CASTLE BIOSCIENCES INC Real Estate Contracts & Agreements

Fourth Amendment to Standard Office Lease, dated April 18, 2023, by and between the Registrant and Alturas Siete II, LLC (Filed With SEC on May 3, 2023)

Second Amendment to Commercial Lease, executed December 15, 2022, by and between the Registrant and Tannos Land Holdings III, LLC (Filed With SEC on February 28, 2023)

Third Amendment to Standard Office Lease, dated February 9, 2023, by and between the Registrant and Alturas Siete, II, LLC (Filed With SEC on February 28, 2023)

Fifth Amendment to Standard Office Lease, dated October 24, 2022, by and between the Registrant and Alturas Siete I, LLC (Filed With SEC on February 28, 2023)

Lease Agreement, dated April 1, 2022, by and between the Registrant and ACA Concourse East Unit 3 LLC (Filed With SEC on May 9, 2022)

Fourth Amendment to Standard Office Lease, dated March 11, 2022, by and between the Company and Alturas Siete (Filed With SEC on March 17, 2022)

Third Amendment to Standard Office Lease, dated November 29, 2021, by and between the Company and Alturas Siete, I, LLC (Filed With SEC on December 3, 2021)

Second Amendment to Standard Office Lease, dated November 29, 2021, by and between the Company and Alturas Siete, II, LLC (Filed With SEC on December 3, 2021)

First Amendment to Standard Office Lease, dated February 1 (Filed With SEC on May 10, 2021)

First Amendment to Commercial Lease, dated November 13, 2020, by and between the Registrant and Tannos Land Holdings III, LLC (Filed With SEC on March 11, 2021)

First Amendment to Lease, dated December 4, 2018, by and between the Registrant and Alturas Siete I, LLC (Filed With SEC on March 10, 2020)

Standard Office Lease, dated December 16, 2019, by and between the Company and Alturas Siete, II, LLC (Filed With SEC on December 19, 2019)

Second Amendment to Standard Office Lease, dated December 16, 2019, by and between the Company and Alturas Siete, I, LLC (Filed With SEC on December 19, 2019)

Commercial Lease, dated December 17, 2019, by and between the Company and Tannos Land Holding III, LLC (Filed With SEC on December 19, 2019)

Standard Office Lease, dated as of October 5, 2015, by and between the Registrant and Merced Restart Phoenix Investors II, LLC (Filed With SEC on June 26, 2019)

Office Building Lease, dated as of March 11, 2015, by and between the Registrant and RMG Leasing (a/k/a Cedarwood Professional Building), as amended (Filed With SEC on June 26, 2019)