Express Scripts Holding Co. Indenture Agreements

Ninth Supplemental Indenture, dated as of December 20, 2018, by and among Cigna Corporation (formerly known as Halfmoon Parent, Inc.), Express Scripts, Inc. and MUFG Union Bank,... (Filed With SEC on December 20, 2018)

Twenty-Fifth Supplemental Indenture, dated as of December 20, 2018, by and among Cigna Corporation (formerly known as Halfmoon Parent, Inc.), Express Scripts Holding Company and... (Filed With SEC on December 20, 2018)

Second Supplemental Indenture dated as of December 20, 2018, by and among Express Scripts Holding Company, Cigna Holding Company (formerly known as Cigna Corporation) and U.S.... (Filed With SEC on December 20, 2018)

Twenty-Fourth Supplemental Indenture, dated as of November 30, 2017, among the Company, the Subsidiary Guarantors and Wells Fargo Bank, National Association, as Trustee (Filed With SEC on November 30, 2017)

Twenty-Third Supplemental Indenture, dated as of November 30, 2017, among the Company, the Subsidiary Guarantors and Wells Fargo Bank, National Association, as Trustee and... (Filed With SEC on November 30, 2017)

Twenty-Second Supplemental Indenture, dated as of November 30, 2017, among the Company, the Subsidiary Guarantors and Wells Fargo Bank, National Association, as Trustee (Filed With SEC on November 30, 2017)

TWENTIETH SUPPLEMENTAL INDENTURE Dated as of July 5, 2016 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS... (Filed With SEC on July 5, 2016)

NINETEENTH SUPPLEMENTAL INDENTURE Dated as of July 5, 2016 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS... (Filed With SEC on July 5, 2016)

EIGHTEENTH SUPPLEMENTAL INDENTURE Dated as of July 5, 2016 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS... (Filed With SEC on July 5, 2016)

SEVENTEENTH SUPPLEMENTAL INDENTURE Dated as of February 25, 2016 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE... (Filed With SEC on February 25, 2016)

SIXTEENTH SUPPLEMENTAL INDENTURE Dated as of February 25, 2016 Supplementing that Certain INDENTURE Dated as of November21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE... (Filed With SEC on February 25, 2016)

FIFTEENTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 16, 2016)

TWELFTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 16, 2016)

FIFTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 16, 2016)

FOURTEENTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 23, 2015)

ELEVENTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 23, 2015)

FOURTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 23, 2015)

THIRTEENTH SUPPLEMENTAL INDENTURE Dated as of June 5, 2014 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS... (Filed With SEC on June 5, 2014)

TWELFTH SUPPLEMENTAL INDENTURE Dated as of June 5, 2014 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS PARTY... (Filed With SEC on June 5, 2014)

ELEVENTH SUPPLEMENTAL INDENTURE Dated as of June 5, 2014 Supplementing that Certain INDENTURE Dated as ofNovember 21, 2011 Among EXPRESS SCRIPTS HOLDINGCOMPANY THE GUARANTORS... (Filed With SEC on June 5, 2014)

TENTH SUPPLEMENTAL INDENTURE (Filed With SEC on February 20, 2014)

THIRD SUPPLEMENTAL INDENTURE (Filed With SEC on February 20, 2014)

SECOND SUPPLEMENTAL INDENTURE (Filed With SEC on June 4, 2012)

NINTH SUPPLEMENTAL INDENTURE (Filed With SEC on June 4, 2012)

SECOND SUPPLEMENTAL INDENTURE (Filed With SEC on April 6, 2012)

FIRST SUPPLEMENTAL INDENTURE (Filed With SEC on April 6, 2012)

EIGHTH SUPPLEMENTAL INDENTURE (Filed With SEC on April 6, 2012)

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Express Scripts Holding Co. Indenture Agreements