial Global Development Plan, which provides a non-binding outline of the major Development activities currently expected to be undertaken until filing of the NDA. It is understood that such outline is preliminary in nature and subject to additional Pharmacia review and management approval. The Global Development Plan shall be updated on a regular basis, no less often than annually.

     4.4) Development Activities.

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     4.5) Development Costs. Commencing on the Effective Data, Pharmacia shall be responsible for all Development Costs in the Field; provided, however, Nastech shall be responsible for all Development Costs incurred prior to the Execution Date. For any pre-clinical or clinical study initiated prior to the Execution Date and set forth on Schedule 4.5, (a) all costs of such study incurred after the Effective Date shall be paid by Pharmacia, and (b) within thirty days following the Effective Date, Pharmacia shall reimburse Nastech for any Development Costs incurred with respect to such study following the Execution Date and prior to the Effective Date to the extent such costs are set forth on Schedule 4.5.

     4.6) Reimbursement of Development Costs. After the Development Oversight Committee has approved a budget for Nastech Development Activities and such budget is set forth in a Global Development Plan, Nastech may incur costs in connection with its performance of such budgeted Nastech Development Activities. Within forty-five (45) days after each calendar quarter, Nastech shall submit to Pharmacia a written report setting forth in reasonable detail its costs incurred in the performance of Nastech Development Activities in such calendar quarter. Pharmacia shall reimburse Nastech for such costs within forty five (45) days after its receipt of the written report; provided, however, Pharmacia shall have no obligation to reimburse costs with respect to a particular Nastech Development Activity to the extent the actual costs exceeded the budgeted costs.

ARTICLE 5

COMMERCIALIZATION OF LICENSED PRODUCTS

     5.1) Responsibility for Commercialization of Collaboration Product. Pharmacia will be solely responsible for all Commercialization of Collaboration Product in the Territory,

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subject to the oversight of the Commercialization Committee. Pharmacia shall use Commercially Reasonable and Diligent Efforts to Commercialize at least one Collaboration Product in the US, Japan and major EU markets.

     5.2) Commercialization Committee.

     5.3) Commercialization Committee Responsibilities. To the extent permitted by applicable Law, the Commercialization Committee will facilitate the Commercialization of Collaboration Product on a global basis, including, among other things:

     5.4) Decision Making. All decisions of the Commercialization Committee shall be made by the unanimous decision of Nastech and Pharmacia (subject to Section

     5.5) Dispute Resolution. If the Commercialization Committee is unable to reach unanimous agreement on any issue within its purview relating to the Commercialization of Collaboration Product, such issue shall be determined by Pharmacia.

     5.6) Global Commercialization Plan. On an annual basis, the Commercialization Committee shall approve a Global Commercialization Plan, which outlines the overall strategy and plan for the Commercialization of each Collaboration Product. Pharmacia shall prepare and submit to the Commercialization Committee for its review and approval each such Global Commercialization Plan. The Global Commercialization Plan shall be updated as deemed necessary but at least annually by Pharmacia.

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     5.7) Detailing.

     5.8) Promotional Expenditures. Pharmacia shall be responsible for all expenses related to Commercialization of Collaboration Product in the Field in the Territory. During the period [*], Pharmacia shall incur Promotional Expenditures of at least [*]. During the [*], Pharmacia shall incur Promotional Expenditures of [*] of the corresponding year’s projected annual Net Sales based on forecasts contained in the Global Commercialization Plan for Collaboration Product. During the [*], Pharmacia shall incur Promotional Expenditures of [*] of the corresponding year’s projected annual Net Sales based on forecasts contained in the Global Commercialization Plan for Collaboration Product.

     5.9) Orders; Recognizing Sales. Pharmacia shall be responsible for distributing Collaboration Product, accepting and fulfilling sales orders for Collaboration Product and recognizing sales of Collaboration Product. Nastech is not authorized to accept sales orders for Collaboration Product. If, for any reason, Nastech should receive sales orders for a Collaboration Product, Nastech shall forward such orders to Pharmacia as soon as practicable.

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ARTICLE 6

MANUFACTURE AND SUPPLY

     6.1) Responsibility for Development Supply. During the term of the Supply Agreement, Nastech shall be responsible for manufacturing all quantities of Collaboration Product and Placebo (as such term is defined in the Supply Agreement) necessary for Development throughout the Territory. Following the expiration of the term of the Supply Agreement, Pharmacia shall be responsible for manufacturing all quantities of Collaboration Product and Placebo (as such term is defined in the Supply Agreement) necessary for Development throughout the Territory. As part of Nastech’s responsibilities pursuant to this Section 6.1, it shall be responsible for all aspects of its supply chain (including both active pharmaceutical ingredient and Collaboration Product), quality control, quality assurance, release testing, and packaging. Nastech shall supply the required quantities of Collaboration Product and Placebo for the Development of such Collaboration Product to Pharmacia at the prices and the other terms set forth in the Supply Agreement.

     6.2) Responsibility for Commercial Supply of API. If requested by Pharmacia, Nastech shall use Commercially Reasonable and Diligent Efforts to (i) assist Pharmacia in securing a qualified Third Party manufacturing source for the active pharmaceutical ingredient of Collaboration Product, and (ii) following the expiration or termination of the Supply Agreement (including any extension of the term thereof), assign to Pharmacia any of its then existing supply agreements with Third Party manufacturers of the active pharmaceutical ingredient of Collaboration Product.

     6.3) Responsibility for Commercial Supply of Finished Product. The Parties acknowledge that the annual manufacturing capacity of Nastech’s facility is [*] and, in order to secure the supply of the first Collaboration Product for Commercialization, Pharmacia shall, prior to the First Commercial Sale, qualify its or a Third Party’s manufacturing facility for the manufacture of the first Collaboration Product for Commercialization. Thereafter, Pharmacia shall also qualify its or a Third Party’s manufacturing facility for the manufacture of any additional Collaboration Products. During the period between the Effective Date and the fifth (5th) anniversary of the First Commercial Sale, and subject to the provisions of Section 6.4 and the Supply Agreement, Nastech shall be responsible for manufacturing in each calendar year of the lesser of (i) all quantities of Collaboration Product necessary for Commercialization throughout the Territory, and (ii) [*], all in accordance with the terms of the Supply Agreement. During such period, Pharmacia shall be responsible for manufacturing any quantities of Collaboration Product necessary for Commercialization of Collaboration Product throughout the Territory in excess of the quantities for which Nastech is responsible pursuant to the immediately preceding sentence. In addition, the Parties shall be jointly responsible for, and shall collaborate

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with each other regarding, process development and scale up of the manufacturing process of any Collaboration Product that Nastech will supply to Pharmacia pursuant to the Supply Agreement, with each Party bearing all of the costs incurred by it in performing such activities. In the event Nastech is unable to supply the required quantities of Collaboration Product set forth in this Section 6.3, Pharmacia may manufacture that amount of Collaboration Product required for Commercialization but Nastech is unable to supply. Following the expiration or termination of the Supply Agreement (including any extension of the term thereof), Pharmacia shall be responsible for manufacturing all quantities of Collaboration Product necessary for Commercialization throughout the Territory; provided, however, if the term of the Supply Agreement is extended, Nastech shall be responsible for manufacturing, and Pharmacia shall be responsible for purchasing from Nastech, Collaboration Product during the period of such extension in accordance with the terms of the Supply Agreement.

     6.4) Pharmacia’s Right to Manufacture Finished Product. During the first five (5) years after the First Commercial Sale, Pharmacia may elect, in its sole discretion, to manufacture or have manufactured up to [*] of the active pharmaceutical ingredient and Collaboration Product required for Commercialization in the Territory by providing a written notice to Nastech no later than one hundred eighty (180) days prior to the commencement of such manufacturing by Pharmacia. In the event Pharmacia elects to so manufacture, in addition to the sales based compensation under Article 9, Pharmacia shall pay to Nastech a royalty equal to [*] of Net Sales on the quantities of Collaboration Product manufactured and sold by Pharmacia during the first five (5) years after the First Commercial Sale; provided, however, such royalties shall not be due with respect to any quantities of Collaboration Product manufactured by Pharmacia (i) as a result of Nastech’s failure to supply pursuant to the Supply Agreement (unless such failure is caused primarily by any act or omission of Pharmacia or its Sublicensees in breach hereof or of the Supply Agreement) or (ii) which are in excess of [*] per calendar year. For avoidance of doubt, no royalties shall be due to Nastech under this Section 6.4 with respect to Pharmacia’s manufacture of Collaboration Product following the first five (5) years after the First Commercial Sale (whether or not the term of the Supply Agreement is extended by the Parties).

     6.5) Manufacturing Terms. Subject to Pharmacia’s reimbursement of costs incurred for Nastech Development Activities under Section 4.6, each Party shall incur all costs to establish such Party or a Third Party acting on its behalf as a manufacturer of the active pharmaceutical ingredient and Collaboration Product. Contemporaneously with the execution of this Agreement, Nastech and Pharmacia are entering into a supply agreement, effective as of the Effective Date, setting forth the terms under which Nastech will supply Collaboration Product, and any Collaboration Product for use as samples to Pharmacia (the “Supply Agreement”). Subject to the provisions of Section 9.11, Nastech shall deliver the Collaboration Product and samples to Pharmacia at the prices set forth in the Supply Agreement. If there is any inconsistency with the terms of this Article 6 and the terms of the Supply Agreement, the terms of the Supply Agreement shall govern.

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ARTICLE 7

REGULATORY MATTERS

     7.1) Ownership. Following the Effective Date, Nastech shall transfer to Pharmacia all existing INDs regarding Collaboration Product. All further submissions under such INDs, and any additional INDs regarding Collaboration Product for use in the Field, shall be filed in the name of and owned by Pharmacia. Pharmacia shall hold all Regulatory Approvals for Collaboration Product throughout the Territory. Pharmacia shall allow Nastech to reference relevant portions of the INDs and NDAs for Collaboration Product to the extent allowed under applicable Laws and necessary to enable Nastech to file and pursue Licensed Product for use solely outside the Field, and subject to the provisions of Section 2.4. Nastech shall allow Pharmacia to reference relevant portions of Nastech’s INDs and NDAs for Licensed Product being developed for use outside the Field to the extent allowed under applicable Laws and necessary to enable Pharmacia to file and pursue Collaboration Product for use solely in the Field, and subject to the provisions of Section 2.7.

     7.2) Regulatory Coordination.

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     7.3) Pharmacovigilance. In the event that Nastech initiates clinical Development of a Licensed Product for use outside the Field in accordance with terms of this Agreement, then the pharmacovigilance departments of both Parties shall meet and determine the approach to be taken for the collection, review, assessment, tracking and filing of information related to adverse events associated with Licensed Product.

     7.4) Recalls.

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ARTICLE 8

LICENSE FEES AND MILESTONES

     8.1) Upfront License Fees. In consideration of the rights granted under this Agreement, Pharmacia shall pay Nastech a non-refundable, non-creditable license fee of Three Million Dollars ($3,000,000) within ten (10) days after the Execution Date

     8.2) Equity Purchase. Simultaneously with the execution of this Agreement, the Parties are entering into (i) an investment agreement, pursuant to which, and subject to the terms and conditions contained therein, Pharmacia shall, within ten (10) days after the Execution Date, purchase two hundred fifty thousand shares of common stock of Nastech at Twenty Dollars ($20.00) per share, which represents a premium of 43.37% to the volume weighted average market price of Nastech common stock during the month of December 2001, and (ii) a registration rights agreement, pursuant to which, and subject to the terms and conditions contained therein, Nastech shall register the common stock purchased by Pharmacia with the US Securities and Exchange Commission, at Nastech’s expense. The parties shall enter into further agreements, and execute and deliver documents as may be necessary or desirable to effectuate the provisions in this Section.

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     8.3) Development Milestone Payments.

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     For clarity, each Milestone Event shall be payable only once during the Term. As used in this Section 8.3, “Initiation” means when the first patient has been enrolled in the trial.

     8.4) Sales Milestone Payments. As further consideration for the rights granted under this Agreement, Pharmacia shall pay Nastech each of the non-refundable, non-creditable amounts specified below within forty-five (45) days after the end of the calendar quarter in which any of the following worldwide thresholds are achieved, the achievement of each of which shall be a Milestone Event:

     For clarity, the payments set forth in this Section 8.4 are payable only once, but are cumulative (e.g., [*]).

ARTICLE 9

SALES-BASED COMPENSATION

     9.1) Royalties. Pharmacia shall pay to Nastech, as further consideration for the rights granted under this Agreement, royalties based on Net Sales of Collaboration Product in the Territory as follows:

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     9.2) Duration of Obligation to Pay Sales-Based Compensation.

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     9.3) Minimum Sales.

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     9.4) Royalty Reports; Payments. Royalties payable hereunder will be paid to Nastech not later than forty-five (45) calendar days following the end of each calendar quarter after the First Commercial Sale and each such payment shall be accompanied by a report in writing showing the period to which such payment applies, the amount billed to Third Parties for Collaboration Product during such calendar quarter, the deductions from the amount billed to arrive at Net Sales, the total Net Sales for the period, the royalties due on such Net Sales, and any credits taken by Pharmacia against such royalties pursuant to Sections 9.9 or 9.11 hereof. Each such report shall separately state the Net Sales of Pharmacia and each of its Sublicensees during the reporting period on a country-by-country basis, and shall include all such information as may reasonably be required to determine fully and accurately the royalties due Nastech for such period.

     9.5) Interest on Late Payments. If Pharmacia fails to pay in full on or before the date the amount is due any royalty, fee or other amount that Pharmacia is required to pay under this Agreement, Pharmacia shall pay to Nastech (or its designee), on demand, interest at a per annum rate equal to [*] to be assessed from the first day after payment of the amount in question first became due, and thereafter calculated and payable monthly on the last day of each month, not in advance.

     9.6) Taxes. Nastech shall be solely responsible for any and all taxes due or payable on any sums paid to Nastech under this Agreement. Pharmacia shall withhold, or cause to be withheld, and timely pay, or cause to be paid, over to the appropriate tax authorities all taxes (other than taxes imposed on or measured by net income) which Pharmacia is required to withhold under the applicable Law of any country for the account of Nastech. Insofar as practicable, Pharmacia shall advise Nastech in advance of such deduction or withholding and shall furnish Nastech with receipts and with other information reasonably requested by Nastech evidencing such deductions and withholding. Nastech shall have the right to contest any such withholding in its own name. Proof of payment of such taxes shall be provided to Nastech within thirty (30) days after payment. Pharmacia will reasonably cooperate with Nastech to obtain the benefit of any applicable tax Law or treaty, including the pursuit of any refund or credit of such tax to Nastech.

     9.7) Records; Audits. Pharmacia and its Affiliates shall keep and maintain complete and accurate records and books of account documenting all revenues, expenses and all other data necessary for the calculation of royalties. Pharmacia and its Affiliates shall permit nationally recognized independent accountants retained by Nastech, to whom Pharmacia shall have no reasonable objection, upon reasonable prior written notice, to have access to its and its Affiliates’ records and books and premises for the sole purpose of determining the appropriateness of calculation of royalties due under this Agreement for any calendar year ending no more than three (3) years prior to the date of such request. Such examination shall be conducted during regular business hours and no more than once in each calendar year during the term of this Agreement and once during the calendar year following the expiration or termination of this Agreement.

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     Such audit shall be at Nastech’s cost and expense; provided that, in the event any such audit reveals that Pharmacia has underpaid Nastech by an amount greater than five percent (5%) of the amounts due to Nastech in the period being audited, Pharmacia shall also reimburse Nastech for the reasonable out-of-pocket cost and expense of conducting the audit. If any audit reveals an overpayment by Pharmacia, Nastech shall (i) credit the amount of such overpayment to Pharmacia against the payment of royalties due for the next calendar quarter, with any amount of such overpayment in excess of such royalties carried over as a credit against the payment of royalties due for the succeeding calendar quarter until full credit of such overpayment is given; or (ii) in the event that such overpayment is discovered after termination or expiration of the Term, Nastech shall promptly refund such overpayment to Pharmacia.

     9.8) Currency of Payment. All references to “Dollars” or “$” herein are to United States Dollars. All payments to be made by Pharmacia to Nastech hereunder shall be made in United States Dollars. Where Collaboration Product are sold in a currency other than United States Dollars, conversion of sales recorded in local currencies to United States Dollars will be performed in a manner consistent with Pharmacia’s normal practices used to prepare its audited financial statements for internal and external reporting purposes.

     9.9) Third Party Licenses. In the event one or more patent licenses from Third Parties are required by Pharmacia or its Sublicensees in order to Develop, make, have made, use or sell a Collaboration Product in a country (“Third Party Patent Licenses”), [*] of any consideration actually paid under such Third Party Patent Licenses by Pharmacia or its Sublicensees shall be fully creditable against royalties payable to Nastech with respect to sale of such Collaboration Product; provided, however, in no event shall such credit cause the royalties paid to Nastech for any particular calendar quarter to be reduced to less than fifty percent (50%) of the amount that would otherwise be payable to Nastech for such calendar quarter pursuant to the provisions of Section 9.1 hereof; provided, further that any unused credits shall be carried over to future calendar quarters throughout the Term. Upon the expiration or termination of this Agreement, Nastech shall have no obligation to make any payment in respect of any balance that might otherwise be due with respect to its share of the consideration paid by Pharmacia or its Sublicensees under the Third Party Patent Licenses and which remains after the foregoing credits against royalties have been taken by Pharmacia.

     9.10) Compulsory License. Pharmacia and Nastech shall use Commercially Reasonable and Diligent Efforts to prevent or avoid any Third Party from obtaining or being granted a Compulsory License, and to the extent that a Third Party does obtain or is granted a Compulsory License, Pharmacia and Nastech will use Commercially Reasonable and Diligent

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Efforts to limit or reduce the scope or applicability of such Compulsory License. If, notwithstanding Pharmacia’s and Nastech’s use of Commercially Reasonable and Diligent Efforts, any Third Party obtains a Compulsory License in any country, then Nastech or Pharmacia (whoever has first notice) shall promptly notify the other Party. If the royalty rate payable by the grantee of the Compulsory License is less than the above royalty rates, the above royalty rates shall be reduced to such lower rate enjoyed by such Third Party grantee in the subject country, for so long as sales are made pursuant to the Compulsory License.

     9.11) Royalty Credit for Sample Costs. [*] of all payments made by Pharmacia to Nastech under the Supply Agreement with respect to the purchase of samples of Collaboration Product for promotional purposes shall be fully creditable against royalties payable to Nastech with respect to sale of such Collaboration Product; provided, however, in no event shall such credit cause the royalties paid to Nastech for any particular calendar quarter to be reduced to less than [*] of the amount that would otherwise be payable to Nastech for such calendar quarter pursuant to the provisions of Section 9.1; provided, further that any unused credits shall be carried over to future calendar quarters throughout the Term until realized in full by Pharmacia. Upon the expiration or termination of this Agreement for any reason, Nastech shall promptly pay to Pharmacia the balance of any credit due Pharmacia pursuant to this Section 9.11 which has not yet been taken by Pharmacia.

ARTICLE 10

INTELLECTUAL PROPERTY RIGHTS

     10.1) Disclosure of Program Inventions. Each Party shall promptly disclose to the other Party the conception or reduction to practice of Program Inventions by employees or others acting on behalf of such Party. All disclosures under this Section 10.1 shall be made at least sixty (60) days prior to any public disclosure of such Program Invention or any required submission to government agencies in compliance with the requirements of government supported research.

     10.2) Ownership of Program Inventions. All right, title and interest in all Program Inventions shall be owned as follows:

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     10.3) Ownership of Trademarks. Pharmacia shall select and own all trademarks and service marks associated with Collaboration Product in the Territory (collectively, “Product Marks”). Pharmacia shall also own any domain names associated with Collaboration Product in the Territory, including any domain names which contain Product Marks. Nastech hereby agrees that at no time during the Term will it or any of its Affiliates attempt to use or register any trademarks, marks or trade names confusingly similar to such Product Marks or take any other action with a view to damaging the rights or goodwill in any of the Product Marks in any country.

     10.4) Assignment of Program Inventions. Each Party agrees that all employees acting on its behalf in performing its obligations under this Agreement shall be obligated to assign to such Party, or as such Party shall direct, all Program Inventions conceived or reduced to practice by such employee as part of the activities conducted under this Agreement. In the case of non-employees working on behalf of a Party, that Party shall endeavor to obtain either an assignment or license establishing its Control of all Program Inventions conceived or reduced to practice by such non-employees.

     10.5) Prosecution Patent Rights.

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     10.6) Prosecution Costs. Pharmacia shall be responsible for any out-of-pocket costs or expenses reasonably incurred by Nastech and approved by Pharmacia (such approval not to be unreasonably withheld or delayed), after the Effective Date of this Agreement, in the course of filing, prosecuting and maintaining any Nastech Owned Patents related to the Collaboration Product (excluding any Joint Patents) up to a total cost of [*]. So long as Pharmacia is required to pay for the filing, prosecuting and maintaining Nastech Owned Patents under this Section, Pharmacia shall have full rights of consultation with Nastech and patent counsel selected by Nastech, that Pharmacia has no reasonable objections to, in all matters related to Nastech Owned

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Patents. Nastech shall use reasonable diligent efforts to implement all reasonable requests made by Pharmacia with regard to preparation, filing, prosecution and/or maintenance of the patent applications and patents related to Nastech Owned Patents. Nastech shall be responsible for any costs or expenses incurred by it in the course of filing, prosecuting and maintaining the Nastech Owned Patents (excluding any Joint Patents) in excess of [*]. Pharmacia shall be responsible for any costs or expenses incurred by it in the course of filing, prosecuting and maintaining the Pharmacia Patents (excluding any Joint Patents). The Development Oversight Committee shall determine which of the Parties shall be responsible for the reasonable out of pocket costs and expenses incurred by the Parties in filing, prosecuting and maintaining any Joint Patents; provided, however, that in the event the Development Oversight Committee is unable to agree upon an appropriate allocation between the Parties, the Parties shall share such costs and expenses equally on an ongoing basis.

     10.7) Cooperation. Each of Nastech and Pharmacia shall make available to the other Party (or to the other Party’s authorized attorneys, agents or representatives) its employees, agents or consultants to the extent necessary or reasonable to enable the appropriate Party to file, prosecute and maintain patent applications and resulting patents with respect to inventions owned by a Party and relating to Collaboration Product for use in the Field, and for periods of time sufficient for such Party to obtain the necessary assistance from such personnel. Where appropriate, each of the Party shall sign or cause to have signed all documents necessary for the same.

     10.8) Notice of Issuance. Nastech shall keep Pharmacia informed with regard to the status of the Nastech Owned Patents and the Joint Patents for which it is the Prosecuting Party, and Pharmacia shall keep Nastech informed with regard to the status of Pharmacia Patents and any Joint Patents for which it is the Prosecuting Party. Nastech shall promptly deliver or have delivered to Pharmacia copies of all patent applications, amendments, related correspondence, and documents concerning the Nastech Owned Patents and Joint Patents for which it is the Prosecuting Party, and Pharmacia shall promptly deliver or have delivered to Nastech copies of all patent applications, amendments, related correspondence, and documents concerning the Pharmacia Patents and any Joint Patents for which it is the Prosecuting Party. Each Party shall notify the other Party of the issuance of each patent included within the Patent Rights for which the notifying Party is responsible pursuant to Section 10.5 above, giving the date of issue and patent number for each such patent.

     10.9) No Implied Rights. Except as otherwise expressly provided in this Agreement, under no circumstances shall a Party, as a result of this Agreement, obtain any ownership interest or other right, title or interest in or to the Patent Rights or other intellectual property or Confidential Information of the other Party, including items Controlled or developed by the other Party, or delivered by the other Party to said Party, at any time pursuant to this Agreement.

     10.10) Assertion of Patent Infringement. Nastech and Pharmacia shall each promptly notify the other in writing of any alleged or threatened infringement of any patents which adversely affects the Development or Commercialization of Collaboration Product in the Field, or if either Party, or any of their respective Affiliates, shall be individually named as a defendant

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in a legal proceeding by a Third Party for infringement of a patent because of the manufacture, use or sale of a Collaboration Product in the Field or because of attempts to invalidate Pharmacia Patents or Nastech Owned Patents or Joint Patents in relation any Collaboration Product in the Field.

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     10.11) Third Party Infringement Suit. In the event that a Third Party sues Pharmacia or Nastech or their respective Affiliates alleging that the making, using, marketing, importing, exporting, selling or offering to sell Collaboration Product infringes or will infringe claims in said Third Party’s Patent Rights, then the Party so sued may elect to defend such suit, but shall fully consult with the other Party. Neither Party may settle any such action on terms that adversely affect the other Party without the express written consent of the other Party, such consent not to be unreasonably withheld or delayed. If, as a result of a judgment in the litigation or settlement with the Third Party, Pharmacia is required to pay royalties or other monies to such Third Parties, such payments may be treated as royalties under a Third Party Patent Licenses under Section 9.9.

     10.12) Cooperation. If either Party shall become engaged in or participate in any suit described in Section 10.10 or 10.11, or any investigation, claim, interference or other proceeding with any Third Party (including any proceeding before a relevant Regulatory Authority) relating in any way to the Collaboration Product or to any Pharmacia Technology, Nastech Technology, or Joint Technology affecting any of Collaboration Product, the other Party shall cooperate, and shall endeavor to cause its and its Affiliates and Sublicensees’ employees to cooperate, with such Party in all reasonable respects in connection therewith, including, without limitation, giving testimony and producing documents lawfully requested, and using its Commercially Reasonable and Diligent Efforts to make available to the other Party, at no cost to the other Party (other than reimbursement of actually incurred, reasonable out-of-pocket expenses), such employees who may be helpful, with respect to such suit, investigation, claim, interference or other proceeding.

     10.13) No Obligation to Prosecute. Notwithstanding any other provision of this Article, neither Party shall have an obligation to prosecute or maintain, or take or defend any action in respect of any Patent Right which is owned by a Third Party.

ARTICLE 11

CONFIDENTIALITY

     11.1) Confidential Information. Except as otherwise provided in this Article 11 and Section 12.7(b)(v), from the Execution Date until the fifth anniversary of the expiration of or termination of this Agreement, or for a period of ten (10) years from the Execution Date, whichever is the longer, the Parties shall, and shall procure that their Sublicensees and consultants, contractors and clinical investigators shall, maintain in confidence and use only for purposes specifically authorized under this Agreement any Confidential Information furnished to it by the other Party pursuant to this Agreement.

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     11.2) Disclosure. To the extent it is reasonably necessary or appropriate to fulfill its obligations or exercise its rights under this Agreement, a Party may disclose Confidential Information of the other Party it is otherwise obliged under this Article not to disclose:

     11.3) Exceptions. The obligation not to disclose Confidential Information shall not apply to any part of such Confidential Information that:

     In the case of a disclosure permitted by Section 11.3(e), the receiving Party shall, if practicable, notify the disclosing Party in writing prior to any such disclosure and use

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Commercially Reasonable and Diligent Efforts to secure confidential treatment thereof prior to its disclosure (whether by protective order or otherwise).

     11.4) Terms of Agreement. Notwithstanding the provisions of Sections 11.1 through 11.3, each Party shall be entitled to disclose the terms of this Agreement to its advisors and potential investors or other financing sources, without the consent of the other Party, on the condition that such entities or persons agree to keep such terms confidential for the same time periods and to the same extent as such Party is required to keep such terms confidential. Each party shall give the other Party a reasonable opportunity to review all filings with the United States Securities and Exchange Commission or any Stock Exchange describing the terms of this Agreement prior to submission of such filings, and shall give due consideration to any reasonable comments by the non-filing Party relating to such filing, including without limitation the provisions of this Agreement for which confidential treatment should be sought.

     11.5) Publications. Each Party recognizes the mutual interest in obtaining valid patent protection. Consequently, any Party or its Sublicensees, its employees or consultants wishing to make a publication (including any oral disclosure made without obligation of confidentiality) relating to work performed by or on behalf of such Party as part of the Global Development Plan or, in the case of Nastech’s activities relating to Collaboration Product, prior to the Execution Date (the “Publishing Party”) shall transmit to the other Party (the “Reviewing Party”) a copy of the proposed written publication at least sixty (60) days prior to submission for publication, or an abstract of such oral disclosure at least thirty (30) days prior to submission of the abstract or the oral disclosure, whichever is earlier. The Reviewing Party shall have the right to (a) request a delay in publication or presentation in order to protect patentable information, (b) propose modifications to the publication for patent reasons or (c) request that the information be maintained as a trade secret. With respect to publications or disclosures by investigators or other Third Parties, such publications and disclosures shall be subject to review by the Reviewing Party under this Section 11.5 only to the extent that the Publishing Party has the right to do so.

     11.6) Delay. If the Reviewing Party requests a delay as described in Section 11.5 above, the Publishing Party shall delay submission or presentation of the publication for a period of sixty (60) days from the date of such request to enable patent applications protecting each Party’s rights in such information to be filed. Upon the expiration of sixty (60) days, in the case of proposed written disclosures, or thirty (30) days, in the case of an abstract of proposed oral disclosures, from transmission of such proposed disclosures to the Reviewing Party, the Publishing Party shall be free to proceed with the written publication or the oral presentation, respectively, unless the Reviewing Party has requested the delay described above. To the extent practicable in the reasonable exercise of its discretion, the Publishing Party shall incorporate all modifications proposed under this Section. If a trade secret that is the subject of a request made under this Section cannot be otherwise protected without unreasonable expense to the Reviewing Party, such information shall be omitted from the publication.

     11.7) Press Releases. Following the Execution Date, the Parties shall issue one or more press releases regarding this Agreement, the Supply Agreement and the investment agreement and registration rights agreement contemplated by Section 8.2 (the Supply

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Agreement, investment agreement and registration rights agreement being referred to herein as the “Other Agreements”), the timing and content of which shall be mutually agreed. Except to the extent required by Law or the rules of a relevant Stock Exchange or as otherwise permitted in accordance with this Section 11.7, neither Party shall make any further public announcements concerning this Agreement, the Other Agreements or the subject matter hereof or thereof without the prior written consent of the other, which shall not be unreasonably withheld. Notwithstanding the foregoing, the Parties agree that each Party may desire or be required to issue press releases relating to the Agreement, the Other Agreements or activities hereunder or thereunder, and the Parties agree to consult with each reasonably and in good faith with respect to the text and timing of such press releases prior to the issuance thereof, provided that a Party may not unreasonably withhold consent to such releases, and that either Party may issue such press releases as it determines, based on advice of counsel, are reasonably necessary to comply with Law or for appropriate market disclosure. The principles to be observed by Pharmacia and Nastech in public disclosures with respect to this Agreement or the Other Agreements shall be: accuracy, compliance with applicable legal requirements, the requirements of confidentiality under Sections 11.1 through and including 11.5 and this Section 11.7 and normal business practice in the pharmaceutical and biotechnology industries for disclosures by companies comparable to Pharmacia and Nastech. In the event of a public announcement, the Party making such public announcement shall provide the other Party with a reasonable opportunity, judged in the light of the circumstances, and the right to approve the content of such announcement prior to its being made, which approval shall not be delayed or unreasonably withheld. The contents of any such announcement or similar publicity which has been reviewed and approved by the reviewing Party can be re-released by either Party without a requirement for re-approval.

     11.8) Termination of Prior Agreement. The Parties agree that as of the Effective Date the Confidentiality Agreement dated as of [*], between Pharmacia and Nastech is hereby terminated and superseded by the provisions of this Agreement, and any disclosures made under the terms of that Confidentiality Agreement shall be deemed to have been made under the terms of this Agreement.

ARTICLE 12

TERM AND TERMINATION

     12.1) Term. This Agreement becomes effective as of the Effective Date and shall terminate on a country-by-country basis on expiry of all of Pharmacia’s payment obligations in respect of sales of Collaboration Product in such country unless terminated earlier as set forth in this Article 12 (the “Term”).

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     12.2) Pharmacia’s Unilateral Termination Right. Pharmacia shall have the right to terminate this Agreement, at any time and for any reason, upon [*] days’ prior written notice to Nastech.

     12.3) Termination For Material Breach.

     12.4) Termination Upon Bankruptcy. This Agreement may be terminated by a Party upon written notice to the other in the event that (i) the other Party shall make an assignment for the benefit of its creditors, file a petition in bankruptcy, petition or apply to any tribunal for the appointment of custodian, receiver or any trustee for it or a substantial part of its assets, or shall commence any proceeding under any bankruptcy, reorganization, arrangement, readjustment of debt, dissolution or liquidation law or statute of any jurisdiction, whether now or hereafter in effect; or (ii) if there shall have been filed against the other Party any such bona fide petition or application, or any such proceeding shall have been commenced against it, in which an order for relief is entered or which remains undismissed for a period of [*]; or (iii) if the other Party by

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any act or omission shall indicate its consent to, approval of or acquiescence in any such petition, application or proceeding or order for relief or the appointment of a custodian, receiver or trustee for it or any substantial part of its assets, or shall suffer any such custodianship, receivership or trusteeship to continue undischarged for a period of [*]; or (iv) anything analogous to any of the foregoing occurs in any applicable jurisdiction. Termination shall be effective upon the date specified in such notice.

     12.5) Termination Relating to Competitive Product.

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     12.6) Rights of Pharmacia Upon Regularly Scheduled Termination. Upon the expiration of all of Pharmacia’s payment obligations under this Agreement with respect to a particular country, Pharmacia shall have a fully paid-up, non-exclusive license under the Nastech Technology to make, have made, sell, offer for sale, use and import Licensed Products in the Field in such country.

     12.7) Grant Backs to Nastech. In the event Pharmacia terminates this Agreement pursuant to Section 12.2 or Nastech terminates this Agreement pursuant to Section 12.3 or 12.4,

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then Pharmacia’s rights under the Licenses (and any ancillary rights derived therefrom) shall terminate and

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The Parties shall use Commercially Reasonable and Diligent Efforts to complete the transition of the Development and Commercialization of the Collaboration Product from Pharmacia to Nastech pursuant to this Section 12.7 as soon as is reasonably possible.

For the avoidance of doubt, Nastech shall not be required to provide Pharmacia any consideration in exchange for the licenses or other rights to be granted to it pursuant to this Section 12.7; provided, however, (i) Nastech shall be solely responsible for paying any royalties, fees or other consideration that Pharmacia may be obligated to pay to a Third Party in respect of any such transfer or sublicense to Nastech of such licenses or other rights, (ii) for the avoidance of doubt, nothing in this paragraph shall limit Nastech’s obligation to reimburse Pharmacia for any costs reasonably incurred in performing any of its obligations pursuant to Section 12.7(b), and (iii) Nastech shall be responsible for paying Pharmacia certain royalties based on its sales of Collaboration Product in accordance with and subject to the provisions of Section 12.9(b).

     12.8) Other Residual Rights. Upon termination of this Agreement, except as specifically provided herein to the contrary, all rights and obligations of the Parties under this Agreement shall cease, except as otherwise provided in this Article 12 and as follows:

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     12.9) Certain Consequences of Termination.

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     12.10) Disposal of Inventory. Upon termination of this Agreement for any reason Pharmacia shall be free to sell its remaining and then existing inventory of Collaboration Product, together with any additional quantities of Collaboration Product which Pharmacia is obligated to purchase from Nastech under the Supply Agreement; provided, however, that Pharmacia shall be obligated to pay Nastech the royalties applicable to said subsequent sales in accordance with the terms and conditions set forth in this Agreement.

     12.11) Preservation of Rights upon Termination. The rights set out in this Article 12 are without prejudice to any other rights a Party may have in respect of any such termination.

ARTICLE 13

DISPUTE RESOLUTION

     13.1) Non-Binding Mediation. In the event of any controversy or claim arising out of relating to or in connection with any provision of this Agreement, or the rights or obligations of the Parties hereunder (other than those to be resolved pursuant to Sections 3.3(b) and 5.5), the Parties shall try to settle their differences amicably between themselves. Either Party may initiate such informal dispute resolution by sending written notice of the dispute to the other Party, and within ten (10) Business Days after such notice appropriate representatives of the Parties shall meet for attempted resolution by good faith negotiations. If such representatives are unable to resolve promptly such disputed matter within the said ten (10) Business Days, either Party may refer the matter by written notice to the other to the President, Global Prescription Business of Pharmacia or his designee and the Chief Executive Officer of Nastech or his designee for discussion and resolution. If such individuals or their designees are unable to resolve such dispute within thirty (30) days of such written notice, the Parties shall refer the dispute to mediation in New York, New York before resorting to litigation. Such mediation shall be conducted pursuant to the commercial mediation rules of the American Arbitration Association. If any unresolved matter is not resolved within 30 days following referral to non-binding mediation pursuant to this Section 13.1, either Party may, subject to Sections 17.5 and 17.13, seek any remedy, at law or in equity that may be available.

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ARTICLE 14

REPRESENTATIONS, WARRANTIES AND COVENANTS

     14.1) Representation of Authority; Consents. Nastech and Pharmacia each represent and warrant to the other Party that as of the Execution Date (a) it has full right, power and authority to enter into this Agreement, (b) this Agreement has been duly executed by such Party, (c) so far as it is aware (not having taken legal advice in jurisdictions other than the USA) (i) this Agreement constitutes a legal, valid and binding obligation of such Party, enforceable in accordance with its terms, subject to all limitations of bankruptcy, liquidation, reorganization, insolvency, moratorium and enforcement of creditors’ rights generally, general principles of equity (including without limitation those relating to specific performance, injunctions and other remedies) and public policy constraints (including those pertaining to limitations and/or exclusions of liability, competition law, penalties and jurisdictional issues including conflicts of laws), and (ii) all necessary consents, approvals and authorizations of all government authorities and other persons and entities required to be obtained by such Party in connection with the execution, delivery and performance of this Agreement have been and shall be obtained.

     14.2) No Conflict. Each Party represents to the other Party that as of the Execution Date notwithstanding anything to the contrary in this Agreement, the execution and delivery of this Agreement and the performance of such Party’s obligations hereunder (a) do not conflict with or violate such Party’s corporate charter and bylaws or any requirement of applicable laws or regulations and (b) do not and shall not conflict with, violate or breach or constitute a default or require any consent under, any contractual obligation of such Party.

     14.3) Knowledge of Pending or Threatened Litigation. Each Party represents and warrants to the other Party that as of the Execution Date there is no claim, investigation, suit, action or proceeding pending against it and of which it has received written notice or, to the knowledge of such Party, threatened against it before or by any governmental entity or arbitrator that, individually or in the aggregate, could reasonably be expected to materially impair the ability of such Party to perform any obligation under this Agreement; provided that the foregoing representation and warranty does not apply to interference proceedings before the United States Patent and Trademark Office, opposition proceedings before the European Patent Office or any similar or analogous proceeding before any similar competent authority responsible for issuing patents (and including appeals from the same).

     14.4) Additional Representations and Warranties of Nastech. Nastech further represents and warrants to Pharmacia, as of the Execution Date, as follows:

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     14.5) Additional Warranty by Pharmacia. Pharmacia represents and warrants to Nastech, as of the Execution Date, that:

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     14.6) Disclaimer of Warranty. Except as expressly set forth in this Article 14, neither Party has made, and nothing in this Agreement shall be construed as, a warranty or representation (i) that any Collaboration Product made, used, sold or otherwise disposed of under the Licenses is or will be free from infringement of patents, copyrights, trade-marks, industrial design or other intellectual property rights of any Third Party or (ii) regarding the effectiveness, value, prospects for success (whether financial, regulatory or otherwise), safety, non toxicity, patentability, or non-infringement of any patent technology, Licensed Product, Collaboration Product or any information or results provided by either Party pursuant to this Agreement. Each Party explicitly accepts all of the same as experimental and for development purposes, and without any express or implied warranty from the other Party. EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT OR IN THE OTHER AGREEMENTS (as such term is defined in Section 11.7 hereof), EACH PARTY EXPRESSLY DISCLAIMS, WAIVES, RELEASES, AND RENOUNCES ANY REPRESENTATION OR WARRANTY OF ANY KIND, EXPRESS OR IMPLIED EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, WHETHER WRITTEN OR ORAL, OR ARISING FROM COURSE OF PERFORMANCE, COURSE OF DEALING OR USAGE OF TRADE, INCLUDING, WITHOUT LIMITATION, ANY REPRESENTATION OR WARRANTY WITH RESPECT TO NONINFRINGEMENT, VALUE, ADEQUACY, FREEDOM FROM FAULT, QUALITY, EFFICIENCY, SUITABILITY, CHARACTERISTICS OR USEFULNESS, OR MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

     14.7) Notwithstanding Sections 14.6 or 17.13, nothing in this Agreement limits or excludes any Party’s liability for fraud or for death or personal injury caused by that Party’s own negligence.

ARTICLE 15

INDEMNIFICATION

     15.1) Indemnification.

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     15.2)Indemnification Procedures.The Party seeking indemnification pursuant to this Article 15 (the “Indemnified Party”) shall inform the other Party promptly of any claim for which it intends to seek indemnification and, at the other Party’s request, cooperate fully with the other Party in defending such claim. The Indemnified Party, at its expense, shall have the right to participate in any related suit or proceeding, subject to the ultimate control of the other Party (“Indemnifying Party”). The Indemnifying Party shall have full control over the suit or proceedings, including the right to settle, through counsel of its choice who is reasonably acceptable to the Indemnified Party; provided, however, the Indemnifying Party will not, absent the consent of the Indemnified Party (which consent will not be unreasonably withheld), consent to the entry of any judgment or enter into any settlement that (1) provides for any relief other than the payment of monetary damages for which the Indemnifying Party shall be solely liable and (2) where the claimant or plaintiff does not release the Indemnified Party from all liability in respect thereof. In no event shall a Party be liable pursuant to this Article 15 for any claims that are compromised or settled without its prior written consent.

ARTICLE 16

CONDITIONS

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ARTICLE 17

MISCELLANEOUS

     17.1) Entire Agreement; Amendments. This Agreement, the Other Agreements, and the Exhibits and Schedules referred to each such agreement, constitute the entire agreement between the Parties with respect to the subject matter hereof, and supersede all previous understandings, arrangements and agreements with respect to the subject matter hereof, whether written or oral. The Parties acknowledge that the Exhibits and Schedules referred to in this Agreement and the Other Agreements are being simultaneously delivered by the Parties on or before the Execution Date and are incorporated herein by reference. Any amendment or modification to this Agreement shall be made in writing signed by both Parties.

     17.2) Notices. Any consent or notice required or permitted to be given or made under this Agreement by one of the Parties to the other shall be in writing, delivered personally or by facsimile (and promptly confirmed by personal delivery or courier), by a next Business Day delivery service of a nationally recognized overnight courier service or by courier, postage prepaid (where applicable), addressed to such other Party at its address or facsimile number indicated below, or to such other address or facsimile number as the addressee shall have last furnished in writing to the addressor in accordance with this Section 17.2 and shall be effective upon receipt by the addressee.

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     17.3) Force Majeure. Neither Party shall be held liable or responsible to the other Party nor be deemed to have defaulted under or breached this Agreement for failure or delay in fulfilling or performing any term of this Agreement to the extent such failure or delay is caused by or results from causes beyond the reasonable control of the affected Party, provided, however, that the Party so affected shall use Commercially Reasonable and Diligent efforts to avoid or remove or mitigate such causes of non-performance, and shall continue performance with reasonable dispatch whenever such causes are removed. Each Party shall provide the other Parties with prompt written notice of any delay or failure to perform that occurs by reason of force majeure. The Parties shall mutually seek a resolution of the delay or the failure to perform in good faith.

     17.4) Compliance with Export Regulations. Neither Party shall export any technology licensed to it by the other Party under this Agreement except in compliance with applicable export Laws.

     17.5) Choice of Law; Jurisdiction. This Agreement shall be governed and interpreted in all respects under the laws of the State of New York, without regard to principles of conflict of laws, except matters of intellectual property law, which shall be determined in accordance with the intellectual property laws relevant to the intellectual property in question. The provisions of the United Nations Convention on Contracts for the International Sale of Goods shall not apply to this Agreement or the Supply Agreement or any subject matter hereof or thereof. Except as expressly provided in this Section 17.5 with respect to interim equitable relief, and subject to the provisions of Article 13, any action or proceeding arising out of or relating to this Agreement, or any of the transactions contemplated hereby, shall be brought exclusively in the courts of the State of New York, or the United States District Court for the Southern District of New York, located in the Borough of Manhattan, City of New York, and the respective appellate courts with respect thereto, and the Parties hereby irrevocably consent to the personal jurisdiction and venue of the foregoing courts with respect to all such actions and proceedings and waive all defenses

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inconsistent with the terms of this Section 17.5. Each Party hereby further irrevocably waives, to the fullest extent permitted by applicable Law, all rights to trial by jury in any such action or proceeding, whether based upon contract, statute, tort or otherwise. The Parties hereby acknowledge that a breach of its obligations may cause irreparable harm and that damages as a remedy for any such breach may be inadequate. The Parties hereby agree that, in the event of any such breach, in addition to all other available remedies under this Agreement (which, except as and to the extent otherwise expressly herein provided shall be cumulative and not exclusive of any rights or other remedies in equity or in law), the non-breaching Party shall have the right to seek interim equitable relief in an appropriate forum to enforce such obligations.

     17.6) Assignment. This Agreement may not be assigned or otherwise transferred by any Party without the consent of the other Party, such consent not to be unreasonably withheld, conditioned or delayed; provided, however, that either Nastech or Pharmacia may, without such consent, assign its rights and obligations under this Agreement (a) to any Affiliate, provided such interest shall be retransferred to the relevant Party if such entity ceases to be an Affiliate of such Party, and provided further that the assigning Party shall guarantee the performance of such Affiliate, (b) in connection with a merger, consolidation or sale of substantially all of such Party’s assets to a Third Party of good financial standing; provided, however, that such Party’s rights and obligations under this Agreement shall be assumed by its successor in interest in any such transaction and shall not be transferred separate from all or substantially all of its other business assets, including without limitation those business assets that are the subject of this Agreement or (c) if a Party or its Affiliates divests a Collaboration Product in order to comply with the Law or the requirements of any governmental agency or authority as a result of merger or acquisition, provided,that (i) the assignee shall be of good financial standing, and (ii) [*]. In cases where Pharmacia is required to obtain Nastech’s consent to a proposed assignment or other transfer pursuant to the provisions of this Section 17.6, it shall not be unreasonable for Nastech to withhold such consent if the proposed Third Party assignee is engaged in the development, marketing, sales, or other commercialization of [*] in the Field. Any permitted successor, assignee or other transferee hereunder shall assume all rights and obligations of its predecessor, assignor or other transferor under this Agreement; accordingly, all references to the predecessor, assigning or transferring Party shall be deemed references to the successor, assignee or transferee to whom the Agreement is so transferred or assigned. Any purported assignment or other transfer not in compliance with this Section 17.6 will be null and void.

     17.7) Consequences of a Triggering Event.

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     17.8) Non-Solicitation. After the Execution Date and until the expiration or termination of this Agreement, neither Party or its Affiliates shall solicit any employee of the other Party or its Affiliates with whom it has come in contact or interacted for the purposes of the performance of this Agreement to leave the employment of the other Party and accept employment with the first Party.

     17.9) Joint Committees. Members of the Development Oversight Committee, the Commercialization Committee and any subcommittees thereof shall be, and shall remain, employees of Nastech or Pharmacia, as the case may be.

     17.10) No Strict Construction. This Agreement has been prepared jointly and shall not be strictly construed against either Party.

     17.11) Headings. The captions or headings of the sections or other subdivisions hereof are inserted only as a matter of convenience or for reference and shall have no effect on the meaning of the provisions hereof.

     17.12) Severability. If any provision hereof should be held invalid, illegal or unenforceable in any respect in any jurisdiction, the invalid, illegal or unenforceable of one or several provisions of this Agreement shall not affect the validity of this Agreement as a whole. The Parties shall make a good faith effort to replace the invalid or unenforceable provision with a valid one which in its economic effect is most consistent with the invalid or unenforceable one. If the invalid, illegal or unenforceable provisions are of such essential importance to this Agreement that it is to be reasonably assumed that the Parties would not have entered into this Agreement without the invalid, illegal or unenforceable provisions, the Parties shall negotiate in good faith an orderly termination of this Agreement consistent with the principles set out in Article 12.

     17.13) No Consequential Damages. UNLESS RESULTING FROM A PARTY’S WILLFUL MISCONDUCT, NEITHER PARTY HERETO WILL BE LIABLE FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THIS AGREEMENT OR THE EXERCISE OF ITS RIGHTS OR PERFORMANCE OF ITS OBLIGATIONS HEREUNDER, INCLUDING WITHOUT LIMITATION LOST PROFITS, ANTICIPATED PROFITS, LOST GOODWILL, LOST REVENUE, LOST PRODUCTION, LOST CONTRACTS AND LOST OPPORTUNITY, ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF SUCH DAMAGES. NOTHING IN THIS SECTION 17.13 IS INTENDED TO LIMIT OR RESTRICT ANY PAYMENT OBLIGATION OR THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF EITHER PARTY.

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     17.14) General Provisions.

     [17.15) Employees and Agents. Each Party shall be responsible for all acts, errors and omissions of its Affiliates, and in the case of Pharmacia its Sublicensees, as well as such Party’s and its Affiliates’ employees acting within the scope of their employment, in each case which relate to this Agreement and which would constitute a breach of this Agreement if done directly by such Party..

     17.16) Patent Markings on Collaboration Product. All Units of Collaboration Product offered for sale by Pharmacia or any of its Sublicensees, and all packaging materials

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used in connection therewith, shall feature a clear and conspicuous display of all patent and other restrictive and proprietary notices and legends applicable to the Nastech Technology in conformity with customary industry practice and applicable Law. All such notices shall include the number of any applicable Patents and identify Nastech (or where a Joint Patent, Nastech and Pharmacia) or its designee as the Patent owner.

     17.17) Whole Agreement. Each Party acknowledges that in entering into this Agreement it has not relied on any representation, warranty, collateral contract or other assurance (except those expressly set out in this Agreement or the Other Agreements together with the Exhibits and Schedules) made by or on behalf of any other Party before the signature of this Agreement. Each Party waives all rights and remedies which, but for this Section, might otherwise be available to it in respect of any such representation, warranty, collateral contract or other assurance..

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IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first set forth above.

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SCHEDULE A

NASTECH OWNED PATENTS

     Intranasally Delivered Apomorphine Technology & Patents and/or Applications Technology

Patent Portfolio of Nastech

SCHEDULE B

TARGET PRODUCT PROFILE

[*]

SCHEDULE 2.4

[*]

SCHEDULE 4.3

[*]

SCHEDULE 4.5

ONGOING PRE-CLINICAL AND CLINICAL STUDIES]

[*]

SCHEDULE 9.1

EXAMPLE OF ROYALTY CALCULATION

[*]

SCHEDULE 12.5

Assumptions: