Employment Offer by and between Adamas Pharmaceuticals, Inc. and Neil F. McFarlane, dated September 12, 2019

We are very excited to have you join Adamas Pharmaceuticals, Inc. (the “Company”). In this letter, I would like to set forth the terms and conditions of your employment relationship with the Company.

Title and Responsibilities. I am pleased to offer you the full-time position of Chief Executive Officer working at our offices in Emeryville, CA. Your position with the Company is pursuant to the terms and conditions of this letter and accompanying Confidential Information and Invention Assignment Agreement, and will commence on September 16, 2019. You will report to the Board of Directors and your duties and responsibilities include, but are not limited to, leading Adamas’ commercial and development strategy, building a strong team, leading the Executive Leadership Team, and raising the Company’s profile with external constituencies.

Compensation. You will initially receive an annual base salary of $625,000. Your salary will be paid periodically in accordance with normal Company payroll practices and are subject to the usual required deductions and tax withholdings. In addition to your salary, you will be eligible to participate in the Company’s Bonus Plan. The annual target bonus for your position is sixty percent (60%) of your annual base salary, and any award would be based upon both the Company’s achievement of its performance goals and your achievement of your personal goals to be set with the Board of Directors. The performance targets for the corporation will be determined in conjunction with the Board of Directors and the Compensation Committee. The actual award, if any, will be prorated from your date of hire for your first year of employment and will be subject to the usual required deductions and tax withholdings. The Company may change your compensation and benefits from time to time in its sole discretion.

Equity Awards.  In addition, subject to the approval of the Company’s Board of Directors or its Compensation Committee, it will be recommended that as a material inducement to you to accept this offer and to enter into employment with the Company, it will be recommended that you be granted two equity awards, each of which will be granted under, and be subject to the terms of, either the Company’s 2014 Equity Incentive Plan or the Company’s 2016 Inducement Plan (each, the “Plan”). The initial equity award will be: (1) a stock option to purchase 250,000 shares of the Company’s common stock (the “Option”) and (2) an award of 125,000 Restricted Stock Units (the “RSU Award”). The exercise price per share of the Option will equal the fair market value of a share of Common Stock on the date of grant, as determined by the Board of Directors or Compensation Committee.  If approved, and provided that you remain in Continuous Service (as defined in the Plan) to the Company on each date, 25% of the Option shares shall vest and become exercisable on the one year anniversary of your employment commencement date and an additional 1/48th of the Option shares shall vest and become exercisable on a monthly basis thereafter over the following 36 months, as described in the applicable Plan and your Option grant documents. If approved, and provided that you remain in Continuous Service to the Company on each date, 25% of the shares under the RSU Award will vest annually, as described in the applicable Plan and your RSU Award grant documents. The second equity

award will be considered in the first calendar quarter of 2020 as part of the annual review of executive compensation programs. The Board of Directors will determine the appropriate award at that time, but in any case, the award will be not less than: 1) a stock option to purchase 100,000 shares of the Company’s common stock; and 2) an award of 50,000 Restricted Stock Units. The exercise price per share of the Option will equal the fair market value of a share of Common Stock on the date of grant, as determined by the Board of Directors or Compensation Committee. Vesting of this second equity award will be the same as described above for the first equity award.

Travel and Lodging Allowance. Your relocation to the San Francisco Bay Area is not expected to be completed until March 16, 2021; however, during the period between your hire date and March 16, 2021 you will be expected to spend the majority of your working time in the San Francisco Bay Area. The Company will reimburse you for all reasonable commuting expenses you incur to commute to Emeryville, CA prior to your relocation (including airfare and lodging)(the “Commute Expenses”). If you incur any tax liability as a result of the reimbursement of the Commute Expenses, the Company will make an additional payment to you (the “Commute Expenses Gross-Up Payment”) sufficient to cover the tax liability incurred by you as a result of the reimbursement of the Commute Expenses; provided, however, that the Commute Expenses Gross-Up Payment shall not exceed seventy five percent (75%) of the amount of the aggregate Commute Expenses. The Commute Expenses Gross-Up Payment shall be paid to you shortly after December 31 of the year in which the expenses were incurred, but in no event later than March 15 of the following year.

Relocation Advance. To assist you with your move to the Bay Area, the Company will provide you with a relocation advance in the amount of $350,000, less customary deductions and withholdings (the “Relocation Advance”). This Relocation Advance shall be treated and reported as taxable income to you. The Relocation Advance will be paid to you in two installments. The Company will make the first installment payment in the amount of $150,000 in January, 2020 (the “First Installment”) and you will earn the First Installment once you have fully relocated to the San Francisco Bay Area within two years of your employment start date. Accordingly, you acknowledge and agree that if you have not fully relocated to the Bay Area prior to your two-year anniversary, then you are obligated to return the First Installment to the Company. The second installment payment in the amount of $200,000 will be paid at the time you have fully relocated your principal place of family residence to the San Francisco Bay Area, which is expected to occur within your first two years of employment (the “Second Installment”) and you will earn the Second Installment once you have remained employed by the Company for a total of two (2) years. Accordingly, you acknowledge and agree that if you resign from the Company for any reason or if the Company terminates your employment for Cause (as defined in the Plan), in either case within two (2) years of your employment start date, you will be obligated to return the Second Installment to the Company. You will be required to repay any portions of the Relocation Advance due under this section to the Company within thirty (30) days of your two (2) year anniversary or your employment separation date. 

Benefit Plans. During your employment with the Company, you will be eligible to participate in the employee benefit plans currently and hereafter maintained by the Company of general applicability to other employees of the Company. Details about these benefits are provided in the Employee Handbook and Summary Plan Descriptions, available for your review. Where a particular benefit is subject to a formal plan (for example, medical insurance or life insurance), eligibility to participate in and receive any particular benefit from the plan is governed solely by the applicable plan document. Additionally, the Company will pay the premiums for continuation of the UNUM Executive Supplemental Long Term Disability policy in which you are currently enrolled.

Paid Time Off. As part of these benefits, you will be entitled to paid time off (“PTO”) in accordance with the Company’s PTO policy as in effect from time to time. Currently, the Company offers full-time employees 21 days of PTO per calendar year.

Attorneys’ Fees. The Company will reimburse you for attorneys’ fees incurred for review and advice regarding this offer letter and the associated documents, up to a maximum of $7,500.

Executive Severance Plan. Given your position with the Company, you will initially be eligible to participate in the Executive Severance Plan (the “Severance Plan”) pursuant to the terms of that Severance Plan. A copy of this Severance Plan is enclosed with this letter. Notwithstanding anything in the Severance Plan to the contrary, if there is a voluntary termination by you for Good Reason (as defined in the Severance Plan), it shall constitute a “Qualifying Termination” under the Severance Plan, unless such voluntary termination meets the definition of a “CIC Termination” (as defined in the Severance Plan), in which case it shall constitute a CIC Termination.

Company Policies and Confidential Information. You will be expected to abide by all Company rules and policies, and acknowledge in writing that you have read and will comply with the Company’s Employee Handbook. The Company considers the protection of its confidential information, proprietary materials and goodwill to be extremely important. Consequently, as a condition of your employment with the Company, you also are required to sign and fully comply with the Confidential Information and Invention Assignment Agreement enclosed with this letter.

No Conflicting Agreements or Obligations. In your work for the Company, you will be expected not to use or disclose any confidential information, including trade secrets, of any former employer or other person to whom you have an obligation of confidentiality. Rather, you will be expected to use only that information which is generally known and used by persons with training and experience comparable to your own, which is common knowledge in the industry or otherwise legally in the public domain, or which is otherwise provided or developed by the Company. You agree that you will not bring onto Company premises, or upload onto any of the Company’s systems, any unpublished documents, property, or confidential information belonging to any former employer or other person to whom you have an obligation of confidentiality. You hereby represent that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company. You also represent that by performing your duties and responsibilities for Adamas, you will not breach any obligations you may owe to any of your former employers.

Conflicting Outside Employment. While employed by the Company, you may not work as an employee or consultant of any other organization or engage in any other activities which conflict or interfere with your employment obligations to the Company, including working for a competitive organization, or undertaking any activities that could create a conflict of interest.

At-Will Employment. Your employment with the Company is “at-will,” which means that either you or the Company may terminate your employment at any time, with or without cause, and with or without advance notice. No provision of this offer letter or the accompanying Confidential Information and Invention Assignment Agreement shall be construed to create an express or implied employment contract, or a promise of employment for any specific period of time.

Authorization to Work. This offer is conditioned upon the following: (1) your presenting sufficient evidence of your authorization to work in the United States and your identity sufficient to allow the Company

to complete the Form I-9 required by law; (2) satisfactory completion of a background and reference check; and (3) your signature on the Confidential Information and Invention Agreement. You agree to assist as needed and to complete any documentation at the Company’s request to meet these conditions.

Please contact me at (415) 706-3220 if you have any questions. I’m delighted to welcome you to the Company, and I look forward to your participation in the Company’s future success. Please sign below to indicate your acceptance and agreement to the terms set forth in this offer letter and return the signed offer letter to your Human Resources Representative.

This offer will expire at midnight on September 12, 2019, unless accepted by you in writing prior to such date.