Biotechnology Industry Participation Agreements

Amended Participation Agreement, dated April 2, 2024, by and between the Company and Frank Stokes (CASTLE BIOSCIENCES INC, Filed With SEC on May 2, 2024)

Amended Participation Agreement, dated April 2, 2024, by and between the Company and Derek Maetzold (CASTLE BIOSCIENCES INC, Filed With SEC on May 2, 2024)

Amended Participation Agreement, dated April 1, 2024, by and between the Company and Kristen Oelschlager (CASTLE BIOSCIENCES INC, Filed With SEC on May 2, 2024)

Amended Participation Agreement, dated April 1, 2024, by and between the Company and Tobin Juvenal (CASTLE BIOSCIENCES INC, Filed With SEC on May 2, 2024)

Amended and Restated Participation Agreement, by and between the Company and Kristin Yarema, Ph.D., dated January 1, 2024 (Poseida Therapeutics, Inc., Filed With SEC on January 4, 2024)

Third Amended and Restated Participation Agreement, dated as of March 27, 2023, by and among Old Saw Mill Holdings LLC, as lessee, Bank of America, N.A., as administrative agent,... (Regeneron Pharmaceuticals, Filed With SEC on March 29, 2023)

Second Amended and Restated Participation Agreement, dated as of March 2, 2022, by and among Old Saw Mill Holdings LLC, as lessee, Bank of America, N.A., as administrative agent,... (Regeneron Pharmaceuticals, Filed With SEC on March 8, 2022)

First Amendment to Amended and Restated Participation Agreement, dated as of October 6, 2021, by and among Old Saw Mill Holdings LLC, as lessee; the Registrant, as parent... (Regeneron Pharmaceuticals, Filed With SEC on February 7, 2022)

Amended and Restated Participation Agreement, by and between the Company and Eric Ostertag, M.D., Ph.D., dated February 1, 2022 (Poseida Therapeutics, Inc., Filed With SEC on February 1, 2022)

Amended and Restated Participation Agreement, by and between the Company and Mark Gergen, dated February 1, 2022 (Poseida Therapeutics, Inc., Filed With SEC on February 1, 2022)

Public Offering Participation Rights Agreement, dated March 2, 2021, by and between the Registrant and Zone III Healthcare Holdings, LLC (Caribou Biosciences, Inc., Filed With SEC on July 1, 2021)

Public Offering Participation Rights Agreement, dated March 2, 2021, by and between the Registrant and Ridgeback Capital Investments LP (Caribou Biosciences, Inc., Filed With SEC on July 1, 2021)

Public Offering Participation Rights Agreement, dated March 2, 2021, by and between the Registrant and PFM Health Sciences, LP (Caribou Biosciences, Inc., Filed With SEC on July 1, 2021)

Form of IPO Participation Right Letter (Elevation Oncology, Inc., Filed With SEC on June 4, 2021)

2010 Equity Participation Plan, as amended (BioRestorative Therapies, Inc., Filed With SEC on March 18, 2021)

2010 Equity Participation Plan, as amended (International Stem Cell CORP, Filed With SEC on August 12, 2020)

Participation Rights Letter Agreement, dated November 8, 2019, by and among RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd. and RTW Venture Fund Limited (Avidity Biosciences, Inc., Filed With SEC on May 22, 2020)

Amended and Restated Participation Agreement, dated as of May 2, 2019, by and among Old Saw Mill Holdings LLC, as lessee; Bank of America, N.A., as administrative agent; BA... (Regeneron Pharmaceuticals, Filed With SEC on May 3, 2019)

[FORM OF] PARTICIPATION RIGHTS AGREEMENT (Sun BioPharma, Inc., Filed With SEC on March 31, 2017)

BIORESTORATIVETHERAPIES, INC. 2010EQUITY PARTICIPATION PLAN (BioRestorative Therapies, Inc., Filed With SEC on March 22, 2017)

BIORESTORATIVE THERAPIES, INC. 2010 EQUITY PARTICIPATION PLAN (BioRestorative Therapies, Inc., Filed With SEC on September 25, 2015)

BIORESTORATIVE THERAPIES, INC. 2010 EQUITY PARTICIPATION PLAN (BioRestorative Therapies, Inc., Filed With SEC on March 31, 2015)

PARTICIPATION AGREEMENT Contract on the establishment of a silent partnership (PIERIS PHARMACEUTICALS, INC., Filed With SEC on December 18, 2014)

SECOND AMENDMENT TO PARTICIPATION AGREEMENT (CLEVELAND BIOLABS INC, Filed With SEC on August 11, 2014)

THIRD AMENDMENT TO PARTICIPATION AGREEMENT (CLEVELAND BIOLABS INC, Filed With SEC on August 6, 2014)

BIORESTORATIVE THERAPIES, INC. 2010 EQUITY PARTICIPATION PLAN (BioRestorative Therapies, Inc., Filed With SEC on April 11, 2014)

REVENUE PARTICIPATION AGREEMENT BY AND BETWEEN SUNESIS PHARMACEUTICALS,INC. AND RPI FINANCE TRUST DATED AS OF MARCH 29, 2012 (SUNESIS PHARMACEUTICALS INC, Filed With SEC on May 15, 2012)

FIRSTAMENDMENT TO PARTICIPATION AGREEMENT (CLEVELAND BIOLABS INC, Filed With SEC on August 16, 2010)

Participation Agreement dated October 31, 2008 with respect to the Pearce #1Well located Lee County, Texas (RenovaCare, Inc., Filed With SEC on March 11, 2009)

Participation Agreement dated September 9, 2008 with respect to the Haile #1Well located Frio County, Texas (RenovaCare, Inc., Filed With SEC on March 11, 2009)

Participation Agreement dated September 9, 2008 with respect to the Onnie Ray #1 Well located Lee County, Texas (RenovaCare, Inc., Filed With SEC on March 11, 2009)

Participation Agreement dated September 9, 2008 with respect to the Stahl #1Well located Fayette County, Texas (RenovaCare, Inc., Filed With SEC on March 11, 2009)

Participation Agreement dated September 9, 2008 with respect to the Haile #1Well located Frio County, Texas (RenovaCare, Inc., Filed With SEC on October 24, 2008)

Participation Agreement dated September 9, 2008 with respect to the Onnie Ray #1 Well located Lee County, Texas (RenovaCare, Inc., Filed With SEC on October 24, 2008)

Participation Agreement dated September 9, 2008 with respect to the Stahl #1Well located Fayette County, Texas (RenovaCare, Inc., Filed With SEC on October 24, 2008)

INTERNATIONAL STEM CELL CORPORATION 2006 EQUITY PARTICIPATION PLAN (International Stem Cell CORP, Filed With SEC on December 29, 2006)

NEOSTEM, INC. 2003 Equity Participation Plan 1 (CALADRIUS BIOSCIENCES, INC., Filed With SEC on November 3, 2006)

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Participation Agreements in the Biotechnology Industry